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Published in: Neurosurgical Review 1/2008

01-01-2008 | Original Article

Comparison of lateral and superior walls of the pituitary fossa with clinical emphasis on pituitary adenoma extension: cadaveric-anatomic study

Authors: Erim Kursat, Selcuk Yilmazlar, Sibel Aker, Kaya Aksoy, Hakan Oygucu

Published in: Neurosurgical Review | Issue 1/2008

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Abstract

Pituitary adenomas extend to the suprasellar region via diaphragmal passage and extend to the cavernous sinus via the medial wall (MW). Better understanding of the dynamics of suprasellar and parasellar extension of sellar region pathologies requires microanatomical comparison of diaphragma sellae (DS) and the MW of the cavernous sinus. This study provides the first detailed quantitative assessment between DS and MW of the cavernous sinus. Microanatomical details and histopathological examinations of the DS and MWs of the cavernous sinus were studied in sphenoid block samples obtained from adult cadavers, and the thicknesses of the DS and the MW of the cavernous sinus were measured. Mean thickness of the DS was 216.73 ± 51.26 μm in the center and 367.33 ± 133.66 μm in the periphery. Mean thickness of the lower third of the MW was 161.53 ± 53.86 μm and that of the upper third was 278.46 ± 162.79 μm. Difference between the thicknesses of the upper and lower thirds was significant (P < 0.001). When the central thickness of the DS and lower third of the MW were compared, a significant difference was found (P < 0.01). Our measurements suggest that when the DS is thick and the stalk opening is complete, the thickness of the lower third of the medial wall could be the major determinant of parasellar extension.
Literature
1.
go back to reference Ahmadi J, North CM, Segall HD, Zee CS, Weiss MH (1986) Cavernous sinus invasion by pituitary adenomas. AJR Am J Roentgenol 146:257–262PubMed Ahmadi J, North CM, Segall HD, Zee CS, Weiss MH (1986) Cavernous sinus invasion by pituitary adenomas. AJR Am J Roentgenol 146:257–262PubMed
2.
go back to reference Bergland RM, Ray BS, Torack RM (1968) Anatomical variations in the pituitary gland and adjacent structures in 225 human autopsy cases. J Neurosurg 28:93–99PubMedCrossRef Bergland RM, Ray BS, Torack RM (1968) Anatomical variations in the pituitary gland and adjacent structures in 225 human autopsy cases. J Neurosurg 28:93–99PubMedCrossRef
3.
go back to reference Chi JG, Lee MH (1980) Anatomical observations of the development of the pituitary capsule. J Neurosurg 52:667–670PubMed Chi JG, Lee MH (1980) Anatomical observations of the development of the pituitary capsule. J Neurosurg 52:667–670PubMed
4.
go back to reference Cottier JP, Destrieux C, Brunereau L, Bertrand P, Moreau L, Jan M, Herbreteau D (2000) Cavernous sinus invasion by pituitary adenoma: MR imaging. Radiology 215:463–469PubMed Cottier JP, Destrieux C, Brunereau L, Bertrand P, Moreau L, Jan M, Herbreteau D (2000) Cavernous sinus invasion by pituitary adenoma: MR imaging. Radiology 215:463–469PubMed
5.
go back to reference Daniels DL, Pojunas KW, Kilgore DP, Pech P, Meyer GA, Williams AL, Haughton VM (1986) MR of the diaphragma sellae. AJNR Am J Neuroradiol 7:765–769PubMed Daniels DL, Pojunas KW, Kilgore DP, Pech P, Meyer GA, Williams AL, Haughton VM (1986) MR of the diaphragma sellae. AJNR Am J Neuroradiol 7:765–769PubMed
6.
go back to reference Destrieux C, Kakou MK, Velut S, Lefrancq T, Jan M (1998) Microanatomy of the hypophyseal fossa boundaries. J Neurosurg 88:743–752PubMed Destrieux C, Kakou MK, Velut S, Lefrancq T, Jan M (1998) Microanatomy of the hypophyseal fossa boundaries. J Neurosurg 88:743–752PubMed
7.
go back to reference Dietemann JL, Kehrli P, Maillot C, Diniz R, Reis M Jr., Neugroschl C, Vinclair L (1998) Is there a dural wall between the cavernous sinus and the pituitary fossa? Anatomical and MRI findings. Neuroradiology 40:627–630PubMedCrossRef Dietemann JL, Kehrli P, Maillot C, Diniz R, Reis M Jr., Neugroschl C, Vinclair L (1998) Is there a dural wall between the cavernous sinus and the pituitary fossa? Anatomical and MRI findings. Neuroradiology 40:627–630PubMedCrossRef
8.
go back to reference Elster AD (1993) Modern imaging of the pituitary. Radiology 187:1–14PubMed Elster AD (1993) Modern imaging of the pituitary. Radiology 187:1–14PubMed
9.
go back to reference Fahlbusch R, Buchfelder M (1988) Transsphenoidal surgery of parasellar pituitary adenomas. Acta Neurochir (Wien) 92:93–99CrossRef Fahlbusch R, Buchfelder M (1988) Transsphenoidal surgery of parasellar pituitary adenomas. Acta Neurochir (Wien) 92:93–99CrossRef
10.
go back to reference Ferreri AJ, Garrido SA, Markarian MG, Yanez A (1992) Relationship between the development of diaphragma sellae and the morphology of the sella turcica and its content. Surg Radiol Anat 14:233–239PubMedCrossRef Ferreri AJ, Garrido SA, Markarian MG, Yanez A (1992) Relationship between the development of diaphragma sellae and the morphology of the sella turcica and its content. Surg Radiol Anat 14:233–239PubMedCrossRef
11.
go back to reference Garibi J, Pomposo I, Villar G, Gaztambide S (2002) Giant pituitary adenomas: clinical characteristics and surgical results. Br J Neurosurg 16:133–139PubMedCrossRef Garibi J, Pomposo I, Villar G, Gaztambide S (2002) Giant pituitary adenomas: clinical characteristics and surgical results. Br J Neurosurg 16:133–139PubMedCrossRef
12.
go back to reference Harris FS, Rhoton AL (1976) Anatomy of the cavernous sinus. A microsurgical study. J Neurosurg 45:169–180PubMed Harris FS, Rhoton AL (1976) Anatomy of the cavernous sinus. A microsurgical study. J Neurosurg 45:169–180PubMed
13.
go back to reference Kaufman B (1968) The “empty” sella turcica—a manifestation of the intrasellar subarachnoid space. Radiology 90:931–941PubMed Kaufman B (1968) The “empty” sella turcica—a manifestation of the intrasellar subarachnoid space. Radiology 90:931–941PubMed
14.
go back to reference Kawase T, van Loveren H, Keller JT, Tew JM (1996) Meningeal architecture of the cavernous sinus: clinical and surgical implications. Neurosurgery 39:527–534PubMedCrossRef Kawase T, van Loveren H, Keller JT, Tew JM (1996) Meningeal architecture of the cavernous sinus: clinical and surgical implications. Neurosurgery 39:527–534PubMedCrossRef
15.
go back to reference Kehrli P, Maillot C, Wolff MJ (1997) Anatomy and embryology of the trigeminal nerve and its branches in the parasellar area. Neurol Res 19:57–65PubMed Kehrli P, Maillot C, Wolff MJ (1997) Anatomy and embryology of the trigeminal nerve and its branches in the parasellar area. Neurol Res 19:57–65PubMed
16.
go back to reference Kim JM, Romano A, Sanan A, van Loveren HR, Keller JT (2000) Microsurgical anatomic features and nomenclature of the paraclinoid region. Neurosurgery 46:670–680PubMedCrossRef Kim JM, Romano A, Sanan A, van Loveren HR, Keller JT (2000) Microsurgical anatomic features and nomenclature of the paraclinoid region. Neurosurgery 46:670–680PubMedCrossRef
17.
go back to reference Knosp E, Steiner E, Kitz K, Matula C (1993) Pituitary adenomas with invasion of the cavernous sinus space: a magnetic resonance imaging classification compared with surgical findings. Neurosurgery 33:610–617PubMedCrossRef Knosp E, Steiner E, Kitz K, Matula C (1993) Pituitary adenomas with invasion of the cavernous sinus space: a magnetic resonance imaging classification compared with surgical findings. Neurosurgery 33:610–617PubMedCrossRef
18.
go back to reference Krisht AF KP (2003) Microsurgical anatomy of the cavernous sinus. Tech Neurosurg 8:199–203CrossRef Krisht AF KP (2003) Microsurgical anatomy of the cavernous sinus. Tech Neurosurg 8:199–203CrossRef
19.
go back to reference Krisht A, Barnett DW, Barrow DL, Bonner G (1994) The blood supply of the intracavernous cranial nerves: an anatomic study. Neurosurgery 34:275–279PubMedCrossRef Krisht A, Barnett DW, Barrow DL, Bonner G (1994) The blood supply of the intracavernous cranial nerves: an anatomic study. Neurosurgery 34:275–279PubMedCrossRef
20.
go back to reference Lee KF, Parke W, Lin SR, Choi HY, Schatz NJ (1978) The vasculature of the diaphragma sellae. A postmortem injection study. Neuroradiology 16:281–283PubMedCrossRef Lee KF, Parke W, Lin SR, Choi HY, Schatz NJ (1978) The vasculature of the diaphragma sellae. A postmortem injection study. Neuroradiology 16:281–283PubMedCrossRef
21.
go back to reference Majos C, Coll S, Aguilera C, Acebes JJ, Pons LC (1998) Imaging of giant pituitary adenomas. Neuroradiology 40:651–655PubMedCrossRef Majos C, Coll S, Aguilera C, Acebes JJ, Pons LC (1998) Imaging of giant pituitary adenomas. Neuroradiology 40:651–655PubMedCrossRef
22.
go back to reference Marinkovic S, Gibo H, Vucevic R, Petrovic P (2001) Anatomy of the cavernous sinus region. J Clin Neurosci 8(Suppl 1):78–81PubMedCrossRef Marinkovic S, Gibo H, Vucevic R, Petrovic P (2001) Anatomy of the cavernous sinus region. J Clin Neurosci 8(Suppl 1):78–81PubMedCrossRef
23.
go back to reference Nomura M, Tachibana O, Yamashima T, Yamashita J, Suzuki M (2002) MRI evaluation of the diaphragmal opening: using MRI parallel to the transsphenoidal surgical approach. J Clin Neurosci 9:175–177PubMedCrossRef Nomura M, Tachibana O, Yamashima T, Yamashita J, Suzuki M (2002) MRI evaluation of the diaphragmal opening: using MRI parallel to the transsphenoidal surgical approach. J Clin Neurosci 9:175–177PubMedCrossRef
24.
go back to reference Ouaknine GE, Hardy J (1987) Microsurgical anatomy of the pituitary gland and the sellar region. 2. The bony structures. Am Surg 53:291–297PubMed Ouaknine GE, Hardy J (1987) Microsurgical anatomy of the pituitary gland and the sellar region. 2. The bony structures. Am Surg 53:291–297PubMed
25.
go back to reference Peker S, Kurtkaya-Yapicier O, Kilic T, Pamir MN (2005) Microsurgical anatomy of the lateral walls of the pituitary fossa. Acta Neurochir (Wien) 147:641–648CrossRef Peker S, Kurtkaya-Yapicier O, Kilic T, Pamir MN (2005) Microsurgical anatomy of the lateral walls of the pituitary fossa. Acta Neurochir (Wien) 147:641–648CrossRef
26.
27.
go back to reference Renn WH, Rhoton AL Jr (1975) Microsurgical anatomy of the sellar region. J Neurosurg 43:288–298PubMed Renn WH, Rhoton AL Jr (1975) Microsurgical anatomy of the sellar region. J Neurosurg 43:288–298PubMed
29.
go back to reference Sage MR, Blumbergs PC (2000) Primary empty sella turcica: a radiological-anatomical correlation. Australas Radiol 44:341–348PubMedCrossRef Sage MR, Blumbergs PC (2000) Primary empty sella turcica: a radiological-anatomical correlation. Australas Radiol 44:341–348PubMedCrossRef
30.
go back to reference Sage MR, Blumbergs PC, Fowler GW (1982) The diaphragma sellae: its relationship to normal sellar variations in frontal radiographic projections. Radiology 145:699–701PubMed Sage MR, Blumbergs PC, Fowler GW (1982) The diaphragma sellae: its relationship to normal sellar variations in frontal radiographic projections. Radiology 145:699–701PubMed
31.
go back to reference Sage MR, Blumbergs PC, Mulligan BP, Fowler GW (1982) The diaphragma sellae: its relationship to the configuration of the pituitary gland. Radiology 145:703–708PubMed Sage MR, Blumbergs PC, Mulligan BP, Fowler GW (1982) The diaphragma sellae: its relationship to the configuration of the pituitary gland. Radiology 145:703–708PubMed
32.
go back to reference Sekhar LN, Burgess J, Akin O (1987) Anatomical study of the cavernous sinus emphasizing operative approaches and related vascular and neural reconstruction. Neurosurgery 21:806–816PubMedCrossRef Sekhar LN, Burgess J, Akin O (1987) Anatomical study of the cavernous sinus emphasizing operative approaches and related vascular and neural reconstruction. Neurosurgery 21:806–816PubMedCrossRef
33.
go back to reference Swanson MW (1990) Neuroanatomy of the cavernous sinus and clinical correlations. Optom Vis Sci 67:891–897PubMed Swanson MW (1990) Neuroanatomy of the cavernous sinus and clinical correlations. Optom Vis Sci 67:891–897PubMed
34.
go back to reference Umansky F, Nathan H (1982) The lateral wall of the cavernous sinus. With special reference to the nerves related to it. J Neurosurg 56:228–234PubMed Umansky F, Nathan H (1982) The lateral wall of the cavernous sinus. With special reference to the nerves related to it. J Neurosurg 56:228–234PubMed
35.
go back to reference Umansky F, Valarezo A, Elidan J (1994) The superior wall of the cavernous sinus: a microanatomical study. J Neurosurg 81:914–920PubMed Umansky F, Valarezo A, Elidan J (1994) The superior wall of the cavernous sinus: a microanatomical study. J Neurosurg 81:914–920PubMed
36.
go back to reference Weninger WJ, Muller GB (1999) The parasellar region of human infants: cavernous sinus topography and surgical approaches. J Neurosurg 90:484–490PubMed Weninger WJ, Muller GB (1999) The parasellar region of human infants: cavernous sinus topography and surgical approaches. J Neurosurg 90:484–490PubMed
37.
go back to reference Weninger WJ, Pramhas D (2000) Compartments of the adult parasellar region. J Anat 197(Pt 4):681–686PubMedCrossRef Weninger WJ, Pramhas D (2000) Compartments of the adult parasellar region. J Anat 197(Pt 4):681–686PubMedCrossRef
38.
go back to reference Williams PL (1995) Gray’s anatomy, 38rd edn. Churchill Livingstone, Edinburg, p 1211 Williams PL (1995) Gray’s anatomy, 38rd edn. Churchill Livingstone, Edinburg, p 1211
39.
go back to reference Wolpert SM, Molitch ME, Goldman JA, Wood JB (1984) Size, shape, and appearance of the normal female pituitary gland. AJR Am J Roentgenol 143:377–381PubMed Wolpert SM, Molitch ME, Goldman JA, Wood JB (1984) Size, shape, and appearance of the normal female pituitary gland. AJR Am J Roentgenol 143:377–381PubMed
40.
go back to reference Yasuda A, Campero A, Martins C, Rhoton AL Jr, Ribas GC (2004) The medial wall of the cavernous sinus: microsurgical anatomy. Neurosurgery 55:179–189PubMedCrossRef Yasuda A, Campero A, Martins C, Rhoton AL Jr, Ribas GC (2004) The medial wall of the cavernous sinus: microsurgical anatomy. Neurosurgery 55:179–189PubMedCrossRef
41.
go back to reference Yilmazlar S, Kocaeli H, Aydiner F, Korfali E (2005) Medial portion of the cavernous sinus: quantitative analysis of the medial wall. Clin Anat 18:416–422PubMedCrossRef Yilmazlar S, Kocaeli H, Aydiner F, Korfali E (2005) Medial portion of the cavernous sinus: quantitative analysis of the medial wall. Clin Anat 18:416–422PubMedCrossRef
42.
go back to reference Yokoyama S, Hirano H, Moroki K, Goto M, Imamura S, Kuratsu JI (2001) Are nonfunctioning pituitary adenomas extending into the cavernous sinus aggressive and/or invasive? Neurosurgery 49:857–862PubMedCrossRef Yokoyama S, Hirano H, Moroki K, Goto M, Imamura S, Kuratsu JI (2001) Are nonfunctioning pituitary adenomas extending into the cavernous sinus aggressive and/or invasive? Neurosurgery 49:857–862PubMedCrossRef
Metadata
Title
Comparison of lateral and superior walls of the pituitary fossa with clinical emphasis on pituitary adenoma extension: cadaveric-anatomic study
Authors
Erim Kursat
Selcuk Yilmazlar
Sibel Aker
Kaya Aksoy
Hakan Oygucu
Publication date
01-01-2008
Publisher
Springer-Verlag
Published in
Neurosurgical Review / Issue 1/2008
Print ISSN: 0344-5607
Electronic ISSN: 1437-2320
DOI
https://doi.org/10.1007/s10143-007-0112-6

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