Skip to main content
Top
Published in: International Urology and Nephrology 1/2007

01-03-2007 | Original Paper

Conservative management of renal masses in the elderly: our experience

Authors: Herman S. Fernando, Sudhir Duvuru, Simon J. Hawkyard

Published in: International Urology and Nephrology | Issue 1/2007

Login to get access

Abstract

Objectives

To analyse a group of patients with clinically and radiologically detected renal neoplasms who were conservatively treated for various reasons. The patients were followed-up radiologically and intervened only if symptomatic. The natural progression of these masses and also a brief review of the literature is done.

Methods

The series was collected retrospectively from the case-notes of patients coded for renal neoplasms. Of the 13 patients followed up conservatively, eight were deferred surgery in view of their age (mean age—83.25 years), one patient had a single kidney, two were unwilling for surgery and two had severe co-morbidities which made them unfit for surgery.

Results

The mean age at diagnosis was 80.4 years (median—82; range 66–88). Seven females and six males were followed up for a mean and median follow-up of 38.38 and 34 months respectively (range—19 to 105 months). Six patients died during follow-up (mean-41.57 months). The average longest dimension at diagnosis and when last reviewed were 5.01 cm and 5.57 cm. However, only one of these died due to metastasis which developed during follow-up and two had to be angio-embolised for hematuria. The average rate of growth along the longitudinal dimension was 0.17 cm/year while the average change in volume was 11.97 cc/year.

Conclusions

Malignant renal neoplasms grow at a relatively slow rate. Without tumour growth the risk of metastasis appears limited. Thus expectant management can be considered as an alternative for a selected group of patients who are either unwilling or unfit or high risk for surgery.
Literature
1.
go back to reference Office for National Statistics (2004) Cancer statistics registrations: registrations of cancer diagnosed in 2001, England. Series MB1 no.32. National Statistics, London Office for National Statistics (2004) Cancer statistics registrations: registrations of cancer diagnosed in 2001, England. Series MB1 no.32. National Statistics, London
2.
go back to reference Landis SH, Murray T, Bolden S, Wingo PA (1999) Cancer statistics: 1999. CA Cancer J Clin 49:8–31PubMed Landis SH, Murray T, Bolden S, Wingo PA (1999) Cancer statistics: 1999. CA Cancer J Clin 49:8–31PubMed
3.
go back to reference Katz DL, Zheng T, Holford TR, Flannery J (1994) Time trends in the incidence of renal carcinoma: analysis of Connecticut Tumor Registry data, 1935–1989. Int J Cancer 58(1):57–63PubMedCrossRef Katz DL, Zheng T, Holford TR, Flannery J (1994) Time trends in the incidence of renal carcinoma: analysis of Connecticut Tumor Registry data, 1935–1989. Int J Cancer 58(1):57–63PubMedCrossRef
4.
go back to reference Chow WH, Devesa SS, Warren JL, Fraumeni JF Jr (1999) Rising incidence of renal cell cancer in the United States. JAMA 281:1628–1631PubMedCrossRef Chow WH, Devesa SS, Warren JL, Fraumeni JF Jr (1999) Rising incidence of renal cell cancer in the United States. JAMA 281:1628–1631PubMedCrossRef
5.
go back to reference Robson CJ, Churchill BM, Anderson W (1969) The results of radical nephrectomy for renal cell carcinoma. J Urol 101(3):297–301PubMed Robson CJ, Churchill BM, Anderson W (1969) The results of radical nephrectomy for renal cell carcinoma. J Urol 101(3):297–301PubMed
6.
go back to reference Lee CT, Katz J, Shi W, Thaler HT, Reuter VE, Russo P (2000) Surgical management of renal tumors 4 cm. or less in a contemporary cohort. J Urol 163(3):730–736PubMedCrossRef Lee CT, Katz J, Shi W, Thaler HT, Reuter VE, Russo P (2000) Surgical management of renal tumors 4 cm. or less in a contemporary cohort. J Urol 163(3):730–736PubMedCrossRef
7.
go back to reference Hellsten S, Johnsen J, Berge T et al (1990) Clinically unrecognised renal cell carcinoma. Diagnostic and pathological aspects. Eur Urol suppl 18:2–3 Hellsten S, Johnsen J, Berge T et al (1990) Clinically unrecognised renal cell carcinoma. Diagnostic and pathological aspects. Eur Urol suppl 18:2–3
8.
go back to reference Bosniak MA (1995) Observation of small incidentally detected renal masses. Semin Urol Oncol 13:267PubMed Bosniak MA (1995) Observation of small incidentally detected renal masses. Semin Urol Oncol 13:267PubMed
9.
go back to reference Bosniak MA, Birnbaum BA, Krinsky GA, Waisman J (1995) Small renal parenchymal neoplasms: further observations on growth. Radiology 197(3):589–597PubMed Bosniak MA, Birnbaum BA, Krinsky GA, Waisman J (1995) Small renal parenchymal neoplasms: further observations on growth. Radiology 197(3):589–597PubMed
10.
go back to reference Rendon RA, Stanietzky N, Panzarella T, Robinette M, Klotz LH, Thurston W, Jewett MA (2000) The natural history of small renal masses. J Urol 164(4):1143–1147PubMedCrossRef Rendon RA, Stanietzky N, Panzarella T, Robinette M, Klotz LH, Thurston W, Jewett MA (2000) The natural history of small renal masses. J Urol 164(4):1143–1147PubMedCrossRef
11.
go back to reference Oda T, Miyao N, Takahashi A, Yanase M, Masumori N, Itoh N, Tamakawa M, Tsukamoto T (2001) Growth rates of primary and metastatic lesions of renal cell carcinoma. Int J Urol 8(9):473–477PubMedCrossRef Oda T, Miyao N, Takahashi A, Yanase M, Masumori N, Itoh N, Tamakawa M, Tsukamoto T (2001) Growth rates of primary and metastatic lesions of renal cell carcinoma. Int J Urol 8(9):473–477PubMedCrossRef
12.
go back to reference Dekernion JB, Ramming KP, Smith RB (1978) The natural history of metastatic renal cell carcinoma: a computer analysis. J Urol 120(2):148–152PubMed Dekernion JB, Ramming KP, Smith RB (1978) The natural history of metastatic renal cell carcinoma: a computer analysis. J Urol 120(2):148–152PubMed
13.
go back to reference Tosaka A, Ohya K, Yamada K, Ohashi H, Kitahara S, Sekine H, Takehara Y, Oka K (1990) Incidence and properties of renal masses and asymptomatic renal cell carcinoma detected by abdominal ultrasonography. J Urol 144(5):1097–1099PubMed Tosaka A, Ohya K, Yamada K, Ohashi H, Kitahara S, Sekine H, Takehara Y, Oka K (1990) Incidence and properties of renal masses and asymptomatic renal cell carcinoma detected by abdominal ultrasonography. J Urol 144(5):1097–1099PubMed
14.
go back to reference Griffiths DF, Verghese A, Golash A, Kynaston HG, Matthews PN, Hart AJ, Court JB (2002) Contribution of grade, vascular invasion and age to outcome in clinically localized renal cell carcinoma. BJU Int 90(1):26–31PubMedCrossRef Griffiths DF, Verghese A, Golash A, Kynaston HG, Matthews PN, Hart AJ, Court JB (2002) Contribution of grade, vascular invasion and age to outcome in clinically localized renal cell carcinoma. BJU Int 90(1):26–31PubMedCrossRef
15.
go back to reference Wehle MJ, Thiel DD, Petrou SP, Young PR, Frank I, Karsteadt N (2004) Conservative management of incidental contrast-enhancing renal masses as safe alternative to invasive therapy. Urology 64(1):49–52PubMedCrossRef Wehle MJ, Thiel DD, Petrou SP, Young PR, Frank I, Karsteadt N (2004) Conservative management of incidental contrast-enhancing renal masses as safe alternative to invasive therapy. Urology 64(1):49–52PubMedCrossRef
16.
go back to reference Kassouf W, Aprikian AG, Laplante M, Tanguay S (2004) Natural history of renal masses followed expectantly. J Urol 171(1):111–113PubMedCrossRef Kassouf W, Aprikian AG, Laplante M, Tanguay S (2004) Natural history of renal masses followed expectantly. J Urol 171(1):111–113PubMedCrossRef
17.
go back to reference Lamb GW, Bromwich EJ, Vasey P, Aitchison M (2004) Management of renal masses in patients medically unsuitable for nephrectomy—natural history, complications, and outcome. Urology 64(5):909–913PubMedCrossRef Lamb GW, Bromwich EJ, Vasey P, Aitchison M (2004) Management of renal masses in patients medically unsuitable for nephrectomy—natural history, complications, and outcome. Urology 64(5):909–913PubMedCrossRef
18.
go back to reference Volpe A, Panzarella T, Rendon RA, Haider MA, Kondylis FI, Jewett MA (2004) The natural history of incidentally detected small renal masses. Cancer 100(4):738–745PubMedCrossRef Volpe A, Panzarella T, Rendon RA, Haider MA, Kondylis FI, Jewett MA (2004) The natural history of incidentally detected small renal masses. Cancer 100(4):738–745PubMedCrossRef
19.
go back to reference Sowery RD, Siemens DR (2004) Growth characteristics of renal cortical tumors in patients managed by watchful waiting. Can J Urol 11(5):2407–2410PubMed Sowery RD, Siemens DR (2004) Growth characteristics of renal cortical tumors in patients managed by watchful waiting. Can J Urol 11(5):2407–2410PubMed
Metadata
Title
Conservative management of renal masses in the elderly: our experience
Authors
Herman S. Fernando
Sudhir Duvuru
Simon J. Hawkyard
Publication date
01-03-2007
Publisher
Kluwer Academic Publishers
Published in
International Urology and Nephrology / Issue 1/2007
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-006-9119-0

Other articles of this Issue 1/2007

International Urology and Nephrology 1/2007 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine