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01-01-2017 | Original Paper

Constituents from the leaves of Clausena lansium and their anti-inflammatory activity

Authors: De-Yang Shen, Ping-Chung Kuo, Shiow-Chyn Huang, Tsong-Long Hwang, Yu-Yi Chan, Po-Chuen Shieh, Nguyen Thi Ngan, Tran Dinh Thang, Tian-Shung Wu

Published in: Journal of Natural Medicines | Issue 1/2017

Abstract

Five new acyclic amides, clausenalansamides C-G (1–5), clausenaline G (6) and (±)-5-(4-methylphenyl)-γ-valerolactone (7) reported from the natural source for the first time, were characterized from the leaves of Clausena lansium. Their structures were established by spectroscopic and spectrometric methods, and the absolute configurations of new compounds 1–5 were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses. Eighteen compounds were evaluated for their anti-inflammatory activity and only imperatorin (11) and wampetin (12) displayed significant inhibition of fMLP/CB-induced superoxide anion generation with IC₅₀ values of 1.7 ± 0.3 and 6.8 ± 1.1 μM, respectively.

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Title: Constituents from the leaves of Clausena lansium and their anti-inflammatory activity
Authors: De-Yang Shen
Ping-Chung Kuo
Shiow-Chyn Huang
Tsong-Long Hwang
Yu-Yi Chan
Po-Chuen Shieh
Nguyen Thi Ngan
Tran Dinh Thang
Tian-Shung Wu
Publication date: 01-01-2017
Publisher: Springer Japan
Published in: Journal of Natural Medicines / Issue 1/2017
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-016-1033-x

At a glance: The STEP trials

Springer Medicine

Constituents from the leaves of Clausena lansium and their anti-inflammatory activity

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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