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Open Access 01-07-2009 | Comment
Commentary on the WHO 2008 classification of neoplasms arising from histiocytic and other accessory cells
Published in: Journal of Hematopathology | Issue 2/2009
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Histiocytes and dendritic cells belong to a group of immunoregulatory cells that are responsible for antigen processing and presentation to lymphocytes. Neoplasms of histiocytic and dendritic origin are very rare [1], making up less than 1% of tumours in lymph nodes. Thus, information regarding epidemiology, prognosis and treatment [2, 3] is scarce. Table 1 summatizes the neoplasms derived from histiocytes and other accessory cells according to the 2001 and 2008 WHO classification.
Table 1
A summary of the neoplasms derived from histiocytes and other accessory cells in the 2001 and 2008 WHO classification
|
2001 WHO classification
|
2008 WHO classification
|
Comments
|
|---|---|---|
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Histiocytic sarcoma
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Histiocytic sarcoma
|
No change
|
|
Langerhans cell histiocytosis Langerhans cell sarcoma
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Tumours derived from Langerhans cells (Langerhans cell histiocytosis, Langerhans cell sarcoma)
|
No change
|
|
Interdigitating dendritic cell sarcoma/tumour
|
Interdigitating dendritic cell sarcoma
|
Use sarcoma terminology
|
|
Follicular dendritic cell sarcoma/tumour
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Follicular dendritic cell sarcoma
|
Use sarcoma terminology
|
|
Dendritic cell sarcoma, NOS
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Other rare dendritic cell tumours including indeterminate dendritic cell tumour, fibroblastic reticular
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Addition of 2 other tumours of dendritic origin to recognise myeloid and stroma-derived dendritic cells
|
|
Disseminated juvenile xanthogranuloma
|
New entity
|