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01-09-2015 | Original Article

Comparative study of hemodynamic changes caused by diazepam and midazolam during third molar surgery: a randomized controlled trial

Authors: Hécio Henrique Araújo de Morais, Jimmy Charles Melo Barbalho, Ricardo José de Holanda Vasconcellos, Fabricio Souza Landim, Fábio Andrey da Costa Araújo, Tasiana Guedes de Souza Dias

Published in: Oral and Maxillofacial Surgery | Issue 3/2015

Abstract

The aim of the present study was to compare hemodynamic changes using midazolam 7.5 mg and diazepam 10.0 mg during the surgical removal of symmetrically positioned third molars. A prospective, randomized, double-blind, clinical trial was carried out involving 120 patients divided into three groups: Group 1 (diazepam and placebo), Group 2 (midazolam and placebo), and Group 3 (diazepam and midazolam). Each subject underwent two surgeries on separate occasions under local anesthesia. The following parameters were assessed at five different times (T0, T1, T2, T3, and T4): systolic, diastolic, and mean blood pressure (SBP, DBP, and MBP, respectively); heart rate (HR); oxygen saturation (SpO₂); rate pressure product (RPP); and pressure rate quotient (PRQ). Statistically significant differences were found regarding heart rate at T2 and T3 (p < 0.005) in Group 2, with a higher rate occurring during midazolam administration. Moreover, significant differences in rate pressure product were found at T2, T3, and T4 in this group, with higher values also occurring during midazolam administration. In Group 3, significant differences in diastolic blood pressure were found at T3 and T4, with higher values occurring during diazepam administration, whereas a higher heart rate occurred at T3 with midazolam. Midazolam 7.5 mg and diazepam 10.0 mg exert an influence on some hemodynamic parameters without perceptible clinical changes in healthy patients undergoing lower third molar surgery.

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Title: Comparative study of hemodynamic changes caused by diazepam and midazolam during third molar surgery: a randomized controlled trial
Authors: Hécio Henrique Araújo de Morais
Jimmy Charles Melo Barbalho
Ricardo José de Holanda Vasconcellos
Fabricio Souza Landim
Fábio Andrey da Costa Araújo
Tasiana Guedes de Souza Dias
Publication date: 01-09-2015
Publisher: Springer Berlin Heidelberg
Published in: Oral and Maxillofacial Surgery / Issue 3/2015
Print ISSN: 1865-1550
Electronic ISSN: 1865-1569
DOI: https://doi.org/10.1007/s10006-015-0488-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Comparative study of hemodynamic changes caused by diazepam and midazolam during third molar surgery: a randomized controlled trial

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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