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Open Access 01-06-2024 | Confusion | Correspondence

Pineal parenchymal tumors of intermediate differentiation: in need of a stringent definition to avoid confusion. Scientific commentary on ‘Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics’

Published in: Acta Neuropathologica | Issue 1/2024

Excerpt

In their recent publication in Acta Neuropathologica, Rahmanzade, et al., described a new subgroup of pineal parenchymal tumor of intermediate differentiation (PPTID), suggested to be referred as ‘PPTID-C’ [8]. Their interesting study raises a very critical issue regarding the terminology of pineal parenchymal tumors (PPTs): what neoplasm should be named PPTID? …

Fevre-Montange M, Szathmari A, Champier J, Mokhtari K, Chretien F, Coulon A et al (2008) Pineocytoma and pineal parenchymal tumors of intermediate differentiation presenting cytologic pleomorphism: a multicenter study. Brain Pathol 18:354–359. https://doi.org/10.1111/j.1750-3639.2008.00128.xCrossRefPubMedPubMedCentral

Jouvet A, Saint-Pierre G, Fauchon F, Privat K, Bouffet E, Ruchoux MM et al (2000) Pineal parenchymal tumors: a correlation of histological features with prognosis in 66 cases. Brain Pathol 10:49–60. https://doi.org/10.1111/j.1750-3639.2000.tb00242.xCrossRefPubMed

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Lee JC, Mazor T, Lao R, Wan E, Diallo AB, Hill NS et al (2019) Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma. Acta Neuropathol 137:851–854. https://doi.org/10.1007/s00401-019-01990-5CrossRefPubMedPubMedCentral

Liu APY, Li BK, Pfaff E, Gudenas B, Vasiljevic A, Orr BA et al (2021) Clinical and molecular heterogeneity of pineal parenchymal tumors: a consensus study. Acta Neuropathol 141:771–785. https://doi.org/10.1007/s00401-021-02284-5CrossRefPubMedPubMedCentral

Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (2007) WHO Classification of Tumours of the Central Nervous System, 4th edn. International Agency for Research on Cancer, Lyon

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Rahmanzade R, Pfaff E, Banan R, Sievers P, Suwala AK, Hinz F, Bogumil H, Cherkezov A, Kaan AF, Schrimpf D et al (2023) Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics. Acta Neuropathol https://doi.org/10.1007/s00401-023-02638-1

WHO Classification of Tumours Editorial Board (2021) World Health Organization Classification of Tumours of the Central Nervous System, 5th edn. International Agency for Research on Cancer, Lyon

10.

Yamashita S, Takeshima H, Hata N, Uchida H, Shinojima N, Yokogami K et al (2023) Clinicopathologic analysis of pineal parenchymal tumors of intermediate differentiation: a multi-institutional cohort study by the Kyushu Neuro-Oncology Study Group. J Neurooncol 162:425–433. https://doi.org/10.1007/s11060-023-04310-wCrossRefPubMed

Title: Pineal parenchymal tumors of intermediate differentiation: in need of a stringent definition to avoid confusion. Scientific commentary on ‘Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics’
Publication date: 01-06-2024
Keywords: Confusion
Pineal Tumor
Published in: Acta Neuropathologica / Issue 1/2024
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-024-02684-3

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