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Archives of Gynecology and Obstetrics

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01-01-2010 | Original Article

Comparing GnRH agonist long protocol and gnrh antagonist protocol in outcome the first cycle of ART

Authors: Razieh Dehghani Firouzabadi, Shahnaz Ahmadi, Homa Oskouian, Robab Davar

Published in: Archives of Gynecology and Obstetrics | Issue 1/2010

Abstract

Purpose

This prospective study evaluated the efficacy of gonadotropin-releasing hormone (GnRH) antagonist protocol in comparison with the GnRH agonist protocol in the first cycle of assisted reproductive technique (ART).

Methods

We randomized 235 patients undergoing ART for the first time. The first group was stimulated with a standard long protocol and the second group stimulated with GnRH antagonis.

Results

There was no statistically significant difference in the age, infertility cause, basal FSH, BMI, the number of oocytes retrieved, number of M2 oocytes, embryo obtained and endometrial thickness between the two groups. But Serum estradiol, consumption of gonadotropins and ovarian hyperstimulation syndrome were significantly lower in the antagonist protocol. Cancellation rate of embryo transfer due to poor-quality embryo in the antagonist protocol was higher, but it was not significant. There was no significant difference in the clinical pregnancy and ongoing pregnancy between the two groups.

Conclusion

GnRH-antagonist is an effective, safe, and well-tolerated alternative to agonist in the first cycle of ART.

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Title: Comparing GnRH agonist long protocol and gnrh antagonist protocol in outcome the first cycle of ART
Authors: Razieh Dehghani Firouzabadi
Shahnaz Ahmadi
Homa Oskouian
Robab Davar
Publication date: 01-01-2010
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 1/2010
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-009-1073-5

2024 ASCO Annual Meeting

Springer Medicine

Comparing GnRH agonist long protocol and gnrh antagonist protocol in outcome the first cycle of ART

Abstract

Purpose

Methods

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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