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Pediatric Radiology
Published in: Pediatric Radiology 8/2006

01-08-2006 | Original Article

Correlation of grading and duration of periventricular echodensities with neurodevelopmental outcome in preterm infants

Authors: Bernhard Resch, Andrea Jammernegg, Eva Perl, Michael Riccabona, Ute Maurer, Wilhelm D. Müller

Published in: Pediatric Radiology | Issue 8/2006

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Abstract

Background

Transient periventricular echodensities (PVE) in preterm infants affect neurodevelopmental outcome.

Objective

To correlate the duration and grading of PVE with neurodevelopmental outcome.

Materials and methods

A retrospective, single-centre cohort study of infants with PVE diagnosed by ultrasonography from 1995 to 2000 with blinded grading and recognition of duration of PVE.

Results

A total of 72 infants (median gestational age 32 weeks, median birth weight 1,668 g) were diagnosed as having PVE. Minor neurological abnormalities were diagnosed in seven (10%), cerebral palsy in six (8%), developmental delay in seven (10%), and mild mental retardation in two (3%) of the infants. Differences regarding adverse outcome were not significant between infants with severity grade 1 compared to severity grade 2 (16% and 22%, respectively). There was a significant increase in adverse neurodevelopmental outcome with increasing duration of PVE. Of 33 infants with duration of PVE <7 days, 1 (3%) had an adverse neurodevelopmental outcome, compared to 6 (24%) of 25 infants with a duration of PVE of 7–14 days, and 6 (43%) of 14 infants with a duration of PVE >14 days (P<0.002, RR 7.920, 95% CI 1.017–61.661; P<0.001, RR 14.143, 95% CI 1.871–106.895, respectively).

Conclusion

The duration, but not the grading, of transient PVE was significantly correlated with neurodevelopmental outcome.
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Metadata
Title
Correlation of grading and duration of periventricular echodensities with neurodevelopmental outcome in preterm infants
Authors
Bernhard Resch
Andrea Jammernegg
Eva Perl
Michael Riccabona
Ute Maurer
Wilhelm D. Müller
Publication date
01-08-2006
Publisher
Springer-Verlag
Published in
Pediatric Radiology / Issue 8/2006
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-006-0178-2

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