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International Journal of Colorectal Disease
Published in: International Journal of Colorectal Disease 5/2010

01-05-2010 | Original Article

Comparison of the erectile function in male patients with rectal cancer treated by preoperative radiotherapy followed by surgery and surgery alone

Authors: Phil Hyun Song, Sang Mo Yun, Jae Hwang Kim, Ki Hak Moon

Published in: International Journal of Colorectal Disease | Issue 5/2010

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Abstract

Purpose

This study evaluates the erectile function of male patients treated by preoperative radiotherapy followed by surgery and surgery alone for locally advanced rectal cancer.

Methods

A total of 112 men treated by total mesorectal excision with autonomic nerve preservation were included. Seventy-three patients were treated by preoperative radiotherapy followed by surgery (RTS group), and 39 were treated by surgery alone (surgery group). Patients filled out the five-item version of the international index of erectile function (IIEF-5) questionnaire at least 6 months after initial erectile function assessment. We analyzed the impact of age, surgery type, location, and size of tumor on erectile function.

Results

Total score was decreased significantly at follow-up compared to initial assessment in both RTS and surgery group (20.31 ± 4.39 vs. 11.52 ± 4.83, P = 0.012; 19.86 ± 4.61 vs. 14.07 ± 6.37, P = 0.031, respectively). Score difference was statistically higher in RTS group compared with surgery group (P = 0.028). In terms of surgery type for RTS group, score difference was statistically higher in the patients with abdominoperineal resection (APR) compared with those with lower anterior resection (P = 0.023). In comparison of score difference according to tumor location, difference was statistically higher in the patients with lower rectal cancer compared with those with upper rectal cancer (P = 0.017).

Conclusion

The erectile functions of patients treated by preoperative radiotherapy followed by surgery are more affected than that of patients treated by surgery alone in locally advanced rectal cancer. Also APR and lower rectal cancer were significantly associated with erectile dysfunction in the patients treated by preoperative radiotherapy followed by surgery.
Literature
1.
Farouk R, Nelson H, Gunderson L (1997) Aggressive treatment for locally advanced irresectable rectal cancer. Br J Surg 84:741–749CrossRefPubMed
2.
Nesbakken A, Nygaard K, Bull-Njaa CE, Eri LM (2000) Bladder and sexual dysfunction after mesorectal excision for rectal cancer. Br J Surg 87:206–210CrossRefPubMed
3.
Kim KH, Jessup JM, Beard CJ, Bornstein B, Cady B, Stone MD et al (1997) Locally advanced rectal carcinoma: pelvic control and morbidity following preoperative radiation therapy, resection, and intraoperative radiation therapy. Int J Radiat Oncol Biol Phys 38:777–783CrossRefPubMed
4.
Sauer R, Becker H, Hohenberger W, Rodel C, Wittekind C, Fietkau R et al (2004) Preoperative versus postoperative chemoraiotherapy for rectal cancer. N Engl J Med 351:1731–1740CrossRefPubMed
5.
Havenga K, Deruiter MC, Enker WA, Welvaart K (1996) Anatomical basis of autonomic nerve preserving total mesorectal excision for rectal cancer. Br J Surg 83:384–388CrossRefPubMed
6.
Leveckis J, Boucher NR, Parys BT, Reed MWR, Shorthouse AJ, Anderson JB (1995) Bladder and erectile dysfunction before and after rectal surgery for cancer. Br J Urol 76:752–756PubMed
7.
Enker WE (1992) Potency, cure, and local control in the operative treatment of rectal cancer. Arch Surg 127:1396–1402PubMed
8.
Chatwin NA, Ribordy M, Givel JC (2002) Clinical outcomes and quality of life after low anterior resection for rectal cancer. Eur J Surg 168:297–301CrossRefPubMed
9.
Schmidt CE, Bestmann B, Kuchler T, Kremer B (2005) Factors influencing sexual function in patients with rectal cancer. Int J Impot Res 17:231–238CrossRefPubMed
10.
Heald RJ, Moran BJ, Ryall RDH, Sexton R, MacFarlane JKI (1998) The Basingstoke experience of total mesorectal excision, 1978–1997. Arch Surg 133:894–899CrossRefPubMed
11.
Sugihara K, Kobayashi H, Kato T, Mori T, Mochizuki H, Kameoka S et al (2006) Indication and benefit of pelvic sidewall dissection for rectal cancer. Dis Colon Rectum 49:1663–1672CrossRefPubMed
12.
Koukouras D, Spilliotis J, Scopa CD, Dragotis K, Kalfarentzos F, Tzoracoleftherakis E et al (1991) Radical consequences in the sexuality of male patients operated for colorectal carcinoma. Eur J Surg Oncol 17:285–288PubMed
13.
Mannaerts GHH, Martijn H, Crommelin MA, Dries W, Repelaer van Driel OJ, Rutten HJT (2000) Feasibility and first results of multimodality treatment, combing EBRT, extensive surgery and IOERT in locally advanced primary rectal cancer. Int J Radiat Oncol Biol Phys 47:425–433CrossRefPubMed
14.
Hojo K, Vernava AM III, Sugihara K, Katumata K (1991) Preservation of urine voiding and sexual functioning after rectal cancer surgery. Dis Colon Rect 34:532–539CrossRef
15.
Havenga K, Maas CP, DeRuiter MC, Welvaart K, Trimbos JB (2000) Avoiding long-term disturbance to bladder and sexual function in pelvic surgery, particularly with rectal cancer. Semin Surg Oncol 18:235–243CrossRefPubMed
16.
Marijnen CA, van de Velde CJ, Putter H, van den Brink M, Maas CP, Martijn H et al (2005) Impact of short-term preoperative radiotherapy on health-related quality of life and sexual functioning in primary rectal cancer: report of multicenter randomized trial. J Clin Oncol 23:1847–1858CrossRefPubMed
17.
Pollack J, Holm T, Cedermark B, Altman D, Holmstrom B, Glimelius B et al (2006) Late adverse effects of short-course preoperative radiotherapy in rectal cancer. Br J Surg 93:1519–1525CrossRefPubMed
18.
Hall SJ, Basile G, Bertero EB, de las Morenas A, Goldstein J (1995) Extensive corporeal fibrosis after penile irradiation. J Urol 153:372–377CrossRefPubMed
19.
de Kort SJ, Willemse PH, Habraken JM, de Haes HC, Willems DL, Richel DJ (2006) Quality of life versus prolongation of life in patients treated with chemotherapy in advanced colorectal cancer: a review of randomized controlled clinical trials. Eur J Cancer 42:835–845CrossRefPubMed
20.
Rosen RC, Cappelleri JC, Smith MD, Lipsky J, Pena BM (1999) Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res 11:319–326CrossRefPubMed
21.
Ahn TY, Lee DS, Kang W, Hong JH, Kim YS (2001) Validation of an abridged Korean version of the international index of erectile function (IIEF-5) as a diagnostic tool for erectile dysfunction. Korean J Urol 42:535–540
22.
Maurer CA, Z’Graggen K, Renzulli P, Schilling MK, Netzer P, Buchler MW (2001) Total mesorectal excision preserves male genital function compared with conventional rectal cancer surgery. Br J Surg 88:1501–1505CrossRefPubMed
23.
Engel J, Kerr J, Schlesinger-Raab A, Eckel R, Sauer H, Holzel D (2003) Quality of life in rectal cancer patients: a four-year prospective study. Ann Surg 238:203–213PubMed
24.
Nitori N, Hasegawa H, Ishii Y, Endo T, Kitajima M, Kitagawa Y (2008) Sexual function in men with rectal and rectosigmoid cancer after laparoscopic and open surgery. Hepatogastroenterology 55:1304–1307PubMed
Metadata
Title
Comparison of the erectile function in male patients with rectal cancer treated by preoperative radiotherapy followed by surgery and surgery alone
Authors
Phil Hyun Song
Sang Mo Yun
Jae Hwang Kim
Ki Hak Moon
Publication date
01-05-2010
Publisher
Springer-Verlag
Published in
International Journal of Colorectal Disease / Issue 5/2010
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-010-0879-8

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