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01-05-2014 | Pancreatic Tumors

Comparison of Preoperative Conference-Based Diagnosis with Histology of Cystic Tumors of the Pancreas

Authors: Marco Del Chiaro, MD, PhD, Ralf Segersvärd, MD, PhD, Raffaella Pozzi Mucelli, MD, Elena Rangelova, MD, Nikolaos Kartalis, MD, PhD, Christoph Ansorge, MD, PhD, Urban Arnelo, MD, PhD, John Blomberg, MD, PhD, Matthias Löhr, MD, PhD, Caroline Verbeke, MD, PhD

Published in: Annals of Surgical Oncology | Issue 5/2014

Abstract

Background

Diagnostic errors in the evaluation of cystic neoplasms of the pancreas (PCNs) are quite common. Few data are available regarding the impact of these errors on clinical management. The aim of this study was to determine the accuracy of a pancreatic multidisciplinary conference in diagnosing PCNs, to assess the potential risk of misdiagnosis, and to evaluate the clinical impact of these errors.

Methods

A retrospective consecutive series of patients undergoing surgery for PCNs at Karolinska University Hospital between 2004 and 2012 was analyzed.

Results

During the study period, a total of 141 patients had undergone pancreatic resection for PCN. The overall accuracy of the preoperative diagnosis was 60.9 %. The rate of concordance between preoperative diagnosis and histology was similar for asymptomatic and symptomatic lesions (62.8 vs. 59.1 %; p = NS). The rate of correct diagnosis increased over time (54.5 % in 2004–2006, 61.7 % in 2007–2012, 63.5 % in 2010–2012). Univariate analysis identified the location of the lesion (diffuse pancreatic involvement) and a mucinous nature of the lesion as factors conducive to a correct diagnosis. Reevaluation of the original indication for surgery in light of the exact diagnosis showed that a surgical procedure should not have been performed in 12 patients (8.5 %).

Conclusions

This study confirms that diagnostic errors are fairly common in the preoperative assessment of PCNs, but the errors are clinically relevant in <10 % of patients.

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Title: Comparison of Preoperative Conference-Based Diagnosis with Histology of Cystic Tumors of the Pancreas
Authors: Marco Del Chiaro, MD, PhD
Ralf Segersvärd, MD, PhD
Raffaella Pozzi Mucelli, MD
Elena Rangelova, MD
Nikolaos Kartalis, MD, PhD
Christoph Ansorge, MD, PhD
Urban Arnelo, MD, PhD
John Blomberg, MD, PhD
Matthias Löhr, MD, PhD
Caroline Verbeke, MD, PhD
Publication date: 01-05-2014
Publisher: Springer US
Published in: Annals of Surgical Oncology / Issue 5/2014
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-013-3465-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Comparison of Preoperative Conference-Based Diagnosis with Histology of Cystic Tumors of the Pancreas

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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