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01-08-2007 | Short Communication

Confirmation of region-specific patterns of gene expression in the human brain

Authors: Carl Ernst, Adolfo Sequeira, Tim Klempan, Neil Ernst, Jarlath ffrench-Mullen, Gustavo Turecki

Published in: Neurogenetics | Issue 3/2007

Abstract

The human brain is divided and categorized in different ways, yet a molecular genetic approach to region specificity does not exist. Using data from 12 healthy control subjects across 18 brain regions, we performed a microarray analysis using both the HG-U133AB and HG-U133 plus 2 chips for each subject to determine molecular targets showing region specificity. Using a previously published data as our guide, we confirm SIX3, GPR6, SH3RF2, and hSyn as molecular markers of the nucleus accumbens and gamma-aminobutyric-acid A receptor alpha-6, Nik-related kinase, and eomesodermin as molecular markers of the cerebellum.

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Title: Confirmation of region-specific patterns of gene expression in the human brain
Authors: Carl Ernst
Adolfo Sequeira
Tim Klempan
Neil Ernst
Jarlath ffrench-Mullen
Gustavo Turecki
Publication date: 01-08-2007
Publisher: Springer-Verlag
Published in: Neurogenetics / Issue 3/2007
Print ISSN: 1364-6745
Electronic ISSN: 1364-6753
DOI: https://doi.org/10.1007/s10048-007-0084-2

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Confirmation of region-specific patterns of gene expression in the human brain

Abstract

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