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International Urogynecology Journal
Published in: International Urogynecology Journal 4/2009

01-04-2009 | Original Article

Continued symptom improvement in sexually active women with overactive bladder and urgency urinary incontinence treated with tolterodine ER for 6 months

Authors: Rebecca G. Rogers, Tola Omotosho, Gloria Bachmann, Franklin Sun, Jon D. Morrow

Published in: International Urogynecology Journal | Issue 4/2009

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Abstract

Improvements in overactive bladder (OAB) symptoms and health-related quality of life (HRQL) were assessed during a 24-week study of tolterodine extended release (TOL ER) in sexually active women with OAB and urgency urinary incontinence (UUI). A 12-week, double-blind, randomized, placebo-controlled trial was followed by a 12-week open-label phase. Sexually active women reported symptoms for ≥3 months. Subjects completed bladder diaries and HRQL measures at baseline and weeks 12 and 24. One hundred sixty-one women received TOL ER for 24 weeks. Women reported significant improvements in all end points at week 12 that were maintained or improved at 24 weeks. At week 24, 70% of subjects reported no UUI episodes. TOL ER resulted in improvements in OAB symptoms and HRQL that were maintained or greater with 6 months of use. Long-term compliance with OAB pharmacotherapy may be important for optimal treatment outcomes.
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Metadata
Title
Continued symptom improvement in sexually active women with overactive bladder and urgency urinary incontinence treated with tolterodine ER for 6 months
Authors
Rebecca G. Rogers
Tola Omotosho
Gloria Bachmann
Franklin Sun
Jon D. Morrow
Publication date
01-04-2009
Publisher
Springer-Verlag
Published in
International Urogynecology Journal / Issue 4/2009
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI
https://doi.org/10.1007/s00192-008-0782-9

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