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Chinese Medicine
Published in: Chinese Medicine 1/2018

Open Access 01-12-2018 | Review

Corni Fructus: a review of chemical constituents and pharmacological activities

Authors: Yu Dong, Zhe-Ling Feng, Hu-Biao Chen, Fu-Sheng Wang, Jia-Hong Lu

Published in: Chinese Medicine | Issue 1/2018

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Abstract

Cornus officinalis Sieb. et Zucc. is part of the genus Cornus of the family Cornaceae. Ripening and dry fruits (Corni Fructus) are recognized as an essential herb medicine in the traditional Chinese medicine (TCM) and have been widely used for over 2000 years. This review provides a comprehensive summary of Corni Fructus (CF), including the botany, phytochemistry, traditional use, and current pharmacological activities. According to the basic theory of TCM, CF usually participates in various Chinese medicinal formulae to exert the essential roles in replenishing liver and kidney, arresting seminal emission and sweat. Based on modern pharmacological studies, about 90 compounds have been isolated and identified from CF. In vivo and in vitro experimental studies indicate that CF exhibits extensive pharmacological activities including hypoglycemic, antioxidant, anti-inflammatory, anticancer, neuroprotective, hepatoprotective, and nephroprotective activities. However, only about 18% of chemical constituents in CF were tested. It means the potential pharmacological activities and clinical values of CF need to be further investigated.
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Metadata
Title
Corni Fructus: a review of chemical constituents and pharmacological activities
Authors
Yu Dong
Zhe-Ling Feng
Hu-Biao Chen
Fu-Sheng Wang
Jia-Hong Lu
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Chinese Medicine / Issue 1/2018
Electronic ISSN: 1749-8546
DOI
https://doi.org/10.1186/s13020-018-0191-z

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