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Open Access 01-12-2015 | Research article

Comparison of cerebral blood flow in oral somatic delusion in patients with and without a history of depression: a comparative case series

Authors: Motoko Watanabe, Yojiro Umezaki, Anna Miura, Yukiko Shinohara, Tatsuya Yoshikawa, Tomomi Sakuma, Chisa Shitano, Ayano Katagiri, Miho Takenoshita, Akira Toriihara, Akihito Uezato, Toru Nishikawa, Haruhiko Motomura, Akira Toyofuku

Published in: BMC Psychiatry | Issue 1/2015

Abstract

Background

A significant number of patients visit dental clinics because of unusual oral sensations for which no physical cause can be found. Such patients are recognized as having oral somatic delusion (OSD). OSD may be either primary (monosymptomatic) or secondary to another disease, such as depression or cerebral infarction. Although the presenting complaints of patients with primary and secondary OSD are nearly indistinguishable, symptoms in patients with secondary OSD seem to be resistant to treatment compared with those in patients with primary OSD. Moreover, right dominant cerebral blood flow (CBF) has been reported in patients with primary OSD, but the difference in CBF between patients with primary and secondary OSD remains unclear. The aim of this study was to assess the differences in clinical characteristics and CBF distribution between patients with monosymptomatic OSD (non-depression group) and OSD in conjunction with remitted depression (depression group).

Methods

Participants were 27 patients of a psychosomatic dentistry clinic, all diagnosed with OSD. They were categorized into either the non-depression group (17 patients) or the depression group (10 patients) on the basis of assessments by their personal medical providers. CBF was examined using single-photon emission computed tomography.

Results

There was no difference in clinical presentation between the two groups. A significant right dominant asymmetry in the temporal and posterior cerebral regions was observed in both groups. In the central region, a right dominance was seen in the non-depression group, while a left dominance was seen in the depression group. Moreover, the mean regional CBF values for patients in the depression group were significantly lower in several regions (including bilateral callosomarginal, precentral, angular, temporal, posterior cerebral, pericallosal, lenticular nucleus, thalamus, and hippocampus; and right central and cerebellum) than for patients in the non-depression group.

Conclusion

These results suggest that the temporal and posterior cerebral regions are involved in in the pathophysiology of OSD, regardless of depression history, and that widespread CBF reduction is a characteristic of remitted depression.

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Title: Comparison of cerebral blood flow in oral somatic delusion in patients with and without a history of depression: a comparative case series
Authors: Motoko Watanabe
Yojiro Umezaki
Anna Miura
Yukiko Shinohara
Tatsuya Yoshikawa
Tomomi Sakuma
Chisa Shitano
Ayano Katagiri
Miho Takenoshita
Akira Toriihara
Akihito Uezato
Toru Nishikawa
Haruhiko Motomura
Akira Toyofuku
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: BMC Psychiatry / Issue 1/2015
Electronic ISSN: 1471-244X
DOI: https://doi.org/10.1186/s12888-015-0422-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Comparison of cerebral blood flow in oral somatic delusion in patients with and without a history of depression: a comparative case series

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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