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Osteoporosis International
Published in: Osteoporosis International 2/2014

01-02-2014 | Original Article

Comparison of vertebral bone marrow fat assessed by 1H MRS and inphase and out-of-phase MRI among family members

Authors: X. Ojanen, R. J. H. Borra, M. Havu, S. M. Cheng, R. Parkkola, P. Nuutila, M. Alen, S. Cheng

Published in: Osteoporosis International | Issue 2/2014

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Abstract

Summary

Inphase and out-of-phase magnetic resonance imaging is a robust and fast method which can provide similar vertebral bone marrow fat estimation as 1H proton magnetic resonance spectroscopy, indicating that this technique is a potentially useful tool in both research and clinical practice.

Introduction

The importance of evaluating bone marrow fat lies in the fact that osteoporosis and obesity, two disorders of body composition, are growing in prevalence. Bone fat mass can be reliably assessed using proton magnetic resonance spectroscopy (1H MRS), but this method is technically demanding and needs advanced post-processing unlike inphase and out-of-phase magnetic resonance imaging (MRI), which is a robust and fast method.

Methods

We compared vertebral bone marrow fat (BMF) content assessed by inphase and out-of-phase MRI and 1H MRS using a 1.5-T MRI scanner in mothers (n = 34, aged 49.4 years), fathers (n = 31, aged 53.1 years) and their daughters (n = 40, aged 20.3 years) who participated in the CALEX family study. Signal intensity on the inphase and out-of-phase MRI was analyzed from the same location and size of the single-voxel 1H MRS measurement.

Results

Positive correlations were found between 1H MRS and inphase and out-of-phase MRI in the axial plane (r = 0.746, p < 0.001) and sagittal plane (r = 0.804, p < 0.001). The mean differences between 1H MRS and inphase and out-of-phase MRI in the axial and sagittal planes were relatively small, at 4.13 and 2.67 %, and the agreement between techniques was 89.4 and 93.2 %, respectively. Girls had a significantly lower vertebral BMF than mothers and fathers with both methods (for all, p < 0.001).

Conclusions

We conclude that inphase and out-of-phase MRI can provide similar vertebral BMF estimation as 1H MRS, indicating that this technique is a potentially useful tool in both research and clinical practice.
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Metadata
Title
Comparison of vertebral bone marrow fat assessed by 1H MRS and inphase and out-of-phase MRI among family members
Authors
X. Ojanen
R. J. H. Borra
M. Havu
S. M. Cheng
R. Parkkola
P. Nuutila
M. Alen
S. Cheng
Publication date
01-02-2014
Publisher
Springer London
Published in
Osteoporosis International / Issue 2/2014
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-013-2472-9

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