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01-04-2011 | Short Report

Congenital acute lymphoblastic leukemia: a two-case report and a review of the literature

Authors: Ma Pilar Bas Suárez, Jezabel López Brito, Candelaria Santana Reyes, Manuel Gresa Muñoz, Rosario Diaz Pulido, Jose Carlos Lodos Rojas

Published in: European Journal of Pediatrics | Issue 4/2011

Abstract

Congenital leukemia is a rare disease with particular biological and clinical characteristics which differs from those of older children and adults. Here, we describe two cases of congenital acute lymphoblastic leukemia in two newborns with different clinical presentations (leukemia cutis vs. splenomegaly and respiratory distress) and fatal outcome. Both cases shared the expression of myeloid antigens (CD65) and cytogenetic disorders involving the MLL gene (location 11q23) which are associated to extremely poor prognosis.

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Title: Congenital acute lymphoblastic leukemia: a two-case report and a review of the literature
Authors: Ma Pilar Bas Suárez
Jezabel López Brito
Candelaria Santana Reyes
Manuel Gresa Muñoz
Rosario Diaz Pulido
Jose Carlos Lodos Rojas
Publication date: 01-04-2011
Publisher: Springer-Verlag
Published in: European Journal of Pediatrics / Issue 4/2011
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-010-1339-8

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Congenital acute lymphoblastic leukemia: a two-case report and a review of the literature

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