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01-09-2009 | Rapid Communication

Correlating Metabolic Activity with Cellular Proliferation in Follicular Lymphomas

Authors: Bingfeng Tang, Jozef Malysz, Vonda Douglas-Nikitin, Richard Zekman, Regina Heather Wong, Ishmael Jaiyesimi, Ching-yee Oliver Wong

Published in: Molecular Imaging and Biology | Issue 5/2009

Abstract

Purpose

The aim of this study was to correlate metabolic behavior of follicular lymphoma with proliferative index (Ki67).

Materials and Methods

Pre-treatment 2-deoxy-2-[F-18]fluoro-d-glucose positron emission tomography–computed tomography scans of 23 patients with pathologic diagnosis of follicular lymphoma were retrospectively analyzed together with Ki67. The maximal standardized uptake value (SUV) was measured and corrected to glucose level of 100 mg/dl over the biopsy region (BxSUV100) and at the highest tumor activity of the body (BmSUV100).

Results

BxSUV100 was significantly correlated with Ki67 (p = 0.037). There was an increasing trend of metabolic activity across the pathologic grades of follicular lymphomas. BmSUV100 and BxSUV100 were also significantly different (p < 0.0005), suggesting potential pitfalls of sampling error by histology.

Conclusion

The increasing trend of metabolic activity across follicular lymphoma grades correlates with cellular proliferation. The metabolic information from positron emission tomography–computed tomography may offer another useful parameter in the management of follicular lymphomas.

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Title: Correlating Metabolic Activity with Cellular Proliferation in Follicular Lymphomas
Authors: Bingfeng Tang
Jozef Malysz
Vonda Douglas-Nikitin
Richard Zekman
Regina Heather Wong
Ishmael Jaiyesimi
Ching-yee Oliver Wong
Publication date: 01-09-2009
Publisher: Springer-Verlag
Published in: Molecular Imaging and Biology / Issue 5/2009
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI: https://doi.org/10.1007/s11307-009-0226-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Correlating Metabolic Activity with Cellular Proliferation in Follicular Lymphomas

Abstract

Purpose

Materials and Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Materials and Methods

Results

Conclusion

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