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Current Neurology and Neuroscience Reports

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01-12-2013 | Dementia (KS Marder, Section Editor)

Contemplating Alzheimer’s Disease and the Contribution of White Matter Hyperintensities

Author: Adam M. Brickman

Published in: Current Neurology and Neuroscience Reports | Issue 12/2013

Abstract

As the older adult segment of the population increases, Alzheimer’s disease (AD) has emerged as a significant public health epidemic. Over the past 3 decades, advances in the understanding of the biology of AD have led to a somewhat unified hypothesis of disease pathogenesis that emphasizes the precipitating role of beta amyloid protein. However, several lines of evidence suggest that multiple pathologies are necessary for clinical manifestation of the disease. Our focus over the past several years has been on the contribution of small vessel cerebrovascular disease, visualized as white matter hyperintensities (WMH) on magnetic resonance imaging, to AD. White matter hyperintensity volume, particularly in parietal regions, is elevated among individuals with and at risk for AD, predicts future diagnosis of AD, predicts the rate of progression of cognitive symptoms among individuals with AD, and increases over time among individuals destined to develop AD. White matter hyperintensities may represent an independent source of impairment and/or may interact more fundamentally with “primary” AD pathology. Future work should focus on more inclusive models of that better define “normal” vs “pathological” aging.

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Title: Contemplating Alzheimer’s Disease and the Contribution of White Matter Hyperintensities
Author: Adam M. Brickman
Publication date: 01-12-2013
Publisher: Springer US
Published in: Current Neurology and Neuroscience Reports / Issue 12/2013
Print ISSN: 1528-4042
Electronic ISSN: 1534-6293
DOI: https://doi.org/10.1007/s11910-013-0415-7

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Contemplating Alzheimer’s Disease and the Contribution of White Matter Hyperintensities

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