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01-04-2014 | Case Report

Concurrent presentation of nodal myeloid sarcoma and bone marrow chronic lymphocytic leukemia/small lymphocytic lymphoma: a unique association

Authors: Vasilios Perifanis, Michael D. Diamantidis, Kyriaki Chalvatzi, Vassiliki Kaloutsi, Dimitra Markala, Virginia Voulgaridou, Pavlina Pantelidou, Athinodoros Pavlidis, George Stavrou, Georgia Kaiafa

Published in: International Journal of Hematology | Issue 4/2014

Abstract

Myeloid sarcoma (MS), previously known as granulocytic sarcoma, is a rare, localized, tumor mass composed of myeloid precursor cells, with or without maturation, and occurring at an anatomical site other than the bone marrow (BM). Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), in contrast, is a B-cell hematological malignancy. We describe the first reported case of concurrent presentation of nodal MS and of BM CLL/SLL in the same patient. Fatal leukemic central nervous system infiltration was the final outcome. We provide possible explanations and investigate the pathophysiology of this unique, previously unreported co-morbidity.

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Title: Concurrent presentation of nodal myeloid sarcoma and bone marrow chronic lymphocytic leukemia/small lymphocytic lymphoma: a unique association
Authors: Vasilios Perifanis
Michael D. Diamantidis
Kyriaki Chalvatzi
Vassiliki Kaloutsi
Dimitra Markala
Virginia Voulgaridou
Pavlina Pantelidou
Athinodoros Pavlidis
George Stavrou
Georgia Kaiafa
Publication date: 01-04-2014
Publisher: Springer Japan
Published in: International Journal of Hematology / Issue 4/2014
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI: https://doi.org/10.1007/s12185-014-1508-z

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