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Published in:

01-07-2010

Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection

Authors: Scheherazade Sadegh-Nasseri, Sateesh Natarajan, Chih-Ling Chou, Isamu Z. Hartman, Kedar Narayan, AeRyon Kim

Published in: Immunologic Research | Issue 1-3/2010

Abstract

T cells bearing αβ receptors recognize antigenic peptides bound to class I and class II glycoproteins encoded in the major histocompatibility complex (MHC). Cytotoxic and helper T cells respond respectively to peptide antigens derived from endogenous sources presented by MHC class I, and exogenous sources presented by MHC II, on antigen presenting cells. Differences in the MHC class I and class II structures and their maturation pathways have evolved to optimize antigen presentation to their respective T cells. A main focus of our laboratory is on efforts to understand molecular events in processing of antigen for presentation by MHC class II. The different stages of MHC class II—interactions with molecular chaperons involved in folding and traffic from the ER through the antigen-loading compartments, peptide exchange, and transport to the cell surface have been investigated. Through intense research on biophysical and biochemical properties of MHC class II molecules, we have learned that the conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection, and a determinant of the ability of MHC class II to participate in peptide association or dissociation and interaction with the peptide editor HLA-DM.

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Title: Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection
Authors: Scheherazade Sadegh-Nasseri
Sateesh Natarajan
Chih-Ling Chou
Isamu Z. Hartman
Kedar Narayan
AeRyon Kim
Publication date: 01-07-2010
Publisher: Humana Press Inc
Published in: Immunologic Research / Issue 1-3/2010
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-009-8138-1

2024 ASCO Annual Meeting

Springer Medicine

Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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