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01-06-2013 | Diagnostic Neuroradiology

Correlation between pulmonary function and brain volume in healthy elderly subjects

Authors: Yasuyuki Taki, Shigeo Kinomura, Satoru Ebihara, Benjamin Thyreau, Kazunori Sato, Ryoi Goto, Masako Kakizaki, Ichiro Tsuji, Ryuta Kawashima, Hiroshi Fukuda

Published in: Neuroradiology | Issue 6/2013

Abstract

Introduction

Cigarette smoking decreases brain regional gray matter volume and is related to chronic obstructive lung disease (COPD). COPD leads to decreased pulmonary function, which is represented by forced expiratory volume in one second percentage (FEV1.0 %); however, it is unclear if decreased pulmonary function is directly related to brain gray matter volume decline. Because there is a link between COPD and cognitive decline, revealing a direct relationship between pulmonary function and brain structure is important to better understand how pulmonary function affects brain structure and cognitive function. Therefore, the purpose of this study was to analyze whether there were significant correlations between FEV1.0 % and brain regional gray and white matter volumes using brain magnetic resonance (MR) image data from 109 community-dwelling healthy elderly individuals.

Methods

Brain MR images were processed with voxel-based morphometry using a custom template by applying diffeomorphic anatomical registration using the exponentiated lie algebra procedure.

Results

We found a significant positive correlation between the regional white matter volume of the cerebellum and FEV1.0 % after adjusting for age, sex, and intracranial volume.

Conclusion

Our results suggest that elderly individuals who have a lower FEV1.0 % have decreased regional white matter volume in the cerebellum. Therefore, preventing decreased pulmonary function is important for cerebellar white matter volume in the healthy elderly population.

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Title: Correlation between pulmonary function and brain volume in healthy elderly subjects
Authors: Yasuyuki Taki
Shigeo Kinomura
Satoru Ebihara
Benjamin Thyreau
Kazunori Sato
Ryoi Goto
Masako Kakizaki
Ichiro Tsuji
Ryuta Kawashima
Hiroshi Fukuda
Publication date: 01-06-2013
Publisher: Springer-Verlag
Published in: Neuroradiology / Issue 6/2013
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-013-1157-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Correlation between pulmonary function and brain volume in healthy elderly subjects

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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