Top

Published in:

Open Access 01-12-2020 | Coronavirus | Review

The role of passive immunization in the age of SARS-CoV-2: an update

Authors: Johannes C. Fischer, Kurt Zänker, Martijn van Griensven, Marion Schneider, Detlef Kindgen-Milles, Wolfram Trudo Knoefel, Artur Lichtenberg, Balint Tamaskovics, Freddy Joel Djiepmo-Njanang, Wilfried Budach, Stefanie Corradini, Ute Ganswindt, Dieter Häussinger, Torsten Feldt, Hubert Schelzig, Hans Bojar, Matthias Peiper, Edwin Bölke, Jan Haussmann, Christiane Matuschek

Published in: European Journal of Medical Research | Issue 1/2020

Abstract

The rapid spread of the corona virus pandemic is an existential problem for many people in numerous countries. So far, there is no effective vaccine protection or proven therapy available against the SARS-CoV-2 virus. In this review, we describe the role of passive immunization in times of the corona virus. Passive immunization could be a bridging technology to improve the immune defense of critically ill patients until better approaches with effective medications are available.

Kruse RL. Therapeutic strategies in an outbreak scenario to treat the novel coronavirus originating in Wuhan, China. F1000Res. 2020;9:72.CrossRef

Shen C, Wang Z, Zhao F, et al. Treatment of 5 critically Ill patients with COVID-19 With convalescent plasma. JAMA. 2020;323(16):1582–9.CrossRef

Bloch EM, Shoham S, Casadevall A, et al. Deployment of convalescent plasma for the prevention and treatment of COVID-19. J Clin Invest. 2020. https://doi.org/10.1172/JCI138745.CrossRef

Chen L, Xiong J, Bao L, Shi Y. Convalescent plasma as a potential therapy for COVID-19. Lancet Infect Dis. 2020;20:398–400.CrossRef

Duan K, Liu B, Li C, et al. Effectiveness of convalescent plasma therapy in severe COVID-19 patients. Proc Natl Acad Sci USA. 2020;117(17):9490–6.CrossRef

Keith P, Day M, Perkins L, Moyer L, Hewitt K, Wells A. A novel treatment approach to the novel coronavirus: an argument for the use of therapeutic plasma exchange for fulminant COVID-19. Crit Care. 2020;24:128.CrossRef

Roback JD, Guarner J. Convalescent plasma to treat COVID-19: possibilities and challenges. JAMA. 2020. https://doi.org/10.1001/jama.2020.4940.CrossRef

Tanne JH. Covid-19: FDA approves use of convalescent plasma to treat critically ill patients. BMJ. 2020;368:m1256.CrossRef

Tiberghien P, de Lambalerie X, Morel P, Gallian P, Lacombe K, Yazdanpanah Y. Collecting and evaluating convalescent plasma for COVID-19 treatment: why and how. Vox Sang. 2020. https://doi.org/10.1111/vox.12926.CrossRef

10.

Ye M, Fu D, Ren Y, et al. Treatment with convalescent plasma for COVID-19 patients in Wuhan, China. J Med Virol. 2020. https://doi.org/10.1002/jmv.25882.CrossRef

11.

Ahn JY, Sohn Y, Lee SH, et al. Use of convalescent plasma therapy in two COVID-19 patients with acute respiratory distress syndrome in Korea. J Korean Med Sci. 2020;35:e.149.CrossRef

12.

Thevarajan I, Nguyen THO, Koutsakos M, et al. Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19. Nat Med. 2020;26:453.CrossRef

13.

Ziegler-Heitbrock L. The CD14 + CD16 + blood monocytes: their role in infection and inflammation. J Leukoc Biol. 2007;81:584–92.CrossRef

14.

Xu Z, Shi L, Wang Y, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020;8:420–2.CrossRef

15.

Moon C. Fighting COVID-19 exhausts T cells. Nat Rev Immunol. 2020. https://doi.org/10.1038/s41577-020-0304-7.CrossRef

16.

Mehta P, McAuley DF, Brown M, et al. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020;395:1033–4.CrossRef

17.

Vaninov N. In the eye of the COVID-19 cytokine storm. Nat Rev Immunol. 2020. https://doi.org/10.1038/s41577-020-0305-6.CrossRef

18.

Matzinger P. The danger model: a renewed sense of self. Science. 2002;296:301–5.CrossRef

19.

Schneider EM, Flacke S, Liu F, et al. Autophagy and ATP-induced anti-apoptosis in antigen presenting cells (APC) follows the cytokine storm in patients after major trauma. J Cell Commun Signal. 2011;5:145–56.CrossRef

20.

Schneider EM. Bullfight without killers: interferon rules pathology in HLH. Blood. 2004;104:600–1.CrossRef

21.

Chen G, Wu D, Guo W, et al. Clinical and immunologic features in severe and moderate coronavirus disease 2019. J Clin Invest. 2020. https://doi.org/10.1172/JCI137244.CrossRef

22.

Mao L, Jin H, Wang M, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol. 2020. https://doi.org/10.1001/jamaneurol.2020.1127.CrossRef

23.

Bosch JA, Fischer JE, Fischer JC. Psychologically adverse work conditions are associated with CD8 + T cell differentiation indicative of immunesenescence. Brain Behav Immun. 2009;23:527–34.CrossRef

24.

Wang H, Zhang L. Risk of COVID-19 for patients with cancer. Lancet Oncol. 2020;21:e181.CrossRef

25.

Wei W, Jiang H, Chen W, et al. How should we implement radiotherapy for cancer patients in China during the endemic period of COVID-19? Radiother Oncol. 2020;147:100–2.CrossRef

26.

Zhang L, Zhu F, Xie L, et al. Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China. Ann Oncol. 2020. https://doi.org/10.1016/j.annonc.2020.03.296.CrossRef

27.

Zhong Z, Zhang Q, Xia H, et al. Clinical characteristics and immunosuppressants management of coronavirus disease 2019 in solid organ transplant recipients. Am J Transplant. 2020. https://doi.org/10.1111/ajt.15928.CrossRef

28.

Boyarsky BJ, Chiang TP, Werbel WA, et al. Early impact of COVID-19 on transplant center practices and policies in the United States. Am J Transplant. 2020. https://doi.org/10.1111/ajt.15915.CrossRef

Title: The role of passive immunization in the age of SARS-CoV-2: an update
Authors: Johannes C. Fischer
Kurt Zänker
Martijn van Griensven
Marion Schneider
Detlef Kindgen-Milles
Wolfram Trudo Knoefel
Artur Lichtenberg
Balint Tamaskovics
Freddy Joel Djiepmo-Njanang
Wilfried Budach
Stefanie Corradini
Ute Ganswindt
Dieter Häussinger
Torsten Feldt
Hubert Schelzig
Hans Bojar
Matthias Peiper
Edwin Bölke
Jan Haussmann
Christiane Matuschek
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Coronavirus
SARS-CoV-2
COVID-19
Published in: European Journal of Medical Research / Issue 1/2020
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/s40001-020-00414-5

At a glance: The STEP trials

Springer Medicine

The role of passive immunization in the age of SARS-CoV-2: an update

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2020

The effects of aqueous extract of Maca on energy metabolism and immunoregulation

Correction to: The role of passive immunization in the age of SARS-CoV-2: an update

The stability of carbapenems before and after admixture to PMMA-cement used for replacement surgery caused by Gram-negative bacteria

Primary gastroduodenal tuberculosis complicated with acute pancreatitis: a rare case report and literature review

Treatment of the mandibular shift in an adult woman and the diagnostic value of joint space index: a case report

Comparison of three fixation methods for orotracheal intubation in 95 adults