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Neurological Sciences

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01-01-2021 | Constipation | Review Article

Non-motor symptoms are associated with REM sleep behavior disorder in Parkinson’s disease: a systematic review and meta-analysis

Authors: Dan Xie, Qiuyan Shen, Junying Zhou, Yanming Xu

Published in: Neurological Sciences | Issue 1/2021

Abstract

Objective

Parkinson’s disease (PD) is usually accompanied by rapid eye movement sleep behavior disorder (RBD). A systematic review has concluded that motor manifestations are associated with RBD in PD patients, but whether the same is true of non-motor symptoms is unclear.

Methods

A systematic review and meta-analysis was conducted by searching studies related to PD and RBD in PubMed, Web of Science, Embase, and Cochrane databases. Data were pooled where appropriate and used to calculate odds ratios (ORs), mean differences (MDs), or standardized mean differences (SMDs) with 95% confidence intervals (CI). Heterogeneity was assessed using the I² statistic.

Results

PD patients with RBD were more likely to be male (OR 1.26, 95% CI 1.14–1.40) and older (MD 1.70 years, 95% CI 1.24–2.16) than those of patients without RBD. Patients with RBD were at a higher risk of non-motor symptoms such as constipation (OR 1.94, 95% CI 1.57–2.38), hallucination (OR 2.62, 95% CI 2.01–3.41), depression (SMD 0.39, 95% CI 0.25–0.53), and cognitive impairment (SMD − 0.29, 95% CI − 0.42 to − 0.17) based on standardized questionnaire scores. Similarly, PD patients with RBD suffered more severe motor symptoms and required higher doses of levodopa therapy.

Conclusions

The available evidence suggests that PD patients with RBD suffer severer non-motor and motor symptoms than those without RBD. A potential explanation is that PD patients with RBD present more diffuse neurodegeneration.

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Title: Non-motor symptoms are associated with REM sleep behavior disorder in Parkinson’s disease: a systematic review and meta-analysis
Authors: Dan Xie
Qiuyan Shen
Junying Zhou
Yanming Xu
Publication date: 01-01-2021
Publisher: Springer International Publishing
Keywords: Constipation
Mood Disorders
Affective Disorder
Parkinson's Disease
Constipation
Published in: Neurological Sciences / Issue 1/2021
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-020-04769-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Non-motor symptoms are associated with REM sleep behavior disorder in Parkinson’s disease: a systematic review and meta-analysis

Abstract

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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