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European Journal of Nutrition
Published in: European Journal of Nutrition 8/2009

01-12-2009 | Letter to the Editor

Comment on “Effects of adipocyte-secreted factors on cell cycle progression in HT29 cells” published by Eur J Nutr

Authors: Jiezhong Chen, Xu-Feng Huang

Published in: European Journal of Nutrition | Issue 8/2009

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Excerpt

Obesity is associated with one-third of colon cancer. This is related to altered adipocyte-secreted factors including increased leptin and decreased adiponectin levels [3]. These risk factors cause increased signal pathways important in the carcinogenesis of colon cancer. We read with great interest the paper “Effects of adipocyte-secreted factors on cell cycle progression in HT29 cells” published in your journal [8]. The author screened 30 conditional adipocyte media on HT29 cell growth. In 11 of these, positive responses were found. Furthermore, the author also demonstrated that leptin upregulates ERK pathway, which was inhibited by genistein [6, 7]. …
Literature
1.
Banerjee S, Li Y, Wang Z, Sarkar FH (2008) Multi-targeted therapy of cancer by genistein. Cancer Lett 269:226–242CrossRef
2.
Chen J (2008) Is Src the key to understanding metastasis and developing new treatments for colon cancer? Nat Clin Pract Gastroenterol Hepatol 5:306–307CrossRef
3.
Chen J, Huang XF (2009) Obesity, the PI3K/Akt signal pathway and colon cancer. Obes Rev. 12 Jun 2009. [Epub ahead of print]
4.
Chen J, McMillan NAJ (2008) Molecular basis of pathogenesis, prognosis and therapy in chronic lymphocytic leukaemia. Cancer Biol Ther 7:174–179
5.
Jaffe T, Schwartz B (2008) Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways. Int J Cancer 123:2543–2556CrossRef
6.
Li Y, Sarkar FH (2002) Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathway. Clin Cancer Res 8:2369–2377
7.
Park SS, Kim YN, Jeon YK, Kim YA, Kim JE, Kim H, Kim CW (2005) Genistein-induced apoptosis via Akt signaling pathway in anaplastic large-cell lymphoma. Cancer Chemother Pharmacol 56:271–278CrossRef
8.
Schnäbele K, Roser S, Rechkemmer G, Hauner H, Skurk T (2009) Effects of adipocyte-secreted factors on cell cycle progression in HT29 cells. Eur J Nutr 48:154–161 (Epub ahead)CrossRef
Metadata
Title
Comment on “Effects of adipocyte-secreted factors on cell cycle progression in HT29 cells” published by Eur J Nutr
Authors
Jiezhong Chen
Xu-Feng Huang
Publication date
01-12-2009
Publisher
D. Steinkopff-Verlag
Published in
European Journal of Nutrition / Issue 8/2009
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-009-0040-z

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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