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Open Access 01-12-2004 | Research article

Core I gene is overexpressed in Hürthle and non-Hürthle cell microfollicular adenomas and follicular carcinomas of the thyroid

Authors: Valdemar Máximo, Ana Preto, Ana Crespo, Ana Sofia Rocha, José Carlos Machado, Paula Soares, Manuel Sobrinho-Simões

Published in: BMC Cancer | Issue 1/2004

Abstract

Background

Most of the steps involved in the initiation and progression of Hürthle (oncocytic, oxyphilic) cell carcinomas of the thyroid remain unknown.

Methods

Using differential display and semiquantitative RT-PCR we found, among other alterations, overexpression of the gene encoding the Core I subunit of the complex III of the mitochondrial respiratory chain in a follicular carcinoma composed of Hürthle cells.

Results

Similar high levels of Core I gene expression were detected in nine follicular carcinomas (seven with Hürthle cell features), in seven microfollicular adenomas (one with Hürthle cell features) and in one micro/macrofollicular adenoma, in contrast to a lower/normal expression in nine papillary carcinomas (three with Hürthle cell features) and five macrofollicular adenomas (one of which displaying Hürthle cell features). No significative correlation was found between Core I overexpression and the proliferative activity of the lesions.

Conclusions

We conclude that Core I overexpression in thyroid tumours is not associated with malignancy, Hürthle cells or proliferative activity. The pathogenetic mechanism linking Core I overexpression to the microfollicular pattern of growth of thyroid tumours remains to be clarified.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/4/12/prepub

Title: Core I gene is overexpressed in Hürthle and non-Hürthle cell microfollicular adenomas and follicular carcinomas of the thyroid
Authors: Valdemar Máximo
Ana Preto
Ana Crespo
Ana Sofia Rocha
José Carlos Machado
Paula Soares
Manuel Sobrinho-Simões
Publication date: 01-12-2004
Publisher: BioMed Central
Published in: BMC Cancer / Issue 1/2004
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/1471-2407-4-12

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Abstract

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