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01-02-2016 | Original Article

Congenital heart defects among Down syndrome patients: a clinical profiling

Authors: Ali Akbar Poursadegh Zonouzi, Najmeh Ahangari, Shahrokh Rajai, Ahmad Poursadegh Zonouzi, Masoud Akbarzadeh Laleh, Azim Nejatizadeh

Published in: Journal of Public Health | Issue 1/2016

Abstract

Aim

The incidence of Down syndrome (DS) has been estimated one case in 814 live births in Iranian population. Congenital heart defects (CHDs) are a major cause of morbidity and mortality in DS patients ranges from 40 to 60 %. To the author’s knowledge, there is no data available for the prevalence and types of CHD in patients with DS in south of Iran. Accordingly, this study aimed to determine the prevalence of CHD among DS patients, and to evaluate the 14 clinical features in DS patients with and without CHD.

Subjects and methods

In the current study, a total of 110 patients diagnosed with DS (55 individuals with CHD and 55 without CHD) were included after postnatal cytogenetic analysis. The demographic and clinical features of all subjects were collected using a precodified questionnaire and clinical examination and then were analyzed using SPSS software.

Results

We found that the atrial septal defect (ASD) was the most common defect accounting for 41.82 % of DS followed by patent ductus arteriosis (PDA) (20 %), ventricular septal defect (VSD; 14.54 %), atrioventricular septal defect (AVSD; 12.73 %) and tetralogy of fallot (TOF; 10.91 %) in our population. Indeed, our results showed that pulmonary hypertension and low set ear clinical manifestations were significantly associated with CHD in DS patients (P < 0.05).

Conclusion

We found that the ASD is the most common CHD seen in DS patients. In addition, our results add to the existing body of evidence that pulmonary hypertension significantly associated with CHD in DS patients. We believe this clinical profiling can become the baseline for intervention in reducing the mortality and morbidity secondary to CHD among DS in our population.

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Title: Congenital heart defects among Down syndrome patients: a clinical profiling
Authors: Ali Akbar Poursadegh Zonouzi
Najmeh Ahangari
Shahrokh Rajai
Ahmad Poursadegh Zonouzi
Masoud Akbarzadeh Laleh
Azim Nejatizadeh
Publication date: 01-02-2016
Publisher: Springer Berlin Heidelberg
Published in: Journal of Public Health / Issue 1/2016
Print ISSN: 2198-1833
Electronic ISSN: 1613-2238
DOI: https://doi.org/10.1007/s10389-015-0696-1

2024 ASCO Annual Meeting

Springer Medicine

Congenital heart defects among Down syndrome patients: a clinical profiling

Abstract

Aim

Subjects and methods

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Aim

Subjects and methods

Results

Conclusion

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