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Published in: Maternal and Child Health Journal 2/2010

01-03-2010

Consanguinity and Adverse Pregnancy Outcomes: The North of Jordan Experience

Authors: Basil R. Obeidat, Yousef S. Khader, Zouhair O. Amarin, Mohammad Kassawneh, Mousa Al Omari

Published in: Maternal and Child Health Journal | Issue 2/2010

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Abstract

This cross-sectional study was carried out to assess the association between consanguineous marriages and adverse pregnancy outcome in the north of Jordan. Women delivered in four major hospitals in the north of Jordan between April 2007 and May 2007 were included in the study. Non-Jordanian women and women with multiple pregnancies were excluded. Mothers answered a pilot-tested structured questionnaire administered by trained personnel in the maternity ward. Data regarding pregnancy outcomes were obtained from the patients’ individual records. A total of 3,269 women with a mean age of 27.2 (SD 6.6) years were included. About 49% of women had consanguineous marriages. Consanguineous marriages were significantly associated with low birth weight delivery (13.9% vs. 10.1%), preterm delivery (19.9% vs. 12.3%), and births with congenital anomalies (4.1% vs. 0.8%) compared with non-consanguineous marriages. In the multivariate analysis, consanguinity was significantly associated with preterm delivery (OR = 1.5, 95% CI 1.2, 1.9), and congenital malformations (OR = 6.5, 95% CI 2.8, 15.3). In conclusions, this study supports the association between consanguinity and some adverse pregnancy outcomes.
Literature
3.
go back to reference Tamim, H., Khogali, M., Beydoun, H., Melki, I., Yunis, K., & National Collaborative Perinatal Neonatal Network. (2003). Consanguinity and apnea of prematurity. American Journal of Epidemiology, 158, 942–946. doi:10.1093/aje/kwg226.CrossRefPubMed Tamim, H., Khogali, M., Beydoun, H., Melki, I., Yunis, K., & National Collaborative Perinatal Neonatal Network. (2003). Consanguinity and apnea of prematurity. American Journal of Epidemiology, 158, 942–946. doi:10.​1093/​aje/​kwg226.CrossRefPubMed
5.
go back to reference Alwan, A., & Modell, B. (1997). Community control of genetic and congenital disorders. EMRO Technical Publication Series 24. Egypt: WHO Regional Office for the Eastern Mediterranean Region. Alwan, A., & Modell, B. (1997). Community control of genetic and congenital disorders. EMRO Technical Publication Series 24. Egypt: WHO Regional Office for the Eastern Mediterranean Region.
8.
go back to reference Mumtaz, G., Tamim, H., Kanaan, M., Khawaja, M., Khogali, M., Wakim, G., et al. (2007). Effect of consanguinity on birth weight for gestational age in a developing country. American Journal of Epidemiology, 165, 742–752. doi:10.1093/aje/kwk108.CrossRefPubMed Mumtaz, G., Tamim, H., Kanaan, M., Khawaja, M., Khogali, M., Wakim, G., et al. (2007). Effect of consanguinity on birth weight for gestational age in a developing country. American Journal of Epidemiology, 165, 742–752. doi:10.​1093/​aje/​kwk108.CrossRefPubMed
10.
go back to reference Yunis, K., Mumtaz, G., Bitar, F., Chamseddine, F., Kassar, M., Rashkidi, J., et al. (2006). Consanguineous marriage and congenital heart defects: A case–control study in the neonatal period. American Journal of Medical Genetics, 140, 1524–1530.PubMed Yunis, K., Mumtaz, G., Bitar, F., Chamseddine, F., Kassar, M., Rashkidi, J., et al. (2006). Consanguineous marriage and congenital heart defects: A case–control study in the neonatal period. American Journal of Medical Genetics, 140, 1524–1530.PubMed
11.
13.
go back to reference Hamamy, H. A., Masri, A. T., Al-Hadidy, A. M., & Ajlouni, K. M. (2007). Consanguinity and genetic disorders. Profile from Jordan. Saudi Medical Journal, 28, 1015–1017.PubMed Hamamy, H. A., Masri, A. T., Al-Hadidy, A. M., & Ajlouni, K. M. (2007). Consanguinity and genetic disorders. Profile from Jordan. Saudi Medical Journal, 28, 1015–1017.PubMed
14.
go back to reference Koury, S. A., & Massad, D. F. (2000). Consanguinity, fertility, reproductive wastage, infant mortality and congenital malformations in Jordan. Saudi Medical Journal, 21, 150–154. Koury, S. A., & Massad, D. F. (2000). Consanguinity, fertility, reproductive wastage, infant mortality and congenital malformations in Jordan. Saudi Medical Journal, 21, 150–154.
15.
go back to reference Hussain, R., Bittles, A. H., & Sullivan, S. (2001). Consanguinity and early mortality in the Muslim populations of India and Pakistan. American Journal of Human Biology, 13, 777–787. doi:10.1002/ajhb.1124.CrossRefPubMed Hussain, R., Bittles, A. H., & Sullivan, S. (2001). Consanguinity and early mortality in the Muslim populations of India and Pakistan. American Journal of Human Biology, 13, 777–787. doi:10.​1002/​ajhb.​1124.CrossRefPubMed
16.
go back to reference Stoltenberg, C., Magnus, P., Skrondal, A., & Lie, R. T. (1999). Consanguinity and recurrence risk of stillbirth and infant death. American Journal of Public Health, 89, 517–523.CrossRefPubMed Stoltenberg, C., Magnus, P., Skrondal, A., & Lie, R. T. (1999). Consanguinity and recurrence risk of stillbirth and infant death. American Journal of Public Health, 89, 517–523.CrossRefPubMed
17.
go back to reference Jaber, L., Merlob, P., Gabriel, R., & Shohat, M. (1997). Effects of consanguineous marriage on reproductive outcome in an Arab community in Israel. American Journal of Medical Genetics, 34, 1000–1002.CrossRef Jaber, L., Merlob, P., Gabriel, R., & Shohat, M. (1997). Effects of consanguineous marriage on reproductive outcome in an Arab community in Israel. American Journal of Medical Genetics, 34, 1000–1002.CrossRef
19.
go back to reference Saad, F. A., & Jauniaux, E. (2002). Recurrent early pregnancy loss and consanguinity. Reproductive Biomedicine Online, 5, 167–170.PubMedCrossRef Saad, F. A., & Jauniaux, E. (2002). Recurrent early pregnancy loss and consanguinity. Reproductive Biomedicine Online, 5, 167–170.PubMedCrossRef
20.
go back to reference Pedersen, J. (2002). The influence of consanguineous marriage on infant and child mortality among Palestinians in the West Bank and Gaza, Jordan, Lebanon and Syria. Community Genetics, 5, 178–181. doi:10.1159/000066333.CrossRefPubMed Pedersen, J. (2002). The influence of consanguineous marriage on infant and child mortality among Palestinians in the West Bank and Gaza, Jordan, Lebanon and Syria. Community Genetics, 5, 178–181. doi:10.​1159/​000066333.CrossRefPubMed
21.
go back to reference Bacon, C., & Fryers, P. (1994). Infant death and consanguineous marriage. BMJ (Clinical Research Ed.), 308, 980. Bacon, C., & Fryers, P. (1994). Infant death and consanguineous marriage. BMJ (Clinical Research Ed.), 308, 980.
22.
go back to reference Orstavik, K. H., Lindemann, R., & Steen, J. (1994). Infant death and consanguineous marriage. BMJ (Clinical Research Ed.), 308, 659. Orstavik, K. H., Lindemann, R., & Steen, J. (1994). Infant death and consanguineous marriage. BMJ (Clinical Research Ed.), 308, 659.
23.
go back to reference al Husain, M., & al Bunyan, M. (1997). Consanguineous marriages in a Saudi population and the effect of inbreeding on prenatal and postnatal mortality. Annals of Tropical Paediatrics, 17, 155–160.PubMed al Husain, M., & al Bunyan, M. (1997). Consanguineous marriages in a Saudi population and the effect of inbreeding on prenatal and postnatal mortality. Annals of Tropical Paediatrics, 17, 155–160.PubMed
25.
go back to reference Stunkard, A., & Albaum, J. (1981). The accuracy of self-reported weights. The American Journal of Clinical Nutrition, 31, 1593–1599. Stunkard, A., & Albaum, J. (1981). The accuracy of self-reported weights. The American Journal of Clinical Nutrition, 31, 1593–1599.
28.
go back to reference Kulkarni, M. L., & Kurian, M. (1990). Consanguinity and its effect on growth and development: A South Indian study. Journal of Medical Genetics, 27(6), 348–352.CrossRefPubMed Kulkarni, M. L., & Kurian, M. (1990). Consanguinity and its effect on growth and development: A South Indian study. Journal of Medical Genetics, 27(6), 348–352.CrossRefPubMed
29.
go back to reference Nath, A., Patil, C., & Naik, V. A. (2004). Prevalence of consanguineous marriages in a rural community and its effect on pregnancy outcome. Indian Journal of Community Medicine, 29, 1–3. Nath, A., Patil, C., & Naik, V. A. (2004). Prevalence of consanguineous marriages in a rural community and its effect on pregnancy outcome. Indian Journal of Community Medicine, 29, 1–3.
Metadata
Title
Consanguinity and Adverse Pregnancy Outcomes: The North of Jordan Experience
Authors
Basil R. Obeidat
Yousef S. Khader
Zouhair O. Amarin
Mohammad Kassawneh
Mousa Al Omari
Publication date
01-03-2010
Publisher
Springer US
Published in
Maternal and Child Health Journal / Issue 2/2010
Print ISSN: 1092-7875
Electronic ISSN: 1573-6628
DOI
https://doi.org/10.1007/s10995-008-0426-1

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