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Current Heart Failure Reports

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Open Access 15-08-2023

Coordinated Metabolic Responses Facilitate Cardiac Growth in Pregnancy and Exercise

Authors: Emily B. Schulman-Geltzer, Helen E. Collins, Bradford G. Hill, Kyle L. Fulghum

Published in: Current Heart Failure Reports | Issue 5/2023

Abstract

Purpose of Review

Pregnancy and exercise are systemic stressors that promote physiological growth of the heart in response to repetitive volume overload and maintenance of cardiac output. This type of remodeling is distinct from pathological hypertrophy and involves different metabolic mechanisms that facilitate growth; however, it remains unclear how metabolic changes in the heart facilitate growth and if these processes are similar in both pregnancy- and exercise-induced cardiac growth.

Recent Findings

The ability of the heart to metabolize a myriad of substrates balances cardiac demands for energy provision and anabolism. During pregnancy, coordination of hormonal status with cardiac reductions in glucose oxidation appears important for physiological growth. During exercise, a reduction in cardiac glucose oxidation also appears important for physiological growth, which could facilitate shuttling of glucose-derived carbons into biosynthetic pathways for growth. Understanding the metabolic underpinnings of physiological cardiac growth could provide insight to optimize cardiovascular health and prevent deleterious remodeling, such as that which occurs from postpartum cardiomyopathy and heart failure.

Summary

This short review highlights the metabolic mechanisms known to facilitate pregnancy-induced and exercise-induced cardiac growth, both of which require changes in cardiac glucose metabolism for the promotion of growth. In addition, we mention important similarities and differences of physiological cardiac growth in these models as well as discuss current limitations in our understanding of metabolic changes that facilitate growth.

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Title: Coordinated Metabolic Responses Facilitate Cardiac Growth in Pregnancy and Exercise
Authors: Emily B. Schulman-Geltzer
Helen E. Collins
Bradford G. Hill
Kyle L. Fulghum
Publication date: 15-08-2023
Publisher: Springer US
Published in: Current Heart Failure Reports / Issue 5/2023
Print ISSN: 1546-9530
Electronic ISSN: 1546-9549
DOI: https://doi.org/10.1007/s11897-023-00622-0

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Keynote webinar | Spotlight on medication adherence

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Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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Other articles of this Issue 5/2023

Multimorbidity in Heart Failure: Leveraging Cluster Analysis to Guide Tailored Treatment Strategies

Heart failure-related iron deficiency anemia

Perspectives on Secondary Mitral Regurgitation in Heart Failure

Biomarkers in light chain cardiac amyloidosis

Telemedicine: an Effective and Low-Cost Lesson From the COVID-19 Pandemic for the Management of Heart Failure Patients

The Association Between Intra-abdominal Pressure and Diuretic Response in Heart Failure

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

At a glance: The STEP trials