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Critical Care
Published in: Critical Care 3/2013

01-06-2013 | Letter

Concomitant assessment of PSP and NT-proCNP as predictive markers of sepsis in severe trauma patients under mechanical ventilation

Authors: Aurélie Gouel-Chéron, Maryline Dupin, Marine Chanteperdix, Isabelle Chaillol, Fabienne Venet, Alexandre Pachot, Guillaume Monneret, Bernard Floccard, Bernard Allaouchiche

Published in: Critical Care | Issue 3/2013

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Excerpt

In intensive care units (ICUs), a great deal of research is devoted to finding new biomarkers to help physicians in the prediction of outcome. The pancreatic stone protein/regenerating protein (PSP) [1, 2] and the amino terminal pro-C-type-natriuretic-peptide (NT-proCNP) [3] were assessed as markers of sepsis in patients with moderate trauma and as prognostic markers of mortality for PSP [4]. The objective of this study was to analyze separately the roles of these two biomarkers in the prediction of sepsis in patients with severe trauma. …
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Literature
1.
Keel M, Harter L, Reding T, Sun LK, Hersberger M, Seifert B, Bimmler D, Graf R: Pancreatic stone protein is highly increased during posttraumatic sepsis and activates neutrophil granulocytes. Crit Care Med 2009, 37: 1642-1648. 10.1097/CCM.0b013e31819da7d6CrossRefPubMed
2.
Llewelyn MJ, Berger M, Gregory M, Ramaiah R, Taylor AL, Curdt I, Lajaunias F, Graf R, Blincko SJ, Drage S, Cohen J: Sepsis biomarkers in unselected patients on admission to intensive or high-dependency care. Crit Care 2013, 17: R60. 10.1186/cc12588PubMedCentralCrossRefPubMed
3.
Bahrami S, Pelinka L, Khadem A, Maitzen S, Hawa G, van Griensven M, Redl H: Circulating NT-proCNP predicts sepsis in multiple-traumatized patients without traumatic brain injury. Crit Care Med 2010, 38: 161-166. 10.1097/CCM.0b013e3181b78a06CrossRefPubMed
4.
Boeck L, Graf R, Eggimann P, Pargger H, Raptis DA, Smyrnios N, Thakkar N, Siegemund M, Rakic J, Tamm M, Stolz D: Pancreatic stone protein: a marker of organ failure and outcome in ventilator-associated pneumonia. Chest 2011, 140: 925-932. 10.1378/chest.11-0018CrossRefPubMed
Metadata
Title
Concomitant assessment of PSP and NT-proCNP as predictive markers of sepsis in severe trauma patients under mechanical ventilation
Authors
Aurélie Gouel-Chéron
Maryline Dupin
Marine Chanteperdix
Isabelle Chaillol
Fabienne Venet
Alexandre Pachot
Guillaume Monneret
Bernard Floccard
Bernard Allaouchiche
Publication date
01-06-2013
Publisher
BioMed Central
Published in
Critical Care / Issue 3/2013
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc12702

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