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Open Access 01-12-2011 | Research

Comparison of germinal center markers CD10, BCL6 and human germinal center-associated lymphoma (HGAL) in follicular lymphomas

Authors: Gaia Goteri, Guendalina Lucarini, Antonio Zizzi, Antonello Costagliola, Federica Giantomassi, Daniela Stramazzotti, Corrado Rubini, Pietro Leoni

Published in: Diagnostic Pathology | Issue 1/2011

Abstract

Background

Recently, human germinal center-associated lymphoma (HGAL) gene protein has been proposed as an adjunctive follicular marker to CD10 and BCL6.

Methods

Our aim was to evaluate immunoreactivity for HGAL in 82 cases of follicular lymphomas (FLs) - 67 nodal, 5 cutaneous and 10 transformed - which were all analysed histologically, by immunohistochemistry and PCR.

Results

Immunostaining for HGAL was more frequently positive (97.6%) than that for BCL6 (92.7%) and CD10 (90.2%) in FLs; the cases negative for bcl6 and/or for CD10 were all positive for HGAL, whereas the two cases negative for HGAL were positive with BCL6; no difference in HGAL immunostaining was found among different malignant subtypes or grades.

Conclusions

Therefore, HGAL can be used in the immunostaining of FLs as the most sensitive germinal center (GC)-marker; when applied alone, it would half the immunostaining costs, reserving the use of the other two markers only to HGAL-negative cases.

Virtual Slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1255638215567329.

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Title: Comparison of germinal center markers CD10, BCL6 and human germinal center-associated lymphoma (HGAL) in follicular lymphomas
Authors: Gaia Goteri
Guendalina Lucarini
Antonio Zizzi
Antonello Costagliola
Federica Giantomassi
Daniela Stramazzotti
Corrado Rubini
Pietro Leoni
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: Diagnostic Pathology / Issue 1/2011
Electronic ISSN: 1746-1596
DOI: https://doi.org/10.1186/1746-1596-6-97

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Comparison of germinal center markers CD10, BCL6 and human germinal center-associated lymphoma (HGAL) in follicular lymphomas

Abstract

Background

Methods

Results

Conclusions

Virtual Slides

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Virtual Slides

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