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European Child & Adolescent Psychiatry
Published in: European Child & Adolescent Psychiatry 1/2015

01-01-2015 | Original Contribution

Comparison of neuropsychological performances and behavioral patterns of children with attention deficit hyperactivity disorder and severe mood dysregulation

Authors: Pınar Uran, Birim Günay Kılıç

Published in: European Child & Adolescent Psychiatry | Issue 1/2015

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Abstract

We aimed to investigate the similarities and differences in neuropsychological test performance, demographic features and behavioral patterns of children and adolescents with the attention deficit hyperactivity disorder combined type (ADHD-C), and the severe mood dysregulation (SMD). Study includes 112 children: 67 with ADHD-C, 24 with SMD and 21 healthy controls. These groups were identified by using the schedule for affective disorders, and schizophrenia for the school-age children-present and lifetime version (KSADS-PL) and the K-SADS-PL-SMD Module. Conners’ Parent and Teacher Rating Scale-revised long form (CPRS-R:L and CTRS-R:L) and neuropsychological tests were administered to the research groups. ADHD-C group’s performances in Wisconsin Card Sorting Test, Trail Making Test, Stroop Test TBAG form and Controlled Oral Word Association Test were significantly poorer than the control group’s performances (p < 0.05). Performance of the SMD group was only descriptively intermediate between performances of the ADHD-C and control group. In the “Oppositional”, “Hyperactivity”, “Social Problems”, “Impulsive”, “Emotional Lability” and “Conners’ Global Index” subscales of CPRS-R:L, the average scores of the SMD group were significantly higher than the ADHD-C and control group’s average scores (p < 0.05). ADHD-C group (but not SMD) could be significantly differentiated from healthy controls with the neuropsychological tests used. SMD group could be differentiated from the ADHD-C and healthy control groups with CPRS-R:L; i.e., ADHD-C versus SMD could be differentiated at the behavioral level only.
Literature
1.
2.
Leibenluft E, Charney DS, Towbin KE, Bhangoo RK, Pine DS (2003) Defining clinical phenotypes of juvenile mania. Am J Psychiatry 160:430–437PubMedCrossRef
3.
Stringaris A, Zavos H, Leibenluft E (2012) Adolescent irritability: phenotypic associations and genetic links with depressed mood. Am J Psychiatry 169:47–54PubMedCentralPubMedCrossRef
4.
Stringaris A, Cohen P, Pine DS (2009) Adult outcomes of youth irritability: a 20-year prospective community-based study. Am J Psychiatry 166:1048–1054PubMedCentralPubMedCrossRef
5.
Brotman MA, Schmajuk M, Rich BA, Dickstein DP, Guyer AE, Costello EJ et al (2006) Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children. Biol Psychiatry 60:991–997PubMedCrossRef
6.
Copeland WE, Angold A, Costello EJ, Egger H (2013) Prevalence, comorbidity, and correlates of DSM-5 proposed disruptive mood dysregulation disorder. Am J Psychiatry 170:173–179PubMedCentralPubMedCrossRef
7.
American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders (5th edn.). American Psychiatric Publishing, Washington
8.
Jonkman LM, Kemner C, Verbaten MN, Van Engeland H, Camfferman G, Buitelaar JK, Koelega HS (2000) Attentional capacity, a probe ERP study: differences between children with attention deficit hyperactivity disorder and normal control children and effects of methylphenidate. Psychophysiology 37:334–346PubMedCrossRef
9.
Blair RJ (2010) Psychopathy, frustration, and reactive aggression: the role of ventromedial prefrontal cortex. Br J Psychol 101:383–399PubMedCrossRef
10.
Dickstein DP, Finger EC, Brotman MA, Rich BA, Pine DS, Blair JR, Leibenluft E (2010) Impaired probabilistic reversal learning in youths with mood and anxiety disorders. Psychol Med 40:1089–1100PubMedCentralPubMedCrossRef
11.
Leibenluft E (2011) Severe mood dysregulation, irritability, and the diagnostic boundaries of bipolar disorder in youths. Am J Psychiatry 168:129–142PubMedCentralPubMedCrossRef
12.
Sonuga-Barke EJS, Sergeant AJ, Nigg J, Willcutt E (2008) Executive dysfunction and delay aversion in attention deficit hyperactivity disorder: nosologic and diagnostic implications. Child Adolesc Psychiatr Clin N Am 17:367–384PubMedCrossRef
13.
Sonuga-Barke EJS, Dalen L, Remington RER (2003) Do delay aversion and inhibitory deficits make distinct contributions to pre-school AD/HD? J Am Acad Child Adolesc Psychiatry 42:1335–1342PubMedCrossRef
14.
Pennington BF, Ozonoff S (1996) Executive functions and developmental psychopathology. J Child Psychol Psychiatry 37:51–87PubMedCrossRef
15.
Willcutt EG, Doyle AE, Nigg JT, Faraone SV, Pennington BF (2005) Validity of executive function theory and attention deficit/hyperactivity disorder: a meta-analytic review. Biol Psychiatry 57:1336–1346PubMedCrossRef
16.
17.
Beesdo K, Lau JY, Guyer AE, McClure-Tone EB, Monk CS, Nelson EE, Fromm SJ, Goldwin MA, Wittchen HU, Leibenluft E, Ernst M, Pine DS (2009) Common and distinct amygdala-function perturbations in depressed vs anxious adolescents. Arch Gen Psychiatry 66:275–285PubMedCentralPubMedCrossRef
18.
19.
Nalçacı E, Kalaycıoğlu C, Güneş E, Çiçek M (2002) El tercihi anketinin geçerlik ve güvenilirliği. Turk Psikiyatri Derg 13:99–106PubMed
20.
Savaşır I, Şahin N (1995) Wechsler Çocuklar İçin Zeka Ölçegi (WISCR) El Kitabı. Türk Psikologlar Dernegi Yayınları, Ankara
21.
Gökler B, Ünal F, Pehlivantürk B, Kültür EÇ, Akdemir D, Taner Y (2004) Reliability and validity of Schedule for Affective Disorders and Schizophrenia for School Age Children-Present and Lifetime Version. Turk J Child Adoles Mental Health 11:109–116
22.
Çöp E (2009) DEHB’de ADD Yaygınlığı. Eşlik Eden Hastalıklar ve Bilişsel Özellikleri, Yayınlanmamış Tıpta Uzmanlık Tezi Hacettepe Üniversitesi, Ankara
23.
Conners CK, Sitarenios G, Parker JD, Epstein JN (1998) Revision and restandardization of the Conners parent rating scale (CPRS-R): factor structure, reliability, and criterion validity. J Abnorm Child Psychol 26:257–268PubMedCrossRef
24.
Conners CK, Sitarenios G, Parker JD, Epstein JN (1998) Revision and restandardization of the Conners teacher rating scale (CTRS-R): factor structure, reliability, and criterion validity. J Abnorm Child Psychol 26:279–291PubMedCrossRef
25.
Kaner S, Büyüköztürk Ş, İşeri E, Ak A, Özaydın L (2011) Conners’ parent rating scale long form-revised: factor structure, reliability and validity studies. Turk J Child Adoles Mental Health 18:45–58
26.
Spreen OE, Strauss A (1998) Compendium of neuropsychological tests: administration, norms, and commentary. Oxford University Press, New York
27.
Berg EA (1948) A simple objective technique for measuring flexibility in thinking. J Gen Psychol 39:15–22PubMedCrossRef
28.
Karakaş S, Doğutepe Dinçer E (eds) (2011) Bilnot Bataryası El Kitabı. Bilnot-Çocuk Cilt-I-II, Nobel Tıp Kitabevleri, İstanbul
29.
Stroop JR (1935) Studies of interference in serial verbal reactions. J Exp Psychol 18:643–662CrossRef
30.
Mitrushina M, Bone KB, Razani J, D’Elia LF (2005) Handbook of normative data for neuropsychological assessment, 2nd edn. Oxford University Pres, New York
31.
Grodzinsky GM, Barkley RA (1999) Predictive power of frontal lobe tests in the diagnosis of attention deficit hyperactivity disorder. Clin Neuropsychol 13:12–21PubMedCrossRef
32.
Sergeant JA, Geurts H, Oosterlaan J (2002) How specific is a deficit of executive functioning for attention deficit/hyperactivity disorder? Behavioral Brain Res 130:3–28CrossRef
33.
Tripp G, Ryan J, Peace K (2002) Neuropsychological functioning in children with DSM-IV combined type attention deficit hyperactivity disorder. Aust N Z J Psychiatry 36:771–779PubMedCrossRef
34.
Houghton S, Douglas G, West J, Whiting K, Wall M, Langsford S, Powell L, Carroll A (1999) Differential patterns of executive function in children with attention-deficit hyperactivity disorder according to gender and subtype. J Child Neurol 14:801–805PubMedCrossRef
35.
Weber P, Lütschg J, Fahnenstich H (2005) Cerebral hemodynamic changes in response to an executive function task in children with attention-deficit hyperactivity disorder measured by near-infrared spectroscopy. J Dev Behav Pediatr 26:105–111PubMedCrossRef
36.
Chiang M, Gau SS (2008) Validation of attention-deficit-hyperactivity disorder subtypes among Taiwanese children using neuropsychological functioning. Aust NZJ Psychiatry 42:526–535CrossRef
37.
Hale JB, Reddy LA, Decker SL, Thompson R, Henzel J, Teodori A, Forrest E, Eusebio E, Denckla MB (2009) Development and validation of an attention-deficit/hyperactivity disorder (ADHD) executive function and behavior rating screening battery. J Clin Exp Neuropsychol 31:897–912PubMedCrossRef
38.
Qian Y, Shuai L, Cao Q, Chan RC, Wang Y (2010) Do executive function deficits differentiate between children with attention deficit hyperactivity disorder (ADHD) and ADHD comorbid with oppositional defiant disorder? A cross-cultural study using performance-based tests and the behavior rating. İnventory of executive function. Clin Neuropsychol 24:793–810PubMedCrossRef
39.
Wakschlag LS, Choi SW, Carter AS, Hullsiek H, Burns J, McCarthy K, Leibenluft E, Briggs-Gowan MJ (2012) Defining the developmental parameters of temper loss in early childhood: implications for developmental psychopathology. J Child Psychol Psychiatry 53:1099–1108PubMedCentralPubMedCrossRef
40.
Biederman J, Petty CR, Day H, Goldin RL, Spencer T, Faraone SV, Surman CB, Wozniak J (2012) Severity of the aggression/anxiety-depression/attention child behavior checklist profile discriminates between different levels of deficits in emotional regulation in youth with attention-deficit hyperactivity disorder. J Dev Behav Pediatr 33:236–243PubMedCentralPubMedCrossRef
41.
Ochsner KN (2008) The social-emotional processing stream: five core constructs and their translational potential for schizophrenia and beyond. Biol Psychiatry 64:48–61PubMedCentralPubMedCrossRef
42.
Happaney K et al (2004) Development of orbitofrontal function: current themes and future directions. Brain Cogn 55:1–10PubMedCrossRef
43.
Metadata
Title
Comparison of neuropsychological performances and behavioral patterns of children with attention deficit hyperactivity disorder and severe mood dysregulation
Authors
Pınar Uran
Birim Günay Kılıç
Publication date
01-01-2015
Publisher
Springer Berlin Heidelberg
Published in
European Child & Adolescent Psychiatry / Issue 1/2015
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI
https://doi.org/10.1007/s00787-014-0529-8

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