Skip to main content
Top
Published in: Diseases of the Colon & Rectum 4/2008

01-04-2008 | Original Contribution

Comparison of Laparoscopic vs. Open Access Surgery in Patients with Rectal Cancer: A Prospective Analysis

Authors: Michael A. Ströhlein, M.D., Klaus-Uwe Grützner, M.D., Karl-Walter Jauch, M.D., Markus M. Heiss, M.D.

Published in: Diseases of the Colon & Rectum | Issue 4/2008

Login to get access

Abstract

Purpose

Laparoscopic surgery of colon cancer has been accepted to be oncologically adequate compared with open resection. However, the situation in rectal cancer remains unclear, because anatomy and complex surgical procedures might specifically influence the long-term outcome. This study was designed to analyze perioperative and long-term outcome of patients with rectal cancer after laparoscopic vs. open access surgery.

Methods

A total of 389 patients (1998–2005) were prospectively analyzed; 114 patients had laparoscopic beginning, and 25 patients had conversion and were separately analyzed. Eighty-nine patients remained in the laparoscopic group and 275 had open access surgery.

Results

Both groups were comparable regarding age, gender, tumor localization, stage, and complications. Differences were found in harvested lymph nodes (laparoscopic 13.5/open access 16.9; P = 0.001) and hospitalization (15.1/18.7 days; P = 0.037). Local recurrence rate and metachronous metastasis were comparable. In patients with deep anterior resection with total mesenteric excision, favorable long-term survival in the laparoscopic group was found (P = 0.035, log-rank).

Conclusions

Minimally invasive surgery is equivalent in the treatment of rectal cancer and shows advantages of shorter hospitalization and faster recovery. Especially in patients with low rectal cancer, minimally invasive surgery with exact preparation of the total mesenteric excision seems to be favorable compared with open access surgery.
Literature
1.
go back to reference Fitzgibbons RJ Jr, Puri V. Laparoscopic inguinal hernia repair. Am Surg 2006;72:197–206.PubMed Fitzgibbons RJ Jr, Puri V. Laparoscopic inguinal hernia repair. Am Surg 2006;72:197–206.PubMed
2.
go back to reference Shamiyeh A, Wayand W. Current status of laparoscopic therapy of cholecystolithiasis and common bile duct stones. Dig Dis 2005;23:119–26.PubMedCrossRef Shamiyeh A, Wayand W. Current status of laparoscopic therapy of cholecystolithiasis and common bile duct stones. Dig Dis 2005;23:119–26.PubMedCrossRef
3.
go back to reference Patel NA, Bergamaschi R. Laparoscopy for diverticulitis. Semin Laparosc Surg 2003;10:177–83.PubMed Patel NA, Bergamaschi R. Laparoscopy for diverticulitis. Semin Laparosc Surg 2003;10:177–83.PubMed
4.
5.
go back to reference Guillou PJ, Quirke P, Thorpe H, et al. Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet 2005;365:1718–26.PubMedCrossRef Guillou PJ, Quirke P, Thorpe H, et al. Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet 2005;365:1718–26.PubMedCrossRef
6.
go back to reference Veldkamp R, Kuhry E, Hop WC, et al. Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial. Lancet Oncol 2005;6:477–84.PubMedCrossRef Veldkamp R, Kuhry E, Hop WC, et al. Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial. Lancet Oncol 2005;6:477–84.PubMedCrossRef
7.
go back to reference Clinical Outcomes of Surgical Therapy Study Group. A comparison of laparoscopically assisted and open colectomy for colon cancer. N Engl J Med 2004;350:2050–9.CrossRef Clinical Outcomes of Surgical Therapy Study Group. A comparison of laparoscopically assisted and open colectomy for colon cancer. N Engl J Med 2004;350:2050–9.CrossRef
8.
go back to reference Marescaux J, Rubino F, Leroy J. Laparoscopic total mesorectal excision for rectal cancer surgery. Dig Dis 2005;23:135–41.PubMedCrossRef Marescaux J, Rubino F, Leroy J. Laparoscopic total mesorectal excision for rectal cancer surgery. Dig Dis 2005;23:135–41.PubMedCrossRef
9.
go back to reference Anthuber M, Fuerst A, Elser F, Berger R, Jauch KW. Outcome of laparoscopic surgery for rectal cancer in 101 patients. Dis Colon Rectum 2003;46:1047–53.PubMedCrossRef Anthuber M, Fuerst A, Elser F, Berger R, Jauch KW. Outcome of laparoscopic surgery for rectal cancer in 101 patients. Dis Colon Rectum 2003;46:1047–53.PubMedCrossRef
10.
go back to reference Wichmann MW, Huttl TP, Winter H, et al. Immunological effects of laparoscopic vs open colorectal surgery: a prospective clinical study. Arch Surg 2005;140:692–7.PubMedCrossRef Wichmann MW, Huttl TP, Winter H, et al. Immunological effects of laparoscopic vs open colorectal surgery: a prospective clinical study. Arch Surg 2005;140:692–7.PubMedCrossRef
11.
go back to reference Whelan RL, Franklin M, Holubar SD, et al. Postoperative cell mediated immune response is better preserved after laparoscopic vs. open colorectal resection in humans. Surg Endosc 2003;17:972–8.PubMedCrossRef Whelan RL, Franklin M, Holubar SD, et al. Postoperative cell mediated immune response is better preserved after laparoscopic vs. open colorectal resection in humans. Surg Endosc 2003;17:972–8.PubMedCrossRef
12.
go back to reference Leung KL, Kwok SP, Lam SC, et al. Laparoscopic resection of rectosigmoid carcinoma: prospective randomised trial. Lancet 2004;363:1187–92.PubMedCrossRef Leung KL, Kwok SP, Lam SC, et al. Laparoscopic resection of rectosigmoid carcinoma: prospective randomised trial. Lancet 2004;363:1187–92.PubMedCrossRef
13.
go back to reference Breukink SO, Grond AJ, Pierie JP, Hoff C, Wiggers T, Meijerink WJ. Laparoscopic vs. open total mesorectal excision for rectal cancer: an evaluation of the mesorectum’s macroscopic quality. Surg Endosc 2005;19:307–10.PubMedCrossRef Breukink SO, Grond AJ, Pierie JP, Hoff C, Wiggers T, Meijerink WJ. Laparoscopic vs. open total mesorectal excision for rectal cancer: an evaluation of the mesorectum’s macroscopic quality. Surg Endosc 2005;19:307–10.PubMedCrossRef
14.
go back to reference Bretagnol F, Lelong B, Laurent C, et al. The oncological safety of laparoscopic total mesorectal excision with sphincter preservation for rectal carcinoma. Surg Endosc 2005;19:892–6.PubMedCrossRef Bretagnol F, Lelong B, Laurent C, et al. The oncological safety of laparoscopic total mesorectal excision with sphincter preservation for rectal carcinoma. Surg Endosc 2005;19:892–6.PubMedCrossRef
15.
go back to reference Leroy J, Jamali F, Forbes L, et al. Laparoscopic total mesorectal excision (TME) for rectal cancer surgery: long-term outcomes. Surg Endosc 2004;18:281–9.PubMedCrossRef Leroy J, Jamali F, Forbes L, et al. Laparoscopic total mesorectal excision (TME) for rectal cancer surgery: long-term outcomes. Surg Endosc 2004;18:281–9.PubMedCrossRef
16.
go back to reference Breukink S, Pierie J, Wiggers T. Laparoscopic versus open total mesorectal excision for rectal cancer. Cochrane Database Syst Rev 2006;CD005200. Breukink S, Pierie J, Wiggers T. Laparoscopic versus open total mesorectal excision for rectal cancer. Cochrane Database Syst Rev 2006;CD005200.
17.
go back to reference Lacy AM, Garcia-Valdecasas JC, Delgado S, et al. Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial. Lancet 2002;359:2224–9.PubMedCrossRef Lacy AM, Garcia-Valdecasas JC, Delgado S, et al. Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial. Lancet 2002;359:2224–9.PubMedCrossRef
18.
go back to reference Morino M, Parini U, Giraudo G, Salval M, Brachet CR, Garrone C. Laparoscopic total mesorectal excision: a consecutive series of 100 patients. Ann Surg 2003;237:335–42.PubMedCrossRef Morino M, Parini U, Giraudo G, Salval M, Brachet CR, Garrone C. Laparoscopic total mesorectal excision: a consecutive series of 100 patients. Ann Surg 2003;237:335–42.PubMedCrossRef
19.
go back to reference Feliciotti F, Guerrieri M, Paganini AM, et al. Long-term results of laparoscopic versus open resections for rectal cancer for 124 unselected patients. Surg Endosc 2003;17:1530–5.PubMedCrossRef Feliciotti F, Guerrieri M, Paganini AM, et al. Long-term results of laparoscopic versus open resections for rectal cancer for 124 unselected patients. Surg Endosc 2003;17:1530–5.PubMedCrossRef
20.
go back to reference Karanjia ND, Corder AP, Bearn P, Heald RJ. Leakage from stapled low anastomosis after total mesorectal excision for carcinoma of the rectum. Br J Surg 1994;81:1224–6.PubMedCrossRef Karanjia ND, Corder AP, Bearn P, Heald RJ. Leakage from stapled low anastomosis after total mesorectal excision for carcinoma of the rectum. Br J Surg 1994;81:1224–6.PubMedCrossRef
21.
go back to reference Gervaz P, Pikarsky A, Utech M, et al. Converted laparoscopic colorectal surgery. Surg Endosc 2001;15:827–32.PubMedCrossRef Gervaz P, Pikarsky A, Utech M, et al. Converted laparoscopic colorectal surgery. Surg Endosc 2001;15:827–32.PubMedCrossRef
22.
go back to reference Gonzalez R, Smith CD, Mason E, et al. Consequences of conversion in laparoscopic colorectal surgery. Dis Colon Rectum 2006;49:197–204.PubMedCrossRef Gonzalez R, Smith CD, Mason E, et al. Consequences of conversion in laparoscopic colorectal surgery. Dis Colon Rectum 2006;49:197–204.PubMedCrossRef
23.
go back to reference Tekkis PP, Senagore AJ, Delaney CP. Conversion rates in laparoscopic colorectal surgery: a predictive model with, 1253 patients. Surg Endosc 2005;19:47–54.PubMedCrossRef Tekkis PP, Senagore AJ, Delaney CP. Conversion rates in laparoscopic colorectal surgery: a predictive model with, 1253 patients. Surg Endosc 2005;19:47–54.PubMedCrossRef
Metadata
Title
Comparison of Laparoscopic vs. Open Access Surgery in Patients with Rectal Cancer: A Prospective Analysis
Authors
Michael A. Ströhlein, M.D.
Klaus-Uwe Grützner, M.D.
Karl-Walter Jauch, M.D.
Markus M. Heiss, M.D.
Publication date
01-04-2008
Publisher
Springer-Verlag
Published in
Diseases of the Colon & Rectum / Issue 4/2008
Print ISSN: 0012-3706
Electronic ISSN: 1530-0358
DOI
https://doi.org/10.1007/s10350-007-9178-z

Other articles of this Issue 4/2008

Diseases of the Colon & Rectum 4/2008 Go to the issue