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Pediatric Nephrology

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01-11-2016 | Brief Report

Comparison of two different modes of molecular adsorbent recycling systems for liver dialysis

Authors: Euan Soo, Anja Sanders, Karlheinz Heckert, Tobias Vinke, Franz Schaefer, Claus Peter Schmitt

Published in: Pediatric Nephrology | Issue 11/2016

Abstract

Background

In children acute liver failure is a rare but life-threatening condition from which two-thirds do not recover with supportive therapy. Treatment is limited by the availability of liver transplants. Molecular adsorbent recirculating system (MARS) dialysis is a bridge to transplantation that enhances the chances of survival during the waiting period for a transplant, although it cannot improve survival. Open albumin dialysis (OPAL) is a new mode of albumin dialysis developed to further improve dialysis efficiency.

Case diagnosis/treatment

We report a paediatric case of acute-on-chronic liver failure and compare the two modes of albumin dialysis, namely, the MARS and OPAL, used to treat this patient’s cholestatic pruritus. Removal of total and direct bilirubin, ammonia and bile acids were measured by serial blood tests. There was an increased removal of bile acids with the OPAL mode, whereas the removal of total and direct bilirubin and ammonia was similar in both modes. The patient reported better improvement in pruritus following OPAL compared to dialysis with the MARS.

Conclusion

OPAL may offer a better solution than the MARS in the treatment of refractory pruritus in liver failure.

Available only for authorised users

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Title: Comparison of two different modes of molecular adsorbent recycling systems for liver dialysis
Authors: Euan Soo
Anja Sanders
Karlheinz Heckert
Tobias Vinke
Franz Schaefer
Claus Peter Schmitt
Publication date: 01-11-2016
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 11/2016
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-016-3451-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Comparison of two different modes of molecular adsorbent recycling systems for liver dialysis

Abstract

Background

Case diagnosis/treatment

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case diagnosis/treatment

Conclusion

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