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Journal of Hepato-Biliary-Pancreatic Sciences

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01-02-2013 | Original article

Correlation of apparent diffusion coefficient measured by diffusion-weighted MRI and clinicopathologic features in pancreatic cancer patients

Authors: Koichi Hayano, Fumihiko Miura, Hodaka Amano, Naoyuki Toyota, Keita Wada, Kenichiro Kato, Keiji Sano, Koji Takeshita, Tomoyoshi Aoyagi, Kiyohiko Shuto, Hisahiro Matsubara, Takehide Asano, Tadahiro Takada

Published in: Journal of Hepato-Biliary-Pancreatic Sciences | Issue 2/2013

Abstract

Background/purpose

The aim of this study was to evaluate the clinical usefulness of diffusion-weighted magnetic resonance imaging (DWI) in patients with pancreatic cancer by comparing the apparent diffusion coefficient (ADC) value with clinicopathologic features.

Methods

Twenty-two consecutive patients (12 men, 10 women; mean age 64.4 years) with pancreatic cancer underwent DWI before surgery. We retrospectively investigated the correlations between tumor ADC value and clinicopathologic features.

Results

Apparent diffusion coefficient value was significantly lower for pancreatic cancer than for noncancerous tissue (P < 0.001). Receiver operating characteristic analysis yielded an optimal ADC cutoff value of 1.21 × 10⁻³ mm²/s to distinguish pancreatic cancer from noncancerous tissue. There was a significant negative correlation between ADC value and tumor size (r = −0.59, P = 0.004) and between ADC value and number of metastatic lymph nodes (r = −0.56, P = 0.007). Tumors with low ADC value had a significant tendency to show high portal venous system invasion (P = 0.02) and extrapancreatic nerve plexus invasion (P = 0.01).

Conclusions

Apparent diffusion coefficient value appears to be a promising parameter for detecting pancreatic cancer and evaluating the degree of malignancy of pancreatic cancer.

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Title: Correlation of apparent diffusion coefficient measured by diffusion-weighted MRI and clinicopathologic features in pancreatic cancer patients
Authors: Koichi Hayano
Fumihiko Miura
Hodaka Amano
Naoyuki Toyota
Keita Wada
Kenichiro Kato
Keiji Sano
Koji Takeshita
Tomoyoshi Aoyagi
Kiyohiko Shuto
Hisahiro Matsubara
Takehide Asano
Tadahiro Takada
Publication date: 01-02-2013
Publisher: Springer Japan
Published in: Journal of Hepato-Biliary-Pancreatic Sciences / Issue 2/2013
Print ISSN: 1868-6974
Electronic ISSN: 1868-6982
DOI: https://doi.org/10.1007/s00534-011-0491-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Correlation of apparent diffusion coefficient measured by diffusion-weighted MRI and clinicopathologic features in pancreatic cancer patients

Abstract

Background/purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background/purpose

Methods

Results

Conclusions

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