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Breast Cancer Research
Published in: Breast Cancer Research 3/2007

01-06-2007 | Commentary

Cooperation between Wnt and Notch signalling in human breast cancer

Authors: Giovanna M Collu, Keith Brennan

Published in: Breast Cancer Research | Issue 3/2007

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Abstract

The Wnt and Notch signalling pathways play major roles in mammary gland development and tumourigenesis. During development, these pathways have opposing effects. However, in a recent paper Ayyanan and coworkers show that expression of Wnt1 is sufficient to transform primary human mammary epithelial cells, and that this is in part due to activation of the Notch pathway. This indicates that during tumourigenesis the two pathways cooperate. Here we ask why activation of Wnt signalling alone is sufficient to cause transformation; whether there is evidence for inhibitory crosstalk between the pathways during tumourigenesis; and whether cooperation between these pathways occurs in other forms of cancer.
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Metadata
Title
Cooperation between Wnt and Notch signalling in human breast cancer
Authors
Giovanna M Collu
Keith Brennan
Publication date
01-06-2007
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 3/2007
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1671

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