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European Radiology
Published in: European Radiology 6/2011

01-06-2011 | Chest

Computer-aided detection of pulmonary embolism at CT pulmonary angiography: can it improve performance of inexperienced readers?

Authors: Kevin N. Blackmon, Charles Florin, Luca Bogoni, Joshua W. McCain, James D. Koonce, Heon Lee, Gorka Bastarrika, Christian Thilo, Philip Costello, Marcos Salganicoff, U. Joseph Schoepf

Published in: European Radiology | Issue 6/2011

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Abstract

Purpose

To evaluate the effect of a computer-aided detection (CAD) algorithm on the performance of novice readers for detection of pulmonary embolism (PE) at CT pulmonary angiography (CTPA).

Materials and Methods

We included CTPA examinations of 79 patients (50 female, 52 ± 18 years). Studies were evaluated by two independent inexperienced readers who marked all vessels containing PE. After 3 months all studies were reevaluated by the same two readers, this time aided by CAD prototype. A consensus read by three expert radiologists served as the reference standard. Statistical analysis used χ2 and McNemar testing.

Results

Expert consensus revealed 119 PEs in 32 studies. For PE detection, the sensitivity of CAD alone was 78%. Inexperienced readers’ initial interpretations had an average per-PE sensitivity of 50%, which improved to 71% (p < 0.001) with CAD as a second reader. False positives increased from 0.18 to 0.25 per study (p = 0.03). Per-study, the readers initially detected 27/32 positive studies (84%); with CAD this number increased to 29.5 studies (92%; p = 0.125).

Conclusion

Our results suggest that CAD significantly improves the sensitivity of PE detection for inexperienced readers with a small but appreciable increase in the rate of false positives.
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Metadata
Title
Computer-aided detection of pulmonary embolism at CT pulmonary angiography: can it improve performance of inexperienced readers?
Authors
Kevin N. Blackmon
Charles Florin
Luca Bogoni
Joshua W. McCain
James D. Koonce
Heon Lee
Gorka Bastarrika
Christian Thilo
Philip Costello
Marcos Salganicoff
U. Joseph Schoepf
Publication date
01-06-2011
Publisher
Springer-Verlag
Published in
European Radiology / Issue 6/2011
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-010-2050-x

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