Skip to main content
Top
Published in: Child's Nervous System 4/2016

01-04-2016 | Original Paper

Comparison of heart rate changes with ictal tachycardia seizures in adults and children

Authors: Wei Chen, Xi-Ting Zhang, Chang-Li Guo, Shu-Jing Zhang, Xian-Wei Zeng, Fan-Gang Meng

Published in: Child's Nervous System | Issue 4/2016

Login to get access

Abstract

Purpose

Lower heart rate variability (HRV) is known to make patients more susceptible to tachycardia and possibly sudden unexpected death in epilepsy (SUDEP). The heart rate (HR) at which tachycardia is present may vary by age. To date, no study has been done comparing adult and child seizures at different time points. The purpose of this study was to compare the frequency of HR changes with ictal tachycardia (IT) seizures at different time points in adults versus children.

Methods

We retrospectively assessed the changes in the HR of 99 IT seizures in children and 96 IT seizures in adults. The difference between adults and children in gender, hemispheric lateralization or sleep/wakefulness, or seizure type on the HR changes and the difference between children and adults during 10 s preictal, ictal onset, and ictal and 60 s postictal were separately assessed.

Results

The HR difference and maximum HR increase with aging in children. The seizure duration in adults lasted longer as compared with that in children. There are higher HR at different points and HR difference at 10 s preictal as compared to baseline in children.

Conclusions

The study illustrates that age and duration were respectively related to HR differences distinguishing children from adults. There may be an age-related effect of HR changes associated with seizures, with higher HR at different times and HR difference at 10 s before seizure onset as compared to baseline in children, which might explain that children are more likely to predict epileptic seizures than adults, contributing to subclinical seizures and treatment efficiency in refractory patients.
Literature
1.
2.
go back to reference Jansen K, Vandeput S, Milosevic M, Ceulemans B, Van Huffel S, Brown L, Penders J, Lagae L (2011) Autonomic effects of refractory epilepsy on heart rate variability in children: influence of intermittent vagus nerve stimulation. Dev Med Child Neurol 53:1143–1149CrossRefPubMed Jansen K, Vandeput S, Milosevic M, Ceulemans B, Van Huffel S, Brown L, Penders J, Lagae L (2011) Autonomic effects of refractory epilepsy on heart rate variability in children: influence of intermittent vagus nerve stimulation. Dev Med Child Neurol 53:1143–1149CrossRefPubMed
3.
go back to reference Tomson T, Ericson M, Ihrman C, Lindblad LE (1998) Heart rate variability in patients with epilepsy. Epilepsy Res 30:77–83CrossRefPubMed Tomson T, Ericson M, Ihrman C, Lindblad LE (1998) Heart rate variability in patients with epilepsy. Epilepsy Res 30:77–83CrossRefPubMed
4.
go back to reference Harnod T, Yang CC, Hsin YL, Shieh KR, Wang PJ, Kuo TB (2008) Heart rate variability in children with refractory generalized epilepsy. Seizure 17:297–301CrossRefPubMed Harnod T, Yang CC, Hsin YL, Shieh KR, Wang PJ, Kuo TB (2008) Heart rate variability in children with refractory generalized epilepsy. Seizure 17:297–301CrossRefPubMed
5.
go back to reference Pfeifer MA, Weinberg CR, Cook D, Best JD, Reenan A, Halter JB (1983) Differential changes of autonomic nervous system function with age in man. Am J Med 75:249–258CrossRefPubMed Pfeifer MA, Weinberg CR, Cook D, Best JD, Reenan A, Halter JB (1983) Differential changes of autonomic nervous system function with age in man. Am J Med 75:249–258CrossRefPubMed
6.
go back to reference Eggleston KS, Olin BD, Fisher RS (2014) Ictal tachycardia: the head-heart connection. Seizure 23:496–505CrossRefPubMed Eggleston KS, Olin BD, Fisher RS (2014) Ictal tachycardia: the head-heart connection. Seizure 23:496–505CrossRefPubMed
7.
go back to reference Pavlova M, Singh K, Abdennadher M, Katz ES, Dworetzky BA, White DP, Llewellyn N, Kothare SV (2013) Comparison of cardiorespiratory and EEG abnormalities with seizures in adults and children. Epilepsy Behav 29:537–541CrossRefPubMed Pavlova M, Singh K, Abdennadher M, Katz ES, Dworetzky BA, White DP, Llewellyn N, Kothare SV (2013) Comparison of cardiorespiratory and EEG abnormalities with seizures in adults and children. Epilepsy Behav 29:537–541CrossRefPubMed
8.
go back to reference Moseley BD, Wirrell EC, Nickels K, Johnson JN, Ackerman MJ, Britton J (2011) Electrocardiographic and oximetric changes during partial complex and generalized seizures. Epilepsy Res 95:237–245CrossRefPubMed Moseley BD, Wirrell EC, Nickels K, Johnson JN, Ackerman MJ, Britton J (2011) Electrocardiographic and oximetric changes during partial complex and generalized seizures. Epilepsy Res 95:237–245CrossRefPubMed
9.
go back to reference Lotufo PA, Valiengo L, Bensenor IM, Brunoni AR (2012) A systematic review and meta-analysis of heart rate variability in epilepsy and antiepileptic drugs. Epilepsia 53:272–282CrossRefPubMed Lotufo PA, Valiengo L, Bensenor IM, Brunoni AR (2012) A systematic review and meta-analysis of heart rate variability in epilepsy and antiepileptic drugs. Epilepsia 53:272–282CrossRefPubMed
10.
go back to reference Umetani K, Singer DH, McCraty R, Atkinson M (1998) Twenty-four hour time domain heart rate variability and heart rate: relations to age and gender over nine decades. J Am Coll Cardiol 31:593–601CrossRefPubMed Umetani K, Singer DH, McCraty R, Atkinson M (1998) Twenty-four hour time domain heart rate variability and heart rate: relations to age and gender over nine decades. J Am Coll Cardiol 31:593–601CrossRefPubMed
11.
go back to reference Antelmi I, de Paula RS, Shinzato AR, Peres CA, Mansur AJ, Grupi CJ (2004) Influence of age, gender, body mass index, and functional capacity on heart rate variability in a cohort of subjects without heart disease. Am J Cardiol 93:381–385CrossRefPubMed Antelmi I, de Paula RS, Shinzato AR, Peres CA, Mansur AJ, Grupi CJ (2004) Influence of age, gender, body mass index, and functional capacity on heart rate variability in a cohort of subjects without heart disease. Am J Cardiol 93:381–385CrossRefPubMed
12.
go back to reference Fleming S, Thompson M, Stevens R, Heneghan C, Pluddemann A, Maconochie I, Tarassenko L, Mant D (2011) Normal ranges of heart rate and respiratory rate in children from birth to 18 years of age: a systematic review of observational studies. Lancet 377:1011–1018CrossRefPubMedPubMedCentral Fleming S, Thompson M, Stevens R, Heneghan C, Pluddemann A, Maconochie I, Tarassenko L, Mant D (2011) Normal ranges of heart rate and respiratory rate in children from birth to 18 years of age: a systematic review of observational studies. Lancet 377:1011–1018CrossRefPubMedPubMedCentral
13.
go back to reference Chen W, Guo CL, Zhang PS, Liu C, Qiao H, Zhang JG, Meng FG (2014) Heart rate changes in partial seizures: analysis of influencing factors among refractory patients. BMC Neurol 14:135CrossRefPubMedPubMedCentral Chen W, Guo CL, Zhang PS, Liu C, Qiao H, Zhang JG, Meng FG (2014) Heart rate changes in partial seizures: analysis of influencing factors among refractory patients. BMC Neurol 14:135CrossRefPubMedPubMedCentral
15.
go back to reference (1981) Proposal for revised clinical and electroencephalographic classification of epileptic seizures. From the Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia 22: 489–501 (1981) Proposal for revised clinical and electroencephalographic classification of epileptic seizures. From the Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia 22: 489–501
16.
go back to reference Isik U, Ayabakan C, Tokel K, Ozek MM (2012) Ictal electrocardiographic changes in children presenting with seizures. Pediatr Int 54:27–31CrossRefPubMed Isik U, Ayabakan C, Tokel K, Ozek MM (2012) Ictal electrocardiographic changes in children presenting with seizures. Pediatr Int 54:27–31CrossRefPubMed
17.
go back to reference Mayer H, Benninger F, Urak L, Plattner B, Geldner J, Feucht M (2004) EKG abnormalities in children and adolescents with symptomatic temporal lobe epilepsy. Neurology 63:324–328CrossRefPubMed Mayer H, Benninger F, Urak L, Plattner B, Geldner J, Feucht M (2004) EKG abnormalities in children and adolescents with symptomatic temporal lobe epilepsy. Neurology 63:324–328CrossRefPubMed
18.
go back to reference Raju KN, Choudhary N, Gulati S, Kabra M, Jaryal AK, Deepak KK, Pandey RM (2012) Comparison of heart rate variability among children with well controlled versus refractory epilepsy: a cross-sectional study. Epilepsy Res 101:88–91CrossRefPubMed Raju KN, Choudhary N, Gulati S, Kabra M, Jaryal AK, Deepak KK, Pandey RM (2012) Comparison of heart rate variability among children with well controlled versus refractory epilepsy: a cross-sectional study. Epilepsy Res 101:88–91CrossRefPubMed
19.
go back to reference Pagani M, Lombardi F, Guzzetti S, Rimoldi O, Furlan R, Pizzinelli P, Sandrone G, Malfatto G, Dell’Orto S, Piccaluga E, et al. (1986) Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. Circ Res 59:178–193CrossRefPubMed Pagani M, Lombardi F, Guzzetti S, Rimoldi O, Furlan R, Pizzinelli P, Sandrone G, Malfatto G, Dell’Orto S, Piccaluga E, et al. (1986) Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. Circ Res 59:178–193CrossRefPubMed
20.
go back to reference Cross JH, Jayakar P, Nordli D, Delalande O, Duchowny M, Wieser HG, Guerrini R, Mathern GW, International League against Epilepsy SfPES, Commissions of N, Paediatrics (2006) Proposed criteria for referral and evaluation of children for epilepsy surgery: recommendations of the Subcommission for Pediatric Epilepsy Surgery. Epilepsia 47:952–959CrossRef Cross JH, Jayakar P, Nordli D, Delalande O, Duchowny M, Wieser HG, Guerrini R, Mathern GW, International League against Epilepsy SfPES, Commissions of N, Paediatrics (2006) Proposed criteria for referral and evaluation of children for epilepsy surgery: recommendations of the Subcommission for Pediatric Epilepsy Surgery. Epilepsia 47:952–959CrossRef
22.
go back to reference Jansen K, Varon C, Van Huffel S, Lagae L (2013) Peri-ictal ECG changes in childhood epilepsy: implications for detection systems. Epilepsy Behav 29:72–76CrossRefPubMed Jansen K, Varon C, Van Huffel S, Lagae L (2013) Peri-ictal ECG changes in childhood epilepsy: implications for detection systems. Epilepsy Behav 29:72–76CrossRefPubMed
23.
go back to reference Ficker DM, So EL, Shen WK, Annegers JF, O’Brien PC, Cascino GD, Belau PG (1998) Population-based study of the incidence of sudden unexplained death in epilepsy. Neurology 51:1270–1274CrossRefPubMed Ficker DM, So EL, Shen WK, Annegers JF, O’Brien PC, Cascino GD, Belau PG (1998) Population-based study of the incidence of sudden unexplained death in epilepsy. Neurology 51:1270–1274CrossRefPubMed
24.
go back to reference Moseley B, Bateman L, Millichap JJ, Wirrell E, Panayiotopoulos CP (2013) Autonomic epileptic seizures, autonomic effects of seizures, and SUDEP. Epilepsy Behav 26:375–385CrossRefPubMed Moseley B, Bateman L, Millichap JJ, Wirrell E, Panayiotopoulos CP (2013) Autonomic epileptic seizures, autonomic effects of seizures, and SUDEP. Epilepsy Behav 26:375–385CrossRefPubMed
25.
go back to reference Evrengul H, Tanriverdi H, Dursunoglu D, Kaftan A, Kuru O, Unlu U, Kilic M (2005) Time and frequency domain analyses of heart rate variability in patients with epilepsy. Epilepsy Res 63:131–139CrossRefPubMed Evrengul H, Tanriverdi H, Dursunoglu D, Kaftan A, Kuru O, Unlu U, Kilic M (2005) Time and frequency domain analyses of heart rate variability in patients with epilepsy. Epilepsy Res 63:131–139CrossRefPubMed
26.
go back to reference Hilz MJ, Platsch G, Druschky K, Pauli E, Kuwert T, Stefan H, Neundorfer B, Druschky A (2003) Outcome of epilepsy surgery correlates with sympathetic modulation and neuroimaging of the heart. J Neurol Sci 216:153–162CrossRefPubMed Hilz MJ, Platsch G, Druschky K, Pauli E, Kuwert T, Stefan H, Neundorfer B, Druschky A (2003) Outcome of epilepsy surgery correlates with sympathetic modulation and neuroimaging of the heart. J Neurol Sci 216:153–162CrossRefPubMed
27.
go back to reference Persson H, Kumlien E, Ericson M, Tomson T (2005) Preoperative heart rate variability in relation to surgery outcome in refractory epilepsy. Neurology 65:1021–1025CrossRefPubMed Persson H, Kumlien E, Ericson M, Tomson T (2005) Preoperative heart rate variability in relation to surgery outcome in refractory epilepsy. Neurology 65:1021–1025CrossRefPubMed
28.
go back to reference Yang TF, Wong TT, Chang KP, Kwan SY, Kuo WY, Lee YC, Kuo TB (2001) Power spectrum analysis of heart rate variability in children with epilepsy. Childs Nerv Syst 17:602–606CrossRefPubMed Yang TF, Wong TT, Chang KP, Kwan SY, Kuo WY, Lee YC, Kuo TB (2001) Power spectrum analysis of heart rate variability in children with epilepsy. Childs Nerv Syst 17:602–606CrossRefPubMed
29.
go back to reference Osorio I, Schachter S (2011) Extracerebral detection of seizures: a new era in epileptology? Epilepsy Behav 22(Suppl 1):S82–S87CrossRefPubMed Osorio I, Schachter S (2011) Extracerebral detection of seizures: a new era in epileptology? Epilepsy Behav 22(Suppl 1):S82–S87CrossRefPubMed
Metadata
Title
Comparison of heart rate changes with ictal tachycardia seizures in adults and children
Authors
Wei Chen
Xi-Ting Zhang
Chang-Li Guo
Shu-Jing Zhang
Xian-Wei Zeng
Fan-Gang Meng
Publication date
01-04-2016
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 4/2016
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-016-3034-1

Other articles of this Issue 4/2016

Child's Nervous System 4/2016 Go to the issue