Published in:
Open Access
01-12-2016 | Letter
Common genetic susceptibility to DCIS and invasive ductal carcinoma
Authors:
Victoria Sopik, Steven A. Narod
Published in:
Breast Cancer Research
|
Issue 1/2016
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Excerpt
In a recent issue of
Breast Cancer Research, Petridis and colleagues report a failure to detect any genetic polymorphism which predisposes to ductal carcinoma in situ (DCIS) but not to invasive ductal carcinoma (IDC) or vice versa [
1]. They genotyped 5067 cases of DCIS, 24,584 cases of IDC, and 37,467 non-cancer controls for 76 different single nucleotide polymorphisms (SNPs), each of which has been shown to be associated with breast cancer susceptibility in previous studies [
2,
3]. They found no significant difference in the magnitude of the associations for DCIS and IDC for any of the 76 loci. From this, the authors conclude that the genes responsible for DCIS and IDC are, by and large, the same and that larger studies are required to determine if susceptibility loci specific to DCIS exist. …