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Open Access 01-11-2012 | Clinical Trials

Comparison of tolerability and efficacy of a combination of paracetamol + caffeine and sumatriptan in the treatment of migraine attack: a randomized, double-blind, double-dummy, cross-over study

Authors: Luigi Alberto Pini, Simona Guerzoni, Michela Cainazzo, Michela Ciccarese, Maria Pia Prudenzano, Paolo Livrea

Published in: The Journal of Headache and Pain | Issue 8/2012

Abstract

In this study, we compared the efficacy and tolerability of the combination of paracetamol 1,000 mg + caffeine 130 mg (PCF) with sumatriptan 50 mg (SUM) in migraine attacks. This was a multi-center randomized double-blind, double-dummy, cross-over controlled trial. The efficacy was assessed by the sum of pain intensity differences, the curve of mean pain intensity, the number of pain free at 2 h, and the total pain relief. Tolerability was assessed by recording adverse events within 4 h after drug assumption and evaluating the global judgement of patients. The comparison of these parameters did not show differences between the two drugs which resulted absolutely overlapping in pain relief and patients evaluation. In conclusion, we confirm the efficacy and safety of PCF such as SUM in the treatment of migraine attacks.

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Title: Comparison of tolerability and efficacy of a combination of paracetamol + caffeine and sumatriptan in the treatment of migraine attack: a randomized, double-blind, double-dummy, cross-over study
Authors: Luigi Alberto Pini
Simona Guerzoni
Michela Cainazzo
Michela Ciccarese
Maria Pia Prudenzano
Paolo Livrea
Publication date: 01-11-2012
Publisher: Springer Milan
Published in: The Journal of Headache and Pain / Issue 8/2012
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1007/s10194-012-0484-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Comparison of tolerability and efficacy of a combination of paracetamol + caffeine and sumatriptan in the treatment of migraine attack: a randomized, double-blind, double-dummy, cross-over study

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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