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Open Access 01-12-2021 | Conjunctivitis | Case report

Vernal keratoconjunctivitis in twins: case report and literature review

Authors: Maria Cristina Artesani, Mariacristina Esposito, Maurizio Mennini, Marco Andreani, Franco Locatelli, Luca Buzzonetti, Alessandro Fiocchi

Published in: Italian Journal of Pediatrics | Issue 1/2021

Excerpt

Vernal keratoconjunctivitis (VKC) is a chronic bilateral seasonal allergic inflammatory disease with a prevalence of < 1 case out of 10,000 in Europe [1], which occurs mainly in pediatric age. The diagnosis is generally confirmed by the finding at the ocular examination of conjunctival hyperemia, papillary hypertrophy in the tarsal conjunctiva, giant papillae and Trantas dots in the limbus region. …

Vichyanond P, Pacharn P, Pleyer U, Leonardi A. Vernal keratoconjunctivitis: a severe allergic eye disease with remodeling changes. Pediatr Allergy Immunol. 2014;25(4):314–22. https://doi.org/10.1111/pai.12197.CrossRefPubMed

Pucci N, Azari C, Vierucci A. La cheratocongiuntivite vernal. Riv Immunol Allergol Pediatr. 2007;2:37–44.

Zicari AM, Mora B, Lollobrigida V, Occasi F, Cesoni Marcelli A, Megiorni F, et al. Immunogenetic investigation in vernal keratoconjunctivitis. Pediatr Allergy Immunol. 2014;25(5):508–10. https://doi.org/10.1111/pai.12231.CrossRefPubMed

Bonini S, Sacchetti M, Mantelli F, Lambiase A. Clinical grading of vernal keratoconjunctivitis. Curr Opin Allergy Clin Immunol. 2007;7(5):436–41. https://doi.org/10.1097/ACI.0b013e3282efb726.CrossRefPubMed

Bonini S, Bonini S, Lambiase A, Magrini L, Rumi C, del Prete G, et al. Vernal keratoconjunctivitis: a model of 5q cytokine gene cluster disease. Int Arch Allergy Immunol. 1995;107(1–3):95–8. https://doi.org/10.1159/000236942.CrossRefPubMed

Zicari AM, Brindisi G, De Castro G, Lollobrigida V, Nebbioso M, Duse M. Is oxidative stress involved in vernal keratoconjunctivitis? Results from a pilot study in children. Pediatr Allergy Immunol. 2020;31(Suppl 26):52–6. https://doi.org/10.1111/pai.13382.CrossRefPubMed

Rosenthal WN, Insler MS. Vernal keratoconjunctivitis: new corneal findings in fraternal twins. Cornea. 1984-1985;3(4):288–90.CrossRef

Al-Okour KR, Odat TA. Vernal keratoconjunctivitis clinical features and complications in 123 patients in Gaza strip. JRMS. 2014;21(1):55–62. https://doi.org/10.12816/0002580.CrossRef

Darrell RW. Superior limbic keratoconjunctivitis in identical twins. Cornea. 1992;11(3):262–3. https://doi.org/10.1097/00003226-199205000-00013.CrossRefPubMed

10.

Murakami Y, Matsui S, Kijima A, Kitaba S, Murota H, Katayama I. Cedar pollen aggravates atopic dermatitis in childhood monozygotic twin patients with allergic rhino conjunctivitis. Allergol Int. 2011;60(3):397–400. https://doi.org/10.2332/allergolint.10-CR-0268.CrossRefPubMed

Title: Vernal keratoconjunctivitis in twins: case report and literature review
Authors: Maria Cristina Artesani
Mariacristina Esposito
Maurizio Mennini
Marco Andreani
Franco Locatelli
Luca Buzzonetti
Alessandro Fiocchi
Publication date: 01-12-2021
Publisher: BioMed Central
Keyword: Conjunctivitis
Published in: Italian Journal of Pediatrics / Issue 1/2021
Electronic ISSN: 1824-7288
DOI: https://doi.org/10.1186/s13052-021-01073-w

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Vernal keratoconjunctivitis in twins: case report and literature review

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