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International Journal of Colorectal Disease
Published in: International Journal of Colorectal Disease 1/2021

01-01-2021 | Constipation | Original Article

Colonic diverticular disease in autosomal dominant polycystic kidney disease: is there really an association? A nationwide analysis

Authors: Rodrigo Duarte-Chavez, Jill Stoltzfus, Vikas Yellapu, Noel Martins, Sudip Nanda, Santo Longo, Berhanu Geme, Yecheskel Schneider

Published in: International Journal of Colorectal Disease | Issue 1/2021

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Abstract

Purpose

Colonic diverticulosis, diverticulitis, and diverticular bleeding are reportedly more common in patients with autosomal dominant polycystic kidney disease (ADPKD). Other studies have questioned this association. The objectives of our study are to clarify this association using a larger patient population and to identify risk factors in general to develop diverticular disease.

Methods

The Nationwide Inpatient Sample weighted discharges from 2003 to 2011 were used to assess for the prevalence of diverticular disease in the population with ADPKD compared with the general population without ADPKD. A multivariable direct logistic regression model was constructed to determine independent predictors of diverticular disease in the general population.

Results

The prevalence of diverticulosis, diverticulitis, and diverticular bleeding were considerably increased in patients with ADPKD compared with the general population without ADPKD. The prevalence of colonic surgery was less in ADPKD patients with diverticulitis. In patients with kidney transplant, the prevalence of diverticulitis was increased in the ADPKD group, but colonic surgery was not significantly different between both groups. The prevalence of diverticular bleeding was slightly elevated in patients with ADPKD, but colonic surgery was significantly increased in patients with ADPKD. NSAID use, hypertension, constipation, and ADPKD had increased odds ratios for diverticular disease during multivariate analysis.

Conclusion

There is an increased prevalence of colonic diverticular disease in the population with ADPKD.
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Metadata
Title
Colonic diverticular disease in autosomal dominant polycystic kidney disease: is there really an association? A nationwide analysis
Authors
Rodrigo Duarte-Chavez
Jill Stoltzfus
Vikas Yellapu
Noel Martins
Sudip Nanda
Santo Longo
Berhanu Geme
Yecheskel Schneider
Publication date
01-01-2021
Publisher
Springer Berlin Heidelberg
Published in
International Journal of Colorectal Disease / Issue 1/2021
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-020-03736-2

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