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01-03-2011 | Thoracic Oncology

Correlation Between gp96 Expression and the Surgical Outcome in Patients With Esophageal Squamous Cell Carcinoma

Authors: Yasunori Akutsu, MD, PhD, Hisahiro Matsubara, MD, PhD, Masayuki Kano, MD, PhD, Akihiro Usui, MD, PhD, Yasuo Yoneyama, MD, PhD, Norimasa Ikeda, MD, Aki Komatsu, BS, Gulbostan Yusup, MD

Published in: Annals of Surgical Oncology | Issue 3/2011

Abstract

Background

Heat-shock protein gp96 plays an important role in antitumor immunoreactions. Gp96 has a close relationship with antitumor immunity. This study evaluated the correlation between gp96 expression and the prognosis in esophageal squamous cell carcinoma.

Methods

Seventy-eight patients with primarily resected esophageal squamous cell carcinoma were enrolled onto this study, and gp96 expression was evaluated by immunohistochemical staining. The association of clinicopathological factors and patients’ survival was calculated by univariate (log rank test) and multivariate (Cox proportional hazard regression method) analyses.

Results

Fifty-seven (73%) of 78 cases were gp96 positive, and 21 were negative (27%). The survival of patients with gp96-negative disease was significantly shorter (5-year survival, 22.9 months) than with gp96-positive disease (45.8 months; P = 0.049), and the multivariate analysis showed that gp96 negativity is an independent risk factor for poor survival (hazard ratio, 2.577; P = 0.040). Gp96-negative cases had more metastatic lymph nodes than did negative cases, especially in T1 cases (4.8 in gp96-negative cases vs. 0.84 in gp96-positive cases; P = 0.064)

Conclusions

The downregulation of gp96 expression is closely correlated with poor survival in esophageal squamous cell carcinoma.

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Title: Correlation Between gp96 Expression and the Surgical Outcome in Patients With Esophageal Squamous Cell Carcinoma
Authors: Yasunori Akutsu, MD, PhD
Hisahiro Matsubara, MD, PhD
Masayuki Kano, MD, PhD
Akihiro Usui, MD, PhD
Yasuo Yoneyama, MD, PhD
Norimasa Ikeda, MD
Aki Komatsu, BS
Gulbostan Yusup, MD
Publication date: 01-03-2011
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 3/2011
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-010-1128-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Correlation Between gp96 Expression and the Surgical Outcome in Patients With Esophageal Squamous Cell Carcinoma

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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