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01-12-2014 | Original Article

Concept of left atrial pressure estimation using its pulsatile amplitude in the helical flow total artificial heart

Authors: Sheng-Yuan Wu, Itsuro Saito, Takashi Isoyama, Yusuke Inoue, Masami Sato, Shintaro Hara, Xin-Yang Li, Terumi Yurimoto, Haruka Murakami, Yukino Kawase, Toshiya Ono, Yusuke Abe

Published in: Journal of Artificial Organs | Issue 4/2014

Abstract

The total artificial heart (TAH) requires physiological control to respond to the metabolic demand of the body. To date, 1/R control is a single physiological control method that can control venous pressure. To realize an implantable 1/R control system, we are developing a new pressure measuring method using absolute pressure sensor. To find a method for absolute pressure sensor, which went well without calibration, concept of left atrial pressure (LAP) estimation using its pulsatile amplitude was proposed. Its possibility was investigated with two long-term survived goats whose hearts were replaced with the helical flow TAHs. In manual control condition, there existed a positive relation between mean LAP (mLAP) and normalized pulsatile amplitude (NPA). Percent systole revealed not to affect the relationship between mLAP and NPA. Dispersion was observed between different pulse rates. As for cardiac output difference (QLD) that is the difference of flow rate between systolic and diastolic phases, similar results were obtained except in low QLDs. In the 1/R control condition, relatively high correlation between mLAP and NPA could be obtained. In estimation of mLAP using the correlating function of individual goat, fairly good correlation was obtained between measured mLAP and estimated mLAP. Despite that further studies are necessary, it was demonstrated that the concept of the LAP estimation could be possible.

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Title: Concept of left atrial pressure estimation using its pulsatile amplitude in the helical flow total artificial heart
Authors: Sheng-Yuan Wu
Itsuro Saito
Takashi Isoyama
Yusuke Inoue
Masami Sato
Shintaro Hara
Xin-Yang Li
Terumi Yurimoto
Haruka Murakami
Yukino Kawase
Toshiya Ono
Yusuke Abe
Publication date: 01-12-2014
Publisher: Springer Japan
Published in: Journal of Artificial Organs / Issue 4/2014
Print ISSN: 1434-7229
Electronic ISSN: 1619-0904
DOI: https://doi.org/10.1007/s10047-014-0788-7

At a glance: The STEP trials

Springer Medicine

Concept of left atrial pressure estimation using its pulsatile amplitude in the helical flow total artificial heart

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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