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European Radiology
Published in: European Radiology 7/2016

01-07-2016 | Breast

Correlation between conductivity and prognostic factors in invasive breast cancer using magnetic resonance electric properties tomography (MREPT)

Authors: Soo-Yeon Kim, Jaewook Shin, Dong-Hyun Kim, Min Jung Kim, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon

Published in: European Radiology | Issue 7/2016

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Abstract

Purpose

To investigate the correlation between conductivity and prognostic factors of invasive breast cancer using magnetic resonance electric properties tomography (MREPT).

Methods

This retrospective study was approved by the Institutional Review Board, and verbal informed consent was obtained prior to breast MRI. This study included 65 women with surgically confirmed invasive breast cancers measuring 1 cm or larger on T2-weighted fast spin echo (FSE). Phase-based MREPT and the coil combination technique were used to reconstruct conductivity. Simple and multiple linear regression analysis were used to find an independent factor associated with conductivity.

Results

In total tumours, tumours with HER-2 overexpression showed lower conductivity than those without, and HER-2 overexpression was independently associated with conductivity. In 37 tumours 2 cm or larger, tumours with high mitosis or PR positivity showed higher conductivity than those without, and high mitosis and PR positivity were independently associated with conductivity. In 28 tumours 1–2 cm in size, there were no differences in conductivity according to the prognostic factors.

Conclusion

Conductivity values measured using MREPT are associated with the HER-2 overexpression status, and may provide information about mitosis and the PR status of invasive breast cancers 2 cm or larger.

Key Points

• In all tumours, HER-2 overexpression was independently associated with conductivity.
• In tumours ≥ 2 cm, high mitosis and PR positivity were associated with conductivity.
• Conductivity is associated with the HER-2 overexpression status of invasive breast cancers.
Appendix
Available only for authorised users
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Metadata
Title
Correlation between conductivity and prognostic factors in invasive breast cancer using magnetic resonance electric properties tomography (MREPT)
Authors
Soo-Yeon Kim
Jaewook Shin
Dong-Hyun Kim
Min Jung Kim
Eun-Kyung Kim
Hee Jung Moon
Jung Hyun Yoon
Publication date
01-07-2016
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 7/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-015-4067-7

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