Top

European Journal of Medical Research

Published in:

Open Access 01-12-2018 | Research

Correlation analysis on serum inflammatory cytokine level and neurogenic pulmonary edema for children with severe hand–foot–mouth disease

Authors: Jin-Fang Sun, Hao-Lan Li, Bao-Xia Sun

Published in: European Journal of Medical Research | Issue 1/2018

Abstract

Objective

This study aims to discuss the correlation between serum inflammatory cytokines and neurogenic pulmonary edema (NPE) in children with severe hand–foot–mouth disease (HFMD).

Methods

A total of 89 patients with severe HFMD were enrolled into this study. These patients were divided into two groups, according to the presence of NPE: central nervous system disease (CNSD) group and NPE group. Serum IL-4, IL-10, IL-6, IL-17, tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) levels were measured in patients by enzyme-linked immunosorbent assay at 1, 3, and 5 days after admission. Furthermore, risk factors for NPE were screened using multivariable logistic regression analysis.

Results

IL-6, TNF-α, IL-10, and interferon-γ (IFN-γ) levels in the NPE group were higher than in the CNSD group. TNF-α, IL-10, and IFN-γ levels reached a peak on the 3rd day of admission. Age, continuous fever, blood sugar, white blood cell count, and IL-10 were risk factors for the occurrence of NPE in severe HFMD.

Conclusion

The dynamic unbalance of inflammatory cytokines is related to the occurrence and progress of NPE.

Nadel S. Hand, foot, mouth, brainstem, and heart disease resulting from enterovirus 71. Crit Care Med. 2013;41(7):1821–2.CrossRefPubMed

Gong X, Zhou J, Zhu W, Liu N, Li J, Li L, Jin Y, Duan Z. Excessive pro-inflammatory cytokine responses of human monocyte-derived macrophages to enterovirus 71 infection. BMC Infect Dis. 2012;12:224.CrossRefPubMedPubMedCentral

Wang W, Li W, Yang X, Zhang T, Wang Y, Zhong R, Jiao Y, Li T, Jiang T, Tian Y, Wu H. Interleukin-8 is elevated in severe hand, foot, and mouth disease. J Infect Dev Ctries. 2014;8(1):94–100.CrossRefPubMed

Wang SM, Lei HY, Liu CC. Cytokine immunopathogenesis of enterovirus 71 brainstem encephalitis. Clin Dev Immunol. 2012;2012:876241.PubMedPubMedCentral

Zhang Y, Liu H, Wang L, Yang F, Hu Y, Ren X, Li G, Yang Y, Sun S, Li Y, Chen X, Li X, Jin Q. Comparative study of the cytokine/chemokine response in children with differing disease severity in enterovirus 71-induced hand, foot, and mouth disease. PLoS ONE. 2013;8(6):e67430.CrossRefPubMedPubMedCentral

Zeng M, Zheng X, Wei R, Zhang N, Zhu K, Xu B, Yang CH, Yang CF, Deng C, Pu D, Wang X, Altmeyer R, Leng Q. The cytokine and chemokine profiles in patients with hand, foot and mouth diseases of different severities in Shanghai, China, 2010. PLoS Negl Trop Dis. 2013;7(12):e2599.CrossRefPubMedPubMedCentral

Ministry of Health of the People’s Republic of China. HFMD prevention and control guidance in 2008. Chin J Exp Clin Infect Dis. 2008;2(3):210–3.

Li S, Cai C, Feng J, Li X, Wang Y, Yang J, Chen Z. Peripheral T lymphocyte subset imbalances in children with enterovirus 71-induced hand, foot and mouth disease. Virus Res. 2014;180:84–91.CrossRefPubMed

Jiang T, Li SJ, Ouyang WX, Tan YF, Liu FR, Xiao GJ, Tang L, Zhang H. Changes in Thl7 and CD4+CD25+Treg ceHs and their significance among children with hand, foot and mouth disease. Zhongguo Dang Dai Er Ke Za Zhi. 2013;15(12):1113–5.PubMed

10.

Wei R, Xu L, Zhang N, Zhu K, Yang J, Yang C, Deng C, Zhu Z, De Groot AS, Altmeyer R, Zeng M, Leng Q. Elevated antigen-specific Th2 type response is associated with the poor prognosis of hand, foot and mouth disease. Virus Res. 2013;177(1):62–5.CrossRefPubMed

11.

Huang YY, Luo Y, Zhang JS, Wei LJ. Changes of tumor necrosis factor-α, interleukin-1β and cytokine induced neutrophil chemoattractant-1 in aqueous humor of rabbits with traumatic endophthalmitis. Recent Adv Ophthalmol. 2013;33(8):713–6.

12.

Yang YJ, Yang YL, Xu CL. Effects of diabetes mellitus on posterior capsule opacification and its possible mechanism. Recent Adv Ophthalmol. 2014;34(5):474–7.

13.

Fu XY, Zou WJ, Yu Q. Effects of doxycycline on IL-1 and TNF-α in rat alkali burn corneas. Recent Adv Ophthalmol. 2014;34(10):915–7.

14.

Yang J, Zhao N, Su NL, Sun JL, Lv TG, Chen ZB. Association of interleukin 1 0 and interferon gamma gene polymorphisms with enterovirus 71 encephalitis in patients with hand, foot and mouth disease. Scand J Infect Dis. 2012;44(6):465–9.CrossRefPubMed

15.

Han J, Wang Y, Gan X, Song J, Sun P, Dong XP. Serum cytokine profiles of children with human enterovirus 71-associated hand, foot, and mouth disease. J Med Virol. 2014;86(8):1377–85.CrossRefPubMed

16.

Li W, Teng G, Tong H, Jiao Y, Zhang T, Chen H, Wu H. Study on risk factors for severe hand, foot and mouth disease in China. PLoS ONE. 2014;9(1):e87603.CrossRefPubMedPubMedCentral

17.

Yang T, Xu G, Dong H, Ye M, He T. A case-control study of risk factors for severe hand–foot–mouth disease among children in Ningbo, China, 2010–2011. Eur J Pediatr. 2012;171(9):1359–64.CrossRefPubMed

18.

Sui JL, Wang XY, Li HT. Case–control study on risk factors of severe hand–foot–mouth disease. Pract Prev Med. 2012;19(10):1486–8.

19.

Hao B, Gao D, Tang DW, Wang XG, Liu SP, Kong XP, Liu C, Huang JL, Bi QM, Quan L, Luo B. Distribution of human enterovirus 71 in brainstem of infants with brain stem encephalitis and infection mechanism. Fa Yi Xue Za Zhi. 2012;28(2):85–91.PubMed

20.

Junttila E, Ala-Kokko T, Ohtonen P, Vaarala A, Karttunen A, Vuolteenaho O, Salo T, Sutinen M, Karhu T, Herzig KH, Koskenkari J. Neumgenic pulmonary edema in patients with nontraumatic intracerebral hemorrhage: predictors and association with outcome. Anesth Analg. 2013;116(4):855–61.CrossRefPubMed

Title: Correlation analysis on serum inflammatory cytokine level and neurogenic pulmonary edema for children with severe hand–foot–mouth disease
Authors: Jin-Fang Sun
Hao-Lan Li
Bao-Xia Sun
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: European Journal of Medical Research / Issue 1/2018
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/s40001-018-0313-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Correlation analysis on serum inflammatory cytokine level and neurogenic pulmonary edema for children with severe hand–foot–mouth disease

Abstract

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 1/2018

Is total femoral replacement for non-oncologic and oncologic indications a safe procedure in limb preservation surgery? A single center experience of 22 cases

Chemokine ligand–receptor interactions critically regulate cutaneous wound healing

Impact of anticoagulation and vasoactive medication on regained radial artery patency after catheterization: a case–control study

Correction to: High sensitivity troponin T and I reflect mitral annular plane systolic excursion being assessed by cardiac magnetic resonance imaging

Clinical evaluation of haploidentical hematopoietic combined with human umbilical cord-derived mesenchymal stem cells in severe aplastic anemia

Direct comparison of coronary bare metal vs. drug-eluting stents: same platform, different mechanics?