Top

BMC Ophthalmology

Published in:

Open Access 01-12-2012 | Research article

Comparison of the efficacy of intravitreal triamcinolone acetonide for cystoid macular edema with versus without serous retinal detachment in branch retinal vein occlusion: influence on macular sensitivity and morphology

Authors: Hidetaka Noma, Hideharu Funatsu, Tatsuya Mimura, Katsunori Shimada

Published in: BMC Ophthalmology | Issue 1/2012

Abstract

Background

The influence of serous retinal detachment (SRD) on visual acuity, macular sensitivity, and macular thickness is unclear after intravitreal injection of triamcinolone acetonide (IVTA) for macular edema with branch retinal vein occlusion (BRVO).

Methods

Twenty-one eyes of 21 BRVO patients with macular edema received IVTA. Patients were divided into two groups by optical coherence tomography findings: 11 patients who had cystoid macular edema (CME) with SRD (SRD (+) group) and 10 patients who had CME without SRD (SRD (−) group). Microperimetry was performed with a Micro Perimeter 1 before and at 3 and 6 months after IVTA. Macular thickness was measured by optical coherence tomography. We exchanged the superior and inferior regions to separate the regions into those with and without occlusion. As a result, the superior region was always the occluded region and the inferior region was non-occluded.

Results

In both the SRD (−) group and the SRD (+) group, the mean macular thickness within the central 4° field and the 10° and 20° fields of the occluded region decreased significantly from baseline to 3 and 6 months after IVTA (all P <0.01). Visual acuity also improved significantly in both groups from baseline to 3 and 6 months after IVTA (both P <0.05). In both groups, the mean macular sensitivity (measured with by microperimetry) within the central 4° field and the 10° and 20° fields of the occluded region showed a significant increase from baseline to 3 and 6 months after IVTA (all P <0.05). The trend profiles of macular thickness within the 10° and 20° fields of the occluded region showed significant differences, but there were no significant differences with respect to the trend profiles of visual acuity and macular sensitivity within the central 4° field and the 10° and 20° fields of the occluded region.

Conclusions

These results suggest that IVTA may achieve more marked improvement of macular morphology in BRVO patients with SRD than in those without SRD, while this therapy may have a similar effect on macular function in BRVO patients with or without SRD.

Available only for authorised users

Michels RG, Gass JD: The natural course of retinal branch vein obstruction. Trans Am Acad Ophthalmol Otolaryngol. 1974, 78: 166-177.

Gutman FA, Zegarra H: The natural course of temporal retinal branch vein occlusion. Trans Am Acad Ophthalmol Otolaryngol. 1974, 78: 178-192.

Noma H, Funatsu H, Sakata K, Harino S, Nagaoka T, Mimura T, Sone T, Hori S: Macular microcirculation and macular oedema in branch retinal vein occlusion. Br J Ophthalmol. 2009, 93: 630-633.CrossRefPubMed

Scott IU, Ip MS, VanVeldhuisen PC, Oden NL, Blodi BA, Fisher M, Chan CK, Gonzalez VH, Singerman LJ, Tolentino M: A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with standard care to treat vision loss associated with macular Edema secondary to branch retinal vein occlusion: the Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) study report 6. Arch Ophthalmol. 2009, 127: 1115-1128.CrossRefPubMedPubMedCentral

Brown DM, Campochiaro PA, Bhisitkul RB, Ho AC, Gray S, Saroj N, Adamis AP, Rubio RG, Murahashi WY: Sustained Benefits from Ranibizumab for Macular Edema Following Branch Retinal Vein Occlusion: 12-Month Outcomes of a Phase III Study. Ophthalmology. 2011, 118: 1594-1602.CrossRefPubMed

Noma H, Funatsu H, Yamasaki M, Tsukamoto H, Mimura T, Sone T, Jian K, Sakamoto I, Nakano K, Yamashita H, Minamoto A, Mishima HK: Pathogenesis of macular edema with branch retinal vein occlusion and intraocular levels of vascular endothelial growth factor and interleukin-6. Am J Ophthalmol. 2005, 140: 256-261.CrossRefPubMed

Noma H, Minamoto A, Funatsu H, Tsukamoto H, Nakano K, Yamashita H, Mishima HK: Intravitreal levels of vascular endothelial growth factor and interleukin-6 are correlated with macular edema in branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol. 2006, 244: 309-315.CrossRefPubMed

Noma H, Funatsu H, Yamasaki M, Tsukamoto H, Mimura T, Sone T, Hirayama T, Tamura H, Yamashita H, Minamoto A, Mishima HK: Aqueous humour levels of cytokines are correlated to vitreous levels and severity of macular oedema in branch retinal vein occlusion. Eye. 2008, 22: 42-48.CrossRefPubMed

Noma H, Funatsu H, Mimura T, Eguchi S, Hori S: Soluble Vascular Endothelial Growth Factor Receptor-2 and Inflammatory Factors in Macular Edema with Branch Retinal Vein Occlusion. Am J Ophthalmol. 2011, 152: 669-677.CrossRefPubMed

10.

Yamaike N, Kita M, Tsujikawa A, Miyamoto K, Yoshimura N: Perimetric sensitivity with the micro perimeter 1 and retinal thickness in patients with branch retinal vein occlusion. Am J Ophthalmol. 2007, 143: 342-344.CrossRefPubMed

11.

Yamaike N, Tsujikawa A, Sakamoto A, Ota M, Kotera Y, Miyamoto K, Kita M, Yoshimura N: Retinal sensitivity after intravitreal injection of bevacizumab for the treatment of macular edema secondary to retinal vein occlusion. Retina. 2009, 29: 757-767.CrossRefPubMed

12.

Noma H, Funatsu H, Mimura T, Harino S, Shimada K: Functional-Morphologic Correlates In Patients With Branch Retinal Vein Occlusion And Macular Edema. Retina. 2011, 31: 2102-2108.CrossRefPubMed

13.

Spaide RF, Lee JK, Klancnik JK, Gross NE: Optical coherence tomography of branch retinal vein occlusion. Retina. 2003, 23: 343-347.CrossRefPubMed

14.

Tsujikawa A, Sakamoto A, Ota M, Kotera Y, Oh H, Miyamoto K, Kita M, Yoshimura N: Serous retinal detachment associated with retinal vein occlusion. Am J Ophthalmol. 2010, 149: 291-301 e5.CrossRefPubMed

15.

Yamaguchi Y, Otani T, Kishi S: Serous macular detachment in branch retinal vein occlusion. Retina. 2006, 26: 1029-1033.CrossRefPubMed

16.

Karacorlu M, Ozdemir H, Karacorlu SA: Resolution of serous macular detachment after intravitreal triamcinolone acetonide treatment of patients with branch retinal vein occlusion. Retina. 2005, 25: 856-860.CrossRefPubMed

17.

Ohashi H, Oh H, Nishiwaki H, Nonaka A, Takagi H: Delayed absorption of macular edema accompanying serous retinal detachment after grid laser treatment in patients with branch retinal vein occlusion. Ophthalmology. 2004, 111: 2050-2056.CrossRefPubMed

18.

Parodi MB, DIS G, Ravalico G: Grid laser treatment for exudative retinal detachment secondary to ischemic branch retinal vein occlusion. Retina. 2008, 28: 97-102.CrossRefPubMed

19.

Noma H, Funatsu H, Mimura T, Shimada K: Visual function and serous retinal detachment in patients with branch retinal vein occlusion and macular edema: a case series. BMC Ophthalmol. 2011, 11: 29-CrossRefPubMedPubMedCentral

20.

Kirchhoff AC, Drum ML, Zhang JX, Schlichting J, Levie J, Harrison JF, Lippold SA, Schaefer CT, Chin MH: Hypertension and hyperlipidemia management in patients treated at community health centers. J Clin Outcomes Manag. 2008, 15: 125-131.PubMedPubMedCentral

21.

Noma H, Funatsu H, Mimura T, Tatsugawa M, Shimada K, Eguchi S: Vitreous inflammatory factors and serous macular detachment in branch retinal vein occlusion. Retina. 2012, 32: 86-91.CrossRefPubMed

22.

Lerche RC, Schaudig U, Scholz F, Walter A, Richard G: Structural changes of the retina in retinal vein occlusion–imaging and quantification with optical coherence tomography. Ophthalmic Surg Lasers. 2001, 32: 272-280.PubMed

23.

Shroff D, Mehta DK, Arora R, Narula R, Chauhan D: Natural history of macular status in recent-onset branch retinal vein occlusion: an optical coherence tomography study. Int Ophthalmol. 2008, 28: 261-268.CrossRefPubMed

24.

Antonetti DA, Wolpert EB, DeMaio L, Harhaj NS, Scaduto RC: Hydrocortisone decreases retinal endothelial cell water and solute flux coincident with increased content and decreased phosphorylation of occludin. J Neurochem. 2002, 80: 667-677.CrossRefPubMed

25.

Zhang X, Bao S, Lai D, Rapkins RW, Gillies MC: Intravitreal triamcinolone acetonide inhibits breakdown of the blood-retinal barrier through differential regulation of VEGF-A and its receptors in early diabetic rat retinas. Diabetes. 2008, 57: 1026-1033.CrossRefPubMedPubMedCentral

26.

McAllister IL, Vijayasekaran S, Chen SD, Yu DY: Effect of triamcinolone acetonide on vascular endothelial growth factor and occludin levels in branch retinal vein occlusion. Am J Ophthalmol. 2009, 147: 838-846. 846 e1-2CrossRefPubMed

27.

Kurtz RM, Elner VM, Bian ZM, Strieter RM, Kunkel SL, Elner SG: Dexamethasone and cyclosporin A modulation of human retinal pigment epithelial cell monocyte chemotactic protein-1 and interleukin-8. Invest Ophthalmol Vis Sci. 1997, 38: 436-445.PubMed

28.

Sadowski T, Steinmeyer J: Effects of polysulfated glycosaminoglycan and triamcinolone acetonid on the production of proteinases and their inhibitors by IL-1alpha treated articular chondrocytes. Biochem Pharmacol. 2002, 64: 217-227.CrossRefPubMed

29.

Mizuno S, Nishiwaki A, Morita H, Miyake T, Ogura Y: Effects of periocular administration of triamcinolone acetonide on leukocyte-endothelium interactions in the ischemic retina. Invest Ophthalmol Vis Sci. 2007, 48: 2831-2836.CrossRefPubMed

30.

Miyamoto K, Khosrof S, Bursell SE, Rohan R, Murata T, Clermont AC, Aiello LP, Ogura Y, Adamis AP: Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. Proc Natl Acad Sci U S A. 1999, 96: 10836-10841.CrossRefPubMedPubMedCentral

31.

Nishijima K, Kiryu J, Tsujikawa A, Honjo M, Nonaka A, Yamashiro K, Kamizuru H, Ieki Y, Tanihara H, Honda Y, Ogura Y: Inhibitory effects of antithrombin III on interactions between blood cells and endothelial cells during retinal ischemia-reperfusion injury. Invest Ophthalmol Vis Sci. 2003, 44: 332-341.CrossRefPubMed

The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2415/12/39/prepub

Title: Comparison of the efficacy of intravitreal triamcinolone acetonide for cystoid macular edema with versus without serous retinal detachment in branch retinal vein occlusion: influence on macular sensitivity and morphology
Authors: Hidetaka Noma
Hideharu Funatsu
Tatsuya Mimura
Katsunori Shimada
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: BMC Ophthalmology / Issue 1/2012
Electronic ISSN: 1471-2415
DOI: https://doi.org/10.1186/1471-2415-12-39

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Comparison of the efficacy of intravitreal triamcinolone acetonide for cystoid macular edema with versus without serous retinal detachment in branch retinal vein occlusion: influence on macular sensitivity and morphology

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2012

Recurrent orbital schwannomas: clinical course and histopathologic correlation

Retro-mode imaging and fundus autofluorescence with scanning laser ophthalmoscope of retinal dystrophies

A comparison of the sensitivity of EQ-5D, SF-6D and TTO utility values to changes in vision and perceived visual function in patients with primary open-angle glaucoma

Aspergillus fumigatus keratitis following intracorneal ring segment implantation

Immunohistochemical localization of urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor and α2-antiplasmin in human corneal perforation: a case report

In vivo confocal microscopic and histological findings of unknown bullous keratopathy probably associated with pseudoexfoliation syndrome