Skip to main content
Top
Published in: BMC Musculoskeletal Disorders 1/2008

Open Access 01-12-2008 | Research article

Comorbidity, limitations in activities and pain in patients with osteoarthritis of the hip or knee

Authors: Gabriella M van Dijk, Cindy Veenhof, Francois Schellevis, Harry Hulsmans, Jan PJ Bakker, Henk Arwert, Jos HM Dekker, Guus J Lankhorst, Joost Dekker

Published in: BMC Musculoskeletal Disorders | Issue 1/2008

Login to get access

Abstract

Background

This study aims to contribute to the knowledge of the influence of comorbidity in OA. The objectives of the study were (i) to describe the prevalence of comorbidity and (ii) to describe the relationship between comorbidity (morbidity count, severity and the presence of specific diseases) and limitations in activities and pain in elderly patients with knee or hip OA using a comprehensive inventory of comorbidity.

Methods

A cross-sectional cohort study was conducted, in which 288 elderly patients with hip or knee osteoarthritis were included. Apart from demographic and clinical data, information about comorbidity, limitations in activities (WOMAC, SF-36 and timed walking test) and pain (VAS) was collected by questionnaires and tests. Statistical analyses included descriptive statistics, multivariate regression techniques, t-tests and one-way ANOVA.

Results

Almost all patients suffered from at least one comorbid disease, with cardiac diseases, diseases of eye, ear, nose, throat and larynx, other urogenital diseases and endocrine/metabolic diseases being most prevalent. Morbidity count and severity index were associated with more limitations in activities and with more pain. The presence of most of the moderate or severe diseases and obesity was associated with limitations in activities or with pain.

Conclusion

The results of this study emphasize the importance of comorbidity in the rehabilitation of elderly patients with osteoarthritis of the hip or knee. Clinical practitioners should be aware of the relationship of comorbidity with functional problems in OA patients.
Appendix
Available only for authorised users
Literature
1.
go back to reference Kadam UT, Jordan K, Croft PR: Clinical comorbidity in patients with osteoarthritis: a case-control study of general practice consulters in England and Wales. Ann Rheum Dis. 2004, 63 (4): 408-414. 10.1136/ard.2003.007526.CrossRefPubMedPubMedCentral Kadam UT, Jordan K, Croft PR: Clinical comorbidity in patients with osteoarthritis: a case-control study of general practice consulters in England and Wales. Ann Rheum Dis. 2004, 63 (4): 408-414. 10.1136/ard.2003.007526.CrossRefPubMedPubMedCentral
2.
go back to reference Akker van den M, Buntinx F, Roos S, Knottnerus JA: Problems in determining occurence rates in multimorbidity. J Clin Epidemiol. 2001, 54: 675-679. 10.1016/S0895-4356(00)00358-9.CrossRefPubMed Akker van den M, Buntinx F, Roos S, Knottnerus JA: Problems in determining occurence rates in multimorbidity. J Clin Epidemiol. 2001, 54: 675-679. 10.1016/S0895-4356(00)00358-9.CrossRefPubMed
3.
go back to reference Caporali R, Cimmino MA, Sarzi-Puttini P, Scarpa R, Parazzini F, Zaninelli A: Comorbid conditions in the AMICA study patients: effects on the quality of life and drug prescriptions by general practitioners and specialists. Semin Arthritis Rheum. 2005, 35 (1 Suppl 1): 31-37. 10.1016/j.semarthrit.2005.02.004.CrossRefPubMed Caporali R, Cimmino MA, Sarzi-Puttini P, Scarpa R, Parazzini F, Zaninelli A: Comorbid conditions in the AMICA study patients: effects on the quality of life and drug prescriptions by general practitioners and specialists. Semin Arthritis Rheum. 2005, 35 (1 Suppl 1): 31-37. 10.1016/j.semarthrit.2005.02.004.CrossRefPubMed
4.
go back to reference Gabriel SE, Crowson CS, O'Fallon WM: Comorbidity in arthritis. J Rheumatol. 1999, 26 (11): 2475-2479.PubMed Gabriel SE, Crowson CS, O'Fallon WM: Comorbidity in arthritis. J Rheumatol. 1999, 26 (11): 2475-2479.PubMed
5.
go back to reference Marks R, Allegrante JP: Comorbid disease profiles of adults with end-stage hip osteoarthritis. Med Sci Monit. 2002, 8 (4): CR305-CR309.PubMed Marks R, Allegrante JP: Comorbid disease profiles of adults with end-stage hip osteoarthritis. Med Sci Monit. 2002, 8 (4): CR305-CR309.PubMed
6.
go back to reference Schellevis FG, van d V, van de LE, van Eijk JT, van Weel C: Comorbidity of chronic diseases in general practice. J Clin Epidemiol. 1993, 46 (5): 469-473. 10.1016/0895-4356(93)90024-U.CrossRefPubMed Schellevis FG, van d V, van de LE, van Eijk JT, van Weel C: Comorbidity of chronic diseases in general practice. J Clin Epidemiol. 1993, 46 (5): 469-473. 10.1016/0895-4356(93)90024-U.CrossRefPubMed
7.
go back to reference Stang PE, Brandenburg NA, Lane MC, Merikangas KR, Von Korff MR, Kessler RC: Mental and physical comorbid conditions and days in role among persons with arthritis. Psychosom Med. 2006, 68 (1): 152-158. 10.1097/01.psy.0000195821.25811.b4.CrossRefPubMedPubMedCentral Stang PE, Brandenburg NA, Lane MC, Merikangas KR, Von Korff MR, Kessler RC: Mental and physical comorbid conditions and days in role among persons with arthritis. Psychosom Med. 2006, 68 (1): 152-158. 10.1097/01.psy.0000195821.25811.b4.CrossRefPubMedPubMedCentral
8.
go back to reference Cimmino MA, Sarzi-Puttini P, Scarpa R, Caporali R, Parazzini F, Zaninelli A: Clinical presentation of osteoarthritis in general practice: determinants of pain in Italian patients in the AMICA study. Semin Arthritis Rheum. 2005, 35 (1 Suppl 1): 17-23. 10.1016/j.semarthrit.2005.01.015.CrossRefPubMed Cimmino MA, Sarzi-Puttini P, Scarpa R, Caporali R, Parazzini F, Zaninelli A: Clinical presentation of osteoarthritis in general practice: determinants of pain in Italian patients in the AMICA study. Semin Arthritis Rheum. 2005, 35 (1 Suppl 1): 17-23. 10.1016/j.semarthrit.2005.01.015.CrossRefPubMed
9.
go back to reference Gijsen R, Hoeymans N, Schellevis FG, Ruwaard D, Satariano WA, Bos van den GAM: Causes and consequences of comorbidity: A review. J Clin Epidemiol. 2001, 54: 661-674. 10.1016/S0895-4356(00)00363-2.CrossRefPubMed Gijsen R, Hoeymans N, Schellevis FG, Ruwaard D, Satariano WA, Bos van den GAM: Causes and consequences of comorbidity: A review. J Clin Epidemiol. 2001, 54: 661-674. 10.1016/S0895-4356(00)00363-2.CrossRefPubMed
10.
go back to reference Rigler SK, Studenski S, Wallace D, Rejer DM, Duncan PW: Co-morbidity adjustment for functional outcomes in community-dwelling older adults. Clin Rehab. 2002, 16: 420-428. 10.1191/0269215502cr515oa.CrossRef Rigler SK, Studenski S, Wallace D, Rejer DM, Duncan PW: Co-morbidity adjustment for functional outcomes in community-dwelling older adults. Clin Rehab. 2002, 16: 420-428. 10.1191/0269215502cr515oa.CrossRef
11.
go back to reference Verbrugge LM, Gates DM, Ike RW: Risk factors for disability among U.S. adults with arthritis. J Clin Epidemiol. 1991, 44 (2): 167-182. 10.1016/0895-4356(91)90264-A.CrossRefPubMed Verbrugge LM, Gates DM, Ike RW: Risk factors for disability among U.S. adults with arthritis. J Clin Epidemiol. 1991, 44 (2): 167-182. 10.1016/0895-4356(91)90264-A.CrossRefPubMed
12.
go back to reference Heijmans M, Rijken P, Schellevis F, Bos van den G: Meer dan een ziekte; De gevolgen van comorbiditeit vanuit het perspectief van chronisch zieken en gehandicapten. 2003, Amsterdam/Utrecht: Twin Design bv Heijmans M, Rijken P, Schellevis F, Bos van den G: Meer dan een ziekte; De gevolgen van comorbiditeit vanuit het perspectief van chronisch zieken en gehandicapten. 2003, Amsterdam/Utrecht: Twin Design bv
13.
go back to reference Fortin M, Dubois MF, Hudon C, Soubhi H, Almirall J: Multimorbidity and quality of life: a closer look. Health Qual Life Outcomes. 2007, 5: 52-10.1186/1477-7525-5-52.CrossRefPubMedPubMedCentral Fortin M, Dubois MF, Hudon C, Soubhi H, Almirall J: Multimorbidity and quality of life: a closer look. Health Qual Life Outcomes. 2007, 5: 52-10.1186/1477-7525-5-52.CrossRefPubMedPubMedCentral
14.
go back to reference Tuominen U, Blom M, Hirvonen J, Seitsalo S, Lehto M, Paavolainen P: The effect of co-morbidities on health-related quality of life in patients placed on the waiting list for total joint replacement. Health Qual Life Outcomes. 2007, 5: 16-10.1186/1477-7525-5-16.CrossRefPubMedPubMedCentral Tuominen U, Blom M, Hirvonen J, Seitsalo S, Lehto M, Paavolainen P: The effect of co-morbidities on health-related quality of life in patients placed on the waiting list for total joint replacement. Health Qual Life Outcomes. 2007, 5: 16-10.1186/1477-7525-5-16.CrossRefPubMedPubMedCentral
15.
go back to reference Ettinger WH, Davis MA, Neuhaus JM, Mallon KP: Long-term physical functioning in persons with knee osteoarthritis from NHANES. I: Effects of comorbid medical conditions. J Clin Epidemiol. 1994, 47 (7): 809-815. 10.1016/0895-4356(94)90178-3.CrossRefPubMed Ettinger WH, Davis MA, Neuhaus JM, Mallon KP: Long-term physical functioning in persons with knee osteoarthritis from NHANES. I: Effects of comorbid medical conditions. J Clin Epidemiol. 1994, 47 (7): 809-815. 10.1016/0895-4356(94)90178-3.CrossRefPubMed
16.
go back to reference Weigl M, Angst F, Aeschlimann A, Lehmann S, Stucki G: Predictors for response to rehabilitation in patients with hip or knee osteoarthritis: a comparison of logistic regression models with three different definitions of responder. Osteoarthritis Cartilage. 2006, 14 (7): 641-651. 10.1016/j.joca.2006.01.001.CrossRefPubMed Weigl M, Angst F, Aeschlimann A, Lehmann S, Stucki G: Predictors for response to rehabilitation in patients with hip or knee osteoarthritis: a comparison of logistic regression models with three different definitions of responder. Osteoarthritis Cartilage. 2006, 14 (7): 641-651. 10.1016/j.joca.2006.01.001.CrossRefPubMed
17.
go back to reference Creamer M: Factors associated with functional impairment in symptomatic knee OA. Rheumatology. 2000, 39 (5): 490-496. 10.1093/rheumatology/39.5.490.CrossRefPubMed Creamer M: Factors associated with functional impairment in symptomatic knee OA. Rheumatology. 2000, 39 (5): 490-496. 10.1093/rheumatology/39.5.490.CrossRefPubMed
18.
go back to reference Rosemann T, Grol R, Hermann K, Wensing M, Szecsenyi J: Association between obesity, quality of life, physical activity and health service utilization in primary care patients with osteoarthritis. Int J Behav Nutr Phys Act. 2008, 5 (1): 4-10.1186/1479-5868-5-4.CrossRefPubMedPubMedCentral Rosemann T, Grol R, Hermann K, Wensing M, Szecsenyi J: Association between obesity, quality of life, physical activity and health service utilization in primary care patients with osteoarthritis. Int J Behav Nutr Phys Act. 2008, 5 (1): 4-10.1186/1479-5868-5-4.CrossRefPubMedPubMedCentral
19.
go back to reference Rijken M, van Kerkhof M, Dekker J, Schellevis FG: Comorbidity of chronic diseases; Effects of disease pairs on physical and mental functioning. Qual Life Res. 2005, 14: 45-55. 10.1007/s11136-004-0616-2.CrossRefPubMed Rijken M, van Kerkhof M, Dekker J, Schellevis FG: Comorbidity of chronic diseases; Effects of disease pairs on physical and mental functioning. Qual Life Res. 2005, 14: 45-55. 10.1007/s11136-004-0616-2.CrossRefPubMed
20.
go back to reference Linn BS, Linn MW, Gurel L: Cumulative Illness Rating Scale. J Am Geriatr Soc. 1968, 16 (5): 622-626.CrossRefPubMed Linn BS, Linn MW, Gurel L: Cumulative Illness Rating Scale. J Am Geriatr Soc. 1968, 16 (5): 622-626.CrossRefPubMed
21.
go back to reference Lequesne M, Mery C, Samson M, Gerard D: Indices of severity for osteoarthritis of the hip and knee. Scand J Rheumatol. 1987, 18 (Suppl 65): 85-89. 10.3109/03009748709102182.CrossRef Lequesne M, Mery C, Samson M, Gerard D: Indices of severity for osteoarthritis of the hip and knee. Scand J Rheumatol. 1987, 18 (Suppl 65): 85-89. 10.3109/03009748709102182.CrossRef
22.
go back to reference Altman R, Hochberg M, Murphy W, Wolfe F, Lequesne M: Atlas of individual radiopgraphic features in osteoarthritis. Osteoarthritis Cartilage. 1995, 3 (Suppl A): 3-70.PubMed Altman R, Hochberg M, Murphy W, Wolfe F, Lequesne M: Atlas of individual radiopgraphic features in osteoarthritis. Osteoarthritis Cartilage. 1995, 3 (Suppl A): 3-70.PubMed
23.
go back to reference Dieppe P: Recommended methodology for assessing the progression of osteoarthritis of the hip and knee joints. Osteoarthritis Cartilage. 1995, 3 (2): 73-7. 10.1016/S1063-4584(05)80040-8.CrossRefPubMed Dieppe P: Recommended methodology for assessing the progression of osteoarthritis of the hip and knee joints. Osteoarthritis Cartilage. 1995, 3 (2): 73-7. 10.1016/S1063-4584(05)80040-8.CrossRefPubMed
24.
go back to reference Aaronson N, Muller M, Cohen P, Essink-Bot ML, Fekkes M, Sanderman R: Translation, validation, and norming of the Dutch language version of the SF-36 Health Survey in community and chronic diseases. J Clin Epidemiol. 1998, 51 (11): 1055-1068. 10.1016/S0895-4356(98)00097-3.CrossRefPubMed Aaronson N, Muller M, Cohen P, Essink-Bot ML, Fekkes M, Sanderman R: Translation, validation, and norming of the Dutch language version of the SF-36 Health Survey in community and chronic diseases. J Clin Epidemiol. 1998, 51 (11): 1055-1068. 10.1016/S0895-4356(98)00097-3.CrossRefPubMed
25.
go back to reference McHorney C, Ware J, Raczek A: The MOS 36-item Short Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental constructs. Medical Care. 1993, 31 (3): 247-263. 10.1097/00005650-199303000-00006.CrossRefPubMed McHorney C, Ware J, Raczek A: The MOS 36-item Short Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental constructs. Medical Care. 1993, 31 (3): 247-263. 10.1097/00005650-199303000-00006.CrossRefPubMed
26.
go back to reference Wade D, Wood V, Heller A, Maggs J, Hewer R: Walking after stroke. Scand J Rehab Med. 1987, 19: 25-30. Wade D, Wood V, Heller A, Maggs J, Hewer R: Walking after stroke. Scand J Rehab Med. 1987, 19: 25-30.
27.
go back to reference Bellamy N, Buchanan W, Gldsmith C, Campbell J, Stitt L: Validation study of WOMAC: a health status instrument for measuring clinically-important patient-relevant outcomes following total hip or knee arthroplasty in osteoarthritis. J Orth Rheumatol. 1988, 1: 95-108. Bellamy N, Buchanan W, Gldsmith C, Campbell J, Stitt L: Validation study of WOMAC: a health status instrument for measuring clinically-important patient-relevant outcomes following total hip or knee arthroplasty in osteoarthritis. J Orth Rheumatol. 1988, 1: 95-108.
28.
go back to reference Roorda LD, Jones CA, Waltz M, Lankhorst GJ, Bouter LM, Eijken van der JW: Satisfactory cross cultural equivalence of the Dutch WOMAC in patients with hip osteoarthritis waiting for arthroplasty. Ann Rheum Dis. 2004, 63 (1): 36-42. 10.1136/ard.2002.001784.CrossRefPubMedPubMedCentral Roorda LD, Jones CA, Waltz M, Lankhorst GJ, Bouter LM, Eijken van der JW: Satisfactory cross cultural equivalence of the Dutch WOMAC in patients with hip osteoarthritis waiting for arthroplasty. Ann Rheum Dis. 2004, 63 (1): 36-42. 10.1136/ard.2002.001784.CrossRefPubMedPubMedCentral
29.
go back to reference Conwell Y, Forbes N, Cox C, Caine E: Validation of a measure of physical Ilness Burden at autopsy: the Cumulative Illness Rating Scale. J Am Geriatr Soc. 1993, 41 (1): 38-41.CrossRefPubMed Conwell Y, Forbes N, Cox C, Caine E: Validation of a measure of physical Ilness Burden at autopsy: the Cumulative Illness Rating Scale. J Am Geriatr Soc. 1993, 41 (1): 38-41.CrossRefPubMed
30.
go back to reference Fortin M, Hudon C, Dubois M, Almirall J, Lapointe L, Soubhi H: Comparative assessment of three different indices of multimorbidity for studies on health-related quality of life. Health Qual Life Outcomes. 2005, 3 (74): Fortin M, Hudon C, Dubois M, Almirall J, Lapointe L, Soubhi H: Comparative assessment of three different indices of multimorbidity for studies on health-related quality of life. Health Qual Life Outcomes. 2005, 3 (74):
31.
go back to reference Veenhof C, Bijlsma JWJ, Ende van den CHM, van Dijk GM, Pisters MF, Dekker J: Psychometric evaluation of osteoarthritis questionnaires: a systematic review of the literature. Arthritis Care Res. 2005, Veenhof C, Bijlsma JWJ, Ende van den CHM, van Dijk GM, Pisters MF, Dekker J: Psychometric evaluation of osteoarthritis questionnaires: a systematic review of the literature. Arthritis Care Res. 2005,
32.
go back to reference Zee van der K, Sanderman R: Het meten van de algemene gezondheidstoestand met de RAND-36; een handleiding. Noordelijk Centrum voor Gezondheidsvraagstukken, Rijksuniversiteit Groningen. 1993 Zee van der K, Sanderman R: Het meten van de algemene gezondheidstoestand met de RAND-36; een handleiding. Noordelijk Centrum voor Gezondheidsvraagstukken, Rijksuniversiteit Groningen. 1993
33.
go back to reference Peters TJ, Sanders C, Dieppe P, Donovan J: Factors associated with change in pain and disability over time: a community-based prospective observational study of hip and knee osteoarthritis. Br J Gen Pract. 2005, 55 (512): 205-211.PubMedPubMedCentral Peters TJ, Sanders C, Dieppe P, Donovan J: Factors associated with change in pain and disability over time: a community-based prospective observational study of hip and knee osteoarthritis. Br J Gen Pract. 2005, 55 (512): 205-211.PubMedPubMedCentral
34.
go back to reference van Dijk GM, Dekker J, Veenhof C, Ende van den CHM: The course of functional status and pain in osteoarthritis of hip or knee: a systematic review. 2005, van Dijk GM, Dekker J, Veenhof C, Ende van den CHM: The course of functional status and pain in osteoarthritis of hip or knee: a systematic review. 2005,
35.
go back to reference Eaton C: Obesity as a risk factor for osteoarthritis: mecahnical versus metabolic. Med Health RI. 2004, 87 (7): 201-204. Eaton C: Obesity as a risk factor for osteoarthritis: mecahnical versus metabolic. Med Health RI. 2004, 87 (7): 201-204.
36.
go back to reference Messier S, Loeser RF, Miller JD, Morgan J, Rejeski W, Sevich M: Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet and Activity Promotion Trial. Arthr Rheum. 2006, 50 (5): 1501-1510. 10.1002/art.20256.CrossRef Messier S, Loeser RF, Miller JD, Morgan J, Rejeski W, Sevich M: Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet and Activity Promotion Trial. Arthr Rheum. 2006, 50 (5): 1501-1510. 10.1002/art.20256.CrossRef
37.
go back to reference Dekker J, Boot B, Woude van der L, Bijlsma J: Pain and disability in osteoarthritis: a review of behavioral mechanisms. Journal of behavoral medicine. 1992, 15 (2): 189-214. 10.1007/BF00848325.CrossRef Dekker J, Boot B, Woude van der L, Bijlsma J: Pain and disability in osteoarthritis: a review of behavioral mechanisms. Journal of behavoral medicine. 1992, 15 (2): 189-214. 10.1007/BF00848325.CrossRef
38.
go back to reference Katz JN, Chang LC, Sangha O, Fossel AH, Bates DW: Can comorbidity be measured by questionnaires rather than medical record review?. Med Care. 1996, 34 (1): 73-84. 10.1097/00005650-199601000-00006.CrossRefPubMed Katz JN, Chang LC, Sangha O, Fossel AH, Bates DW: Can comorbidity be measured by questionnaires rather than medical record review?. Med Care. 1996, 34 (1): 73-84. 10.1097/00005650-199601000-00006.CrossRefPubMed
Metadata
Title
Comorbidity, limitations in activities and pain in patients with osteoarthritis of the hip or knee
Authors
Gabriella M van Dijk
Cindy Veenhof
Francois Schellevis
Harry Hulsmans
Jan PJ Bakker
Henk Arwert
Jos HM Dekker
Guus J Lankhorst
Joost Dekker
Publication date
01-12-2008
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2008
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/1471-2474-9-95

Other articles of this Issue 1/2008

BMC Musculoskeletal Disorders 1/2008 Go to the issue