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Open Access 01-12-2021 | Constipation | Research

Association of cesarean birth with prevalence of functional constipation in toddlers at 3 years of age: results from the Japan Environment and Children’s Study (JECS)

Authors: Mari Nakamura, Kenta Matsumura, Yoshiko Ohnuma, Taketoshi Yoshida, Akiko Tsuchida, Kei Hamazaki, Hidekuni Inadera, the Japan Environment and Children’s Study Group

Published in: BMC Pediatrics | Issue 1/2021

Abstract

Background

The association between delivery mode and subsequent development of diseases is a growing area of research. Cesarean delivery affects the diversity of the microbiota in the infant gut, which may be associated with gastrointestinal disorders, including functional constipation, in infants. In this study, we investigated the association between delivery mode and prevalence of functional constipation in 3-year-old Japanese toddlers.

Methods

This study used data from the Japan Environment and Children’s Study, an ongoing nationwide birth cohort study. We analyzed 71,878 toddler–mother pairs. The presence of functional constipation was determined according to the Rome III diagnostic criteria. Odds ratios and 95% confidence intervals were calculated using logistic regression analysis.

Results

The prevalence of functional constipation in 3-year-old Japanese toddlers was estimated to be 12.3%. Logistic regression analysis revealed that the prevalence of functional constipation was higher in toddlers born by cesarean delivery (13.1%) compared with those born by vaginal delivery (12.1%), independent of 22 confounders (adjusted odds ratios = 1.064, 95% confidence interval = 1.004–1.128).

Conclusions

We determined the prevalence of functional constipation in 3-year-old Japanese toddlers and found that delivery mode was associated with the prevalence of functional constipation in Japanese toddlers.

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Title: Association of cesarean birth with prevalence of functional constipation in toddlers at 3 years of age: results from the Japan Environment and Children’s Study (JECS)
Authors: Mari Nakamura
Kenta Matsumura
Yoshiko Ohnuma
Taketoshi Yoshida
Akiko Tsuchida
Kei Hamazaki
Hidekuni Inadera
the Japan Environment and Children’s Study Group
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Constipation
Sectio Ceasarea
Respiratory Microbiota
Constipation
Sectio Caesarea
Published in: BMC Pediatrics / Issue 1/2021
Electronic ISSN: 1471-2431
DOI: https://doi.org/10.1186/s12887-021-02885-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association of cesarean birth with prevalence of functional constipation in toddlers at 3 years of age: results from the Japan Environment and Children’s Study (JECS)

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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