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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2017

01-12-2017 | Colorectal Cancer

Comment on: Need for Differentiating Diabetes-Specific Mortality from Total Mortality when Comparing Metformin with Insulin Regarding Cancer Survival

Authors: Tina Fransgaard, MD, Lau Caspar Thygesen, PhD, Ismail Gögenur, MD, DMSc

Published in: Annals of Surgical Oncology | Special Issue 3/2017

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Excerpt

In our study,1 the association between metformin and all-cause mortality in patients undergoing surgery for colorectal cancer was examined. The overall survival was increased in the metformin-treated group compared with the insulin group. Here we address the issue of whether it remains unclear whether the findings are due to the antitumor role of metformin or lower prevalence of severe diabetes complications, and whether there is a need to differentiate diabetes-specific mortality from total mortality. …
Literature
1.
Fransgaard T, Thygesen LC, Gögenur I. Metformin increases overall survival in patients with diabetes undergoing surgery for colorectal cancer. Ann. Surg. Oncol. 2016;23(5):1569–75.CrossRefPubMed
2.
Dehal AN, Newton CC, Jacobs EJ, Patel AV, Gapstur SM, Campbell PT. Impact of diabetes mellitus and insulin use on survival after colorectal cancer diagnosis: the Cancer Prevention Study-II Nutrition Cohort. J. Clin. Oncol. 2012;30(1):53–9.CrossRefPubMed
3.
4.
Metadata
Title
Comment on: Need for Differentiating Diabetes-Specific Mortality from Total Mortality when Comparing Metformin with Insulin Regarding Cancer Survival
Authors
Tina Fransgaard, MD
Lau Caspar Thygesen, PhD
Ismail Gögenur, MD, DMSc
Publication date
01-12-2017
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue Special Issue 3/2017
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-017-6177-8

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