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Thrombosis Journal
Published in: Thrombosis Journal 1/2018

Open Access 01-12-2018 | Case report

Combined life-threatening thromboses and hemorrhages in a patient with afibrinogenemia and antithrombin deficiency

Authors: S. Le Quellec, A. Desjonqueres, L. Rugeri, H. Desmurs Clavel, F. Farhat, L. Mechtouff, Y. Dargaud

Published in: Thrombosis Journal | Issue 1/2018

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Abstract

Background

Patients with congenital afibrinogenemia suffer from spontaneous recurrent severe bleeding. While fibrinogen concentrates are known to effectively treat bleeding episodes, thrombotic complications often occur upon replacement therapy, rendering clinical management highly challenging.

Case Presentation

We hereby report a case of combined afibrinogenemia and congenital antithrombin deficiency manifested by recurrent life-threatening bleeding, as well as spontaneous severe arterial occlusion, such as acute coronary syndrome and stroke, and venous thromboses like pulmonary embolism.
Secondary fibrinogen prophylaxis is recommended following any initial life-threatening bleeding episode in patients with afibrinogenemia, yet the high associated risk of thrombosis illustrates the complexity of choosing the most effective prophylaxis strategy combining fibrinogen concentrate with antithrombotic agent for optimal protection against the risk of both severe bleeding and thrombosis. For our patient, the thrombin generation assay objectively confirmed her prothrombotic tendency.

Conclusion

This case may help us better understand the pathophysiology of arterial thrombosis in afibrinogenemia, while highlighting the difficulty of managing such complications.
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Metadata
Title
Combined life-threatening thromboses and hemorrhages in a patient with afibrinogenemia and antithrombin deficiency
Authors
S. Le Quellec
A. Desjonqueres
L. Rugeri
H. Desmurs Clavel
F. Farhat
L. Mechtouff
Y. Dargaud
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Thrombosis Journal / Issue 1/2018
Electronic ISSN: 1477-9560
DOI
https://doi.org/10.1186/s12959-018-0162-8

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